首页 全所PI名录
  • 陈正军
  • 研究员,研究组长,博士生导师
  • E-mail: zjchen@@sibcb.ac.cn
  • 实验室主页: 
    个人简介:
  •   1983毕业于第二军医大学军医系(临床医学),留校任教,1988年获得国家教委青年奖学金赴德国留学;1989-1993在德国乌尔姆大学医学院攻读医学博士,获得医学博士学位,继后在乌尔姆大学血液肿瘤研究所任博士后;1994年起在德国马普科学院生化所博士后、高级研究人员和课题负责人;2000年获得”百人计划”引进人才,受聘于中科院上海生物化学与细胞生物学研究所,任研究员,博士生导师。现任中科院分子细胞科学卓越创新中心研究员,课题组长,2012年起任上海科技大学生命技术学院特聘教授。

      曾担任上海第二军医大学国际合作生物信号传递研究中心客座教授,兼副主任,并获得过一项解放军科技进步一等奖和两项解放军科技进步三等奖,获得上海市优秀学科带头人称号,国务院特殊津贴获得者。曾担任上海生科院生物化学与细胞生物学研究所所长助理,国家分子生物学重点实验室副主任,中科院蛋白质组学重点实验室副主任,中科院上海临床中心癌症研究中心主任,中国蛋白质组学学会常务委员,上海生物工程学学会理事, 上海生命科学联盟首轮会长。

      现任上海细胞生物学学会理事长,中国细胞生物学学常务会理事,中国细胞学会细胞结构和细胞行为专业分会会长,长三角助力创新联盟(“一市三省”科协共同签署)常务理事。科技部重大科学研究计划(973)项目首席科学家主持,自然科学基金重点和重大项目首席主持,负责多项国家级和中国科学院科的研究项目,上海市优秀学科带头人计划等项目的研究工作。

    社会任职:
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    研究方向:
  • 磷酸化蛋白质细胞信号网络与肿瘤发生
    研究工作:
  •   磷酸化蛋白信号通路和细胞极性信号在细胞命运,细胞行为和肿瘤(肝癌)发生发展调控作用和机制

      主要关注受体型酪氨酸磷酸化蛋白质激酶及其跨膜信号调控蛋白质复合物和细胞极性信号与细胞命运,迁移、增殖和肿瘤发生的相关性研究:(1) 生长因子受体(HER家族, FGFRs,VEGFR)及其跨膜蛋白复合物(SIRPs,SHP1/2, Csk-Cpb, SFKs,)介导信号调控网路生物学功能和肿瘤中作用的研究;(2)细胞极性蛋白复合物Par-复合物(Par3/Par6/aPKC/Cdc42/Lgl)和紧密连接蛋白复合物(Occludin)细胞极性的功能和非细胞极性功能研究;(3) Par复合物在细胞命运决定,迁移,增殖及肿瘤发生发展功能和机制研究。

    承担科研项目情况:
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    代表论著:
    1. Zhang Z.#, Li W.#, Yang G., Lu X, Qi X., Wang S., CaoC., Zhang P., Ren J., Zhao J., Zhang J., Hong S., Tan Y., Burchfield J., Yu Y., Xu T., Yao X., James D., Feng W.* and Chen Z* CASK modulates the assembly and function of Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov. Accepted.
    2. Wei Z, Lei J, Shen F, Dai Y, SunY, Liu Y, Dai Y, Jian Z, Wang S, Chen Z*, Liao K*, Hong S*. Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells. Advanced Science, 202000963 2020, (https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202000963)
    3. Li JT,Yin M,Wang D,Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG,Wang YP,Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma Nat Cell Biol. 2020 Feb;22(2): 167-174.
    4. Zhang, L., Lu, Y., Wang, Y., Wang, F., Zhai, S., Chen, Z., Cai, Z. (2020) PHF14 is required for germinal center B cell development. Cell Immunol. 358:104221. doi: 10.1016/j.cellimm.2020.104221. Epub 2020 Sep 28
    5. Zhang Q, Pan Y, Zeng B, Zheng X, Wang H, Shen X, Li H, Jiang Q, Zhao J, Meng Z, Li P, Chen Z, Wei H, Liu Z*. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells. Cell Res. 2019 Jul;29(7):516-532
    6. Zhang L,Wei N,Cui Y,Hong Z, Liu X,Wang Q,Li S,Liu H,Yu H,Cai Y,Wang Q, Zhu J, Meng W, Chen Z*, Wang C*. The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway. PLoS Pathog. 2018 Nov 2;14(11):
    7. He B, Yang X, Li Y, Huang D, Xu X, Yang W, Dai Y, Zhang H, Chen Z*, Cheng W*. TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia. Hypertension. 2018 Apr;71(4):671-680.
    8. Zhang L, Huang Q, Lou J, Zou L, Wang Y, Zhang P, Yang G, Zhang J, Yu L, Yan D, Zhang C, Qiao J, Wang S, Wang S, Xu Y, Ji H, Chen Z*, Zhang Z*. A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis. Oncotarget. 2017 Mar 21;8(12):19684-19698.
    9. Yang B, Chen S, Wu M, Zhang L, Ruan M, Chen X, Chen Z* Mei C*, Mao Z*. PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. Sci Rep. 2017 Jan 3;7:39888. doi: 10.1038/srep39888.
    10. Zheng, C., Wang, Y., Yang, L., Zhou, S., Gao, Y., Li, F., Feng, Y., Wang, Z., Zhan, L., Yan, Q., Zhu, X., Wong, K. K., Chen, Z. *, Ji, H*. (2017)  Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis Sci Rep. 4;7(1):10407. doi: 10.1038/s41598-017- 10891-0
    11. Zhang P, Wang S, Qiao J , Zhang L , Zhang Z , Chen Z* (2016)  Dual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation. Cell Discov.2:16021. doi: 10.1038/celldisc.
    12. Huang Q, Zhang L, Wang Y, Zhang C, Zhou S, Yang G, Li Z, Gao X, Chen Z*, and Zhang Z* (2013). Depletion of PHF14, coding for a novel histone-binding protein, caused neonatal lethality in mice due to respiratory failure. Acta Biochimica et Biophysica Sinica. 45(8):622-33,.
    13. Zhang, K., Zhao, H., Ji, Z., Zhang, C., Zhou, P., Wang, L., Chen, Q., Wang, J., Zhang, P., Chen, Z., Zhu, H. H., Gao, W. Q (2011)  Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition Oncogene. 35(10):1271-82.
    14. Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z* (2010).. The tight junction protein, Occludin, regulates the directional migration of epithelial cells. Developmental Cell. 18(1):52-63,
    15. Yuan H, Zhang H, Wu X, Zhang Z, Du D, Zhou S, Brakebusch C, and Chen Z*. (2009) Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 49:240-9.
    16. Lu X, Feng X, Man X, Yang G, Tang L, Du D, Zhang F, Yuan H, Huang Q, Zhang Z, Liu Y, Strand D, and Chen Z*. (2009)  Aberrant splicing of Hugl-1, the human homologue of Drosophila tumor suppressor gene lgl, is associated with hepatocellular carcinoma progression. Clin Cancer Res. 15 (10):3287-96.
    17. Feng X, Lu X, Man X, Zhou W, Jiang LQ, Knyazev P, Lei L, Huang Q, Ullrich A, Zhang Z*, and Chen Z*(2009). Overexpression of Csk binding protein (Cbp) contributes to renal cell carcinogenesis. Oncogene 28 (37):3320-31,
    18. Yang G, Li Q, Ren S, Lu X, Fang L, Zhou W, Zhang F, Xu F, Zhang Z, Zeng R, Lottspeich F, and Chen Z* (2009). Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins. Proteomics. 9(21):4944-61,.
    19. Zhou W, Feng X, Wu Y, Benge J, Zhang Z, and Chen Z* (2009)  FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. Cell Research. 19(10): 1165-77
    20. Du, D., Pedersen, E., Wang, Z., Karlsson, R., Chen, Z., Wu, X., Brakebusch, C. (2009)  Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1 Exp Cell Res. 315(8):1480-9. doi: 10.1016/j.yexcr.2008.11.012. Epub 2008 Dec 3.
    21. Ren, S., Yang, G., He, Y., Wang, Y., Li, Y., Chen, Z*. (2008) The conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains BMC Genomics. 9:452. doi: 10.1186/1471-2164-9-452.
    22. Wang YG, Du D, Fang LH, Yang G, Zhang CY, Lottspeich F, Ullrich A and Chen ZJ*. (2006) Tyrosine Phosphorylated Par3 Regulates Epithelial Tight Junction Assembly Promoted by EGFR Signaling. EMBO J., 5: 5058-5070.
    23. Fang LH, Wang YG, Du D, Yang G, Kwok T, Kong S, Chen B, Chen D and Chen ZJ*. (2007). Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Cell Res. 17: 100-116.(Highlighted by Cell and Nature Cell Biology)
    24. Wang YG, Li RX, Du D, Zhang CY, Yuan HX, Zeng R* and Chen ZJ*. (2006) Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway. J Proteome. Res., 5: 846-855. (Featured Article in J Proteome. Res;Highlighted by J Proteome. Res 2006)
    25. Jiang QF, Feng XJ, Zhou WC, Knyazev P, Ullrich A and Chen Z*. (2006) Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. Oncogene, 25: 5495-5506.
    26. Yuan HX, Zhang L, Liu AH, Zhou H, Wang YG, Zhang H, Wang GQ, Zeng R, Zhang YL* and Chen ZJ*. (2006) Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J. Proteome.Res, 5:299-307.
    27. Zong XG, Eckert C, Yuan HX, Wahl-Schott C, Abicht H, Fang LH, Li RX, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen ZJ *and Biel M*. (2005) Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase. J. Biol. Chem., 280(40): 34224–34232.
    28. Wu Y, Chen ZJ, Ullrich A*. (2003) EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol.Chem.,384(8):1215-26.
    29. Wu, C. J., Chen, Z., Ullrich, A., Greene, M. I., O'Rourke, D. M. (2000) Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs) Oncogene 19(35):3999-4010. doi: 10.1038/sj.onc.1203748 .
    30. Seiffert, M., Cant, C., Chen, Z., Rappold, I., Brugger, W., Kanz, L., Brown, E. J., Ullrich, A., Buhring, H. J. (1999)  Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood 1;94(11):3633-43.
    31. Kharitonenkov A#, Chen ZJ#, Sures I, Wang H and Ullrich A. (1997)  A Family of Proteins that Inhibit Signaling through Tyrosine Kinase Receptors. Nature, 386: 181-186. (# co-first authors)
    获奖及荣誉:
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    研究组成员:
  • 合影