1998年获美国冷泉港实验室和纽约州立大学石溪分校分子生物学和生物化学博士学位，1999到2005于美国加州大学洛杉机分校医学院从事癌症研究，先后为博士后和助理教授，2006年应聘中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员。

　　组蛋白甲基化是重要的表观遗传修饰，可发生在赖氨酸或是精氨酸修饰位点上，而且每个修饰位点可以有不同的甲基化修饰状态。根据修饰位点以及修饰状态的不同，组蛋白甲基化修饰可以激活或抑制基因转录，从而参与正常生理过程以及疾病的发生和发展。

　　我实验室主要研究组蛋白去甲基化酶(去除组蛋白甲基化的酶)，目前的研究集中于：

　　1. 结合生物信息学，用高通量筛选方法寻找新的组蛋白去甲基化酶

　　2. 用敲除小鼠模型研究组蛋白去甲基化酶的生物学功能

1. Cao X, Chen Y, Wu B, Wang X, Xue H, Yu L, Li J, Wang Y, Wang W, Xu Q, Mao H, Peng C, Han G, Chen CD. Histone H4K20 Demethylation by Two hHR23 Proteins. Cell Rep. 2020 Mar 24;30(12):4152-4164
2. Zheng L, Xu L, Xu Q, Yu L, Zhao D, Chen P, Wang W, Wang Y, Han G, Chen CD. Utx loss causes myeloid transformation. Leukemia. 2018 Jun;32(6):1458-1465.
3. Chen X, Wang S, Zhou Y, Han Y, Li S, Xu Q, Xu L, Zhu Z, Deng Y, Yu L, Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W, Chen CD. Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nat Commun. 2018 Jan 9;9(1):114
4. Zhang F, Xu L, Xu L, Xu Q, Karsenty G, Chen CD. Histone demethylase JMJD3 is required for osteoblast differentiation in mice. Sci Rep. 2015 Aug 25;5:13418
5. Mao H, Han G, Xu L, Zhu D, Lin H, Cao X, Yu Y, Chen CD. Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram. Stem Cell Res Ther. 2015 Jul 21;6(1):132.
6. Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD, Shi Y, Zhang X. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol. 2015 7(6):505-16
7. Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 2015 7(1) 23-34
8. Han G, Li J, Wang Y, Li X, Mao H, Liu Y, Chen CD. The Hydroxylation Activity of Jmjd6 Is Required for Its Homo-oligomerization, Journal of Cellular Biochemistry. 2012 113:1663-1670.
9. Lin H, Wang Y, Wang Y, Tian F, Pu P, Yu Y, Mao H, Yang Y, Wang P, Hu L, Lin Y, Liu Y, Xu Y, and Chen CD. Coordinated regulation of active and repressive histone methylations by a dual specificity histone demethylase ceKDM7A from C. elegans. Cell Research, 2010 20(8):899-907.
10. Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, and Xu Y. Structural insights into a dual specificity histone demethylase ceKDM7A from C. elegans Cell Research, 2010 20(8):886-98.
11. Zhu Z, Wang Y, Li X, Wang Y, Xu L, Wang X, Sun T, Mao H, Yu Y, Li J, Chen PA, and Chen CD. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Research, 2010 20(7):794-801.
12. Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K, Jing N, Chen CD. Dual specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Research, 2010 20(2):154-65.
13. Xiang Y, Zhu Z, Han G, Ye X, Xu B, Peng Z, Ma Y, Yu Y, Lin H, Chen AP, Chen CD. JARID1B is a histone H3 lysine 4 demethylase upregulated in prostate cancer. PNAS. 2007 104 (49):19226-19231.
14. Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD. JMJD3 is a histone H3 lysine 27 demethylase. Cell Research, 2007 17(10):850-857.

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