1995 -1999，北京师范大学，学士

　　1999 -2002，中国科学院上海药物研究所，硕士

　　2002 -2008，美国Brandeis大学，博士

　　2008 -2009，美国Brandeis大学，博士后

　　2009 -2012，美国哈佛医学院，博士后

　　2012-2014，中科院上海生科院生化与细胞所，蛋白质中心(筹)，核磁应用主管

　　2014年起任中科院上海生科院生化与细胞所研究员

　　本课题组主要是以核磁共振(NMR)方法为主，结合其它分子生物学手段来研究膜蛋白的结构、功能与分子机制。目前课题组的主要研究内容有：

　　1. 解析线粒体中关键膜蛋白及其复合物的三维结构，并基于结构进行功能分析，提出并验证这些蛋白质发挥生理功能或引发代谢疾病的分子机制。

　　2. 免疫应答中跨膜信号转导的机制，以及肿瘤微环境对免疫受体分子和配体分子功能影响的分子基础。

1. Wen, M. #*; Cao, Y.#; Wu, B.#; Xiao, T.; Cao, R.; Wang, Q.; Liu, X.; Xue, H.; Yu, Y.; Lin, J.; Xu, C.; Xu, J. and OuYang, B.* PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain. Nature Communications 2021, 12, 1-13.
2. Zhang, N.#; Tang, M.#; Wen, M.; Cao, Y.*; OuYang, B.* Expression, purification and characterization of tmco1 for structural studies. Protein expression and purification 2021, 179, 105803.
3. Wei, S.#; Hu, X.#; Du, L.; Zhao, L.; Xue, H.; Liu, C.; Chou, J.J.; Zhong, J.; Tong, Y.*; Wang, S.* and OuYang, B.* Inhibitor development against p7 channel in hepatitis c virus. Molecules 2021, 26.
4. Lv, F.#; Qi, F.#; Zhang, Z.#; Wen, M.#; Kale, J.#; Piai, A.; Du, L.; Wang, S.; Zhou, L.; Yang, Y.; Wu, B.; Liu, Z.; Rosario, J.; Pogmore, J.; Chou, J. J.; Andrews, D. W.*; Lin, J.*; and OuYang, B.*. An amphipathic bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. The EMBO journal 2021, e106438.
5. Li, R.#; Zhang, N.#; Wu, B.; OuYang, B.*; Shen, H*. Multiobjective heuristic algorithm for de novo protein design in a quantified continuous sequence space. Comput Struct Biotechnol J. 2021, 19, 2575-2587.
6. Yuan, Y.#; Cao, C.#; Wen, M.#; Li, M.; Dong, Y.; Wu, L.; Wu, J.; Cui, T.; Li, D.; Chou, J.J.* and OuYang, B.*. Structural characterization of the n-terminal domain of the dictyostelium discoideum mitochondrial calcium uniporter. ACS omega 2020, 5, 6452-6460.
7. Zhao, L.; Wang, S.; Zhu, Q.; Wu, B.; Liu, Z.; OuYang, B.*; Chou, J.J*. Specific interaction of the human mitochondrial uncoupling protein 1 with free long-chain fatty acid. Structure 2017, 25, 1371-1379 e1373.
8. Zhao, L.; Wang, S.; Run, C.; OuYang, B.*; Chou, J.J.* Specific lipid binding of membrane proteins in detergent micelles characterized by nmr and molecular dynamics. Biochemistry 2016, 55, 5317-5320.
9. Zhao, L.; Wang, S.; Du, L.; Dev, J.; Zhou, L.; Liu, Z.; Chou, J.J.*; OuYang, B.* Structural basis of interaction between the hepatitis c virus p7 channel and its blocker hexamethylene amiloride. Protein & cell 2016, 7, 300-304.
10. Run, C.; Yang, Q.; Liu, Z.; OuYang, B.*; Chou, J.J.* Molecular basis of mgatp selectivity of the mitochondrial scamc carrier. Structure 2015, 23, 1394-1403.
11. OuYang, B.; Chou, J.J.* The minimalist architectures of viroporins and their therapeutic implications. Biochimica et biophysica acta 2014, 1838, 1058-1067.
12. OuYang, B.; Xie, S.; Berardi, M.J.; Zhao, X.; Dev, J.; Yu, W.; Sun, B.; Chou, J.J.* Unusual architecture of the p7 channel from hepatitis c virus. Nature 2013, 498, 521-525.
13. OuYang, B.; Pochapsky, S.S.; Dang, M.; Pochapsky, T.C.* A functional proline switch in cytochrome p450cam. Structure 2008, 16, 916-923.
14. OuYang, B.; Pochapsky, S.S.; Pagani, G.M.; Pochapsky, T.C.* Specific effects of potassium ion binding on wild-type and l358p cytochrome p450cam. Biochemistry 2006, 45, 14379-14388.
15. OuYang, B.; Ke, C.; He, Z.; Yang, Y.*; Ye, Y.* Brazilide a, a novel lactone with an unprecedented skeleton from caesalpinia sappan. Tetrahedron Letters 2002, 43, 1731-1733.