1991-1995年吉林大学分子生物学系，学士;1995-1998年吉林大学酶工程国家重点实验室，硕士;1998-2001年中国科学院遗传与发育生物学研究所，博士;2001-2008年，美国德克萨斯大学西南医学中心，先后为博士后、助理讲师;2009年经中国科学院引进回国，受聘于中科院生化与细胞所，任研究员，研究组长。2015年兼任上海科技大学特聘教授，现任中科院分子细胞科学卓越创新中心特聘研究员。2009年获上海市“浦江人才计划”资助，2016年获“国家杰出青年基金”支持。

        组织器官发育的大小最终取决于其组成细胞的数目、细胞大小及细胞间精确而复杂的排列组合，相关调控机制的异常将直接导致癌症等重大疾病的发生。Hippo信号通路是一条物种间高度保守的肿瘤抑制信号通路，是迄今被确认在调控器官发育大小、再生与重塑过程中起主导作用的信号通路。它不仅能通过调节细胞生长、增殖及凋亡来控制组织、器官的生长，还在组织稳态维持与干细胞的自我更新、分化等生命活动过程中发挥着极其重要的作用。已有研究表明，Hippo信号通路的突变或失衡可以导致包括癌症在内的多种疾病的发生。因此，阐明Hippo信号通路在器官大小调控及组织稳态维持中的作用将具有十分重要的理论与现实意义。    
        本实验室主要利用遗传学、生物化学、分子与细胞生物学等研究手段，同时结合果蝇遗传模型与小鼠疾病模型，旨在从分子、细胞和动物水平解析Hippo等信号网络在调控细胞增殖、干细胞稳态与肿瘤发生中的功能及分子机制。我们的最终目标是揭示器官发育的大小调控机制与组织稳态维持机理，并在此基础上为癌症等疾病的诊断和治疗提供可行的方法和策略。

1. Lingli He^# , Liang Yuan^#, Yang Sun, Wentao Yu, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hangzi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang,* & Lei Zhang*  A regulation loop between YAP and NR4A1 balances cell proliferation and apoptosis.  Cell Reports 2020, 33(3): 108284
2. Jinlong Suo^#,Xue Feng^#,Jiayi Li,Jinghui Wang,Zuoyun Wang1*,Lei Zhang*, Weiguo Zou* VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances 2020, 6(43)::eaba4147
3. Xue Feng, Tiantian Lu, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Margaret S. Ho, Yun Zhao, Shuqun Cheng*, Wei Tian* and Lei Zhang* The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice. Hepatology, 2020, 71(6):1988-2004
4. Xue Hao, Shimin Wang, Yi Lu, Wentao Yu, Pengyue Li, Dan Jiang, Tong Guo, Mengjie Li, Jinhui Li, Jinjin Xu, Wenqing Wu, Margaret S. Ho*, Lei Zhang*  Lola regulates Drosophila adult midgut homeostasis via non-canonical Hippo signaling. eLife, 2020, 9:e47542
5. Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang* and Hai Jiang*  SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling. Protein & Cell, 2020,epub
6. Jiang Gao, Lingli He, Lulu Zhou, Yingying Jing, Feng Wang, Yan Shi, Mingjun Cai, Jiayin Sun, Haijiao Xu, Junguang Jiang, Lei Zhang, Hongda Wang  Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging. Nanoscale, 2020, 12(4):2703-2714
7. Cheng Yan, Jingqi Liu, Jiamei Gao, Ying Sun, Lei Zhang, Haiyun    Song, Lei Xue, Lixing Zhan, Guanjun Gao, Zunji Ke and Yong Liu*,Jingnan Liu*  IRE1 Promotes Neurodegeneration through Autophagy-dependent Neuron Death in the Drosophila Model of Parkinson’s Disease  Cell Death and Disease, 2019, 10:800
8. Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang,Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu* and Lei Zhang* Dual function of VGLL4 in muscle regeneration. EMBO Journal, 2019,38(17): e101051
9. Lingli He, Liang Yuan, Yang Sun, Pingyang Wang, Hailin Zhang, Xue Feng,Zuoyun Wang, Wenxiang Zhang, Chuanyu Yang, Yi Arial Zeng, Yun Zhao, Ceshi Chen* & Lei Zhang* Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression. Cancer Research, 2019, 79(17):4399-4411
10. Wei Yu, Xueyan Ma, Jinjin Xu, Andreas Wilhelm Heumüller, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang*, Bin Zhou* and Lei Zhang*  VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genetics, 2019, (15) 2:e1007977
11. Mengjie Li, Xiaolong Hu, Shu Zhang, Margaret S. Ho, Geng Wu*, Lei Zhang*  Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila. Scientific Reports, 2019,9(1):10124
12. Weiping Li, Liguang Yang, Qiang He, Chaobo Hu, Linying Zhu, Xiaolong Ma, Xueyan Ma, Shujie Bao, Lu Li, Yingying Chen, Xing Deng, Xin Zhang, Jin Cen, Lei Zhang, Zhong Wang, Wei-Fen Xie, Hong Li, Yixue Li,and Lijian Hui  A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling. Cell Stem Cell, 2019, 25:54-68
13. Wantae Kim,Yongsuk Cho, Xiaohui Wang, Ogyi Park, Xueyan Ma, Hanjun Kim, Wenjian Gan, Eek-Hoon Jho, Boksik Cha, Yun-ji Jeung, Lei Zhang, Bin Gao, Wenyi Wei, Jin Jiang, Kyung-sook Chung, Yingzi Yang, Hippo Signaling Is Intrinsically Regulated during Cell Cycle Progression by APC/C^Cdh1. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(19):9423-9432
14. Huiyi Wang, Qiaoyun Long, Shanbo Tang, Qiong Xiao, Chuan Gao, Quanyi Zhao, Qinglan Li, Mei Ye, Lei Zhang, Lianyun Li, Min Wu  Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. Nucleic Acids Research,  2019 47(5):2349-2364 
15. Lin-Gao Ju, Yuan Zhu, Qiao-Yun Long, Xue-Jing Li, Xiang Lin, Shan-Bo Tang , Lei Yin, Yu Xiao, Xing-Huan Wang, Lianyun Li, Lei Zhang, Min Wu   SPOP Suppresses Prostate Cancer through Regulation of CYCLIN E1 Stability. Cell Death and Differentiation, 2019, 26(6):1156-1168
16. Wenxiang Zhang, Jinjin Xu, Jinhui Li, Tong Guo, Dan Jiang, Xue Feng, Xueyan Ma, Lingli He, Wenqing Wu, Mengxin Yin, Ling Ge, Zuoyun Wang, Margaret S. Ho, Yun Zhao, Zhaoliang Fei* and Lei Zhang*  The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting cofactors VGLL4 and CtBP2 into a transcriptional complex. The Journal of Biological Chemistry, 2018, 293(44): 17119-17134
17. Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi* and Lei Zhang*  Staurosporine targets the Hippo pathway to inhibit cell growth. Journal of Molecular Cell Biology , 2018, 10(3): 267-269
18. Jiajun Xu, Xue Hao, Meng-Xin Yin, Yi Lu, Yunyun Jin, Jinjin Xu, Ling Ge, Wenqing Wu, Margaret Ho, Yingzi Yang, Yun Zhao, Lei Zhang*  Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development, 2017, 144:1510-1517
19. Jing Gao, Lingli He, Yan Shi, Mingjun Cai, Haijiao Xu Junguang Jiang Lei Zhang*, and Hongda Wang*  Cell Contact and Pressure Control of YAP Localization and Clustering Revealed by Super-resolution Imaging. Nanoscale, 2017, 9(43):16993-17003
20. Chiao-Ming Lin, Jiajun Xu, Wen-Ting Yang, Chao Wang, Yu-Chiao Li, Lien-Chieh Cheng, Lei Zhang*, and Jui-Chou Hsu*  Smurf downregulates Echinoid in the amnioserosa to regulate Drosophila dorsal closure. Genetics, 2017, 206: 985-992
21. Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Hao Chen, Jialin Fan, Wenqing Wu, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao  UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO Reports, 2017,18(11):1922-1934.
22. Hsinyi Huang, Wenjing Zhang, Yafang Pan, Yijun Gao, Lei Deng, Fuming Li, Fei Li, Xueyan Ma, Shenda Hou, Jing Xu, Peixue li, Xiaoxun Li, Guohong Hu, Cheng Li, Haiquan Chen, Lei Zhang, and Hongbin Ji  YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Research, 2017, 77(21): 5769-5781
23. Shuo Zhang, Chenyu Pan, Xiangdong Lv, Wei Wu, Hao Chen, Wenqing Wu, Hailong Wu, Lei Zhang, Yun Zhao  Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis. Scientific Reports, 2017, 7:5101
24. Shi Jiao, Chuanchuan Li, Qian Hao, Haofei Miao, Lei Zhang, Lin Li, Zhaocai Zhou  VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nature communications, 2017, 8:14058
25. Shimin Wang, Yi Lu, Meng-Xin Yin, Chao Wang, Wei Wu, Jinhui Li, Wenqing Wu, Ling Ge, Lianxin Hu, Yun Zhao, Lei Zhang* Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal. The Journal of Biological Chemistry, 2016,291(15):7926-37
26. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, and Yun Zhao Lei Zhang* Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery, 2016,2,16006
27. Lianxin Hu, Jiajun Xu, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xu, Margaret S. Ho, Guanjun Gao, Yun Zhao, Lei Zhang*  Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Cell Discovery, 2016, 2, 15047
28. Peng Zhang, Shuting Wang, Sai Wang, Jing Qiao, Lei zhang, Zhe Zhang Zhengjun Chen  Dual Function of Partitioning-defective 3 in the Regulation of YAP Phosphorylation and Activation. Cell Discovery, 2016,2, 16021
29. Lin Fu, Hailong Wu, Steven Y. Cheng, Daming Gao, Lei Zhang, Yun Zhao Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammal. eLife, 2016, 5:e15690
30. Xiangdong Lv, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Zhaocai Zhou, Lei zhang, Zhijun Han, Gang Wei, Min Wu, Lin LI, Yun Zhao A Positive Role for Polycomb in Transcriptional Regulation via H4K20me1. Cell Research, 2016, 26:529-542
31. Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang,Tong Guo, Hui Han, Haiyun Song, Lei Zhang, and Yun Zhao  SUMO Regulates Somatic Cyst Stem Cells Maintenance and Directly TargetsHedgehog Pathway in Adult Drosophila Testis. Development, 2016, 143(10):1655-62
32. Jing Xu, Pei-xue Li, Jun Wu, Yi-jun Gao, Meng-xin Yin, Ye Lin, Ming Yang, Dong-ping Chen, Hai-peng Sun, Zeng-bo Liu, Xiang-chen Gu, Hong-ling Huang, Li-li Fu, Hui-min Hu, Liang-liang He, Wen-qing Wu, Zhao-liang Fei, Hong-bin Ji, Lei Zhang*, Chang-Lin Mei* Involvement of the Hippo Pathway in Regeneration and Fibrogenesis after Ischemic Acute Kidney Injury: YAP is the Key Effector. Clinical Science, 2016,130:349-363
33. Hui Han, Jialin Fan, Yue Xiong, Yi Lu, Wenqing Wu, Lei Zhang, and Yun Zhao Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription. Scientific Reports, 2016，6：18937
34. Fangfang Jiang, Falong Lu, Peixue Li, Wei Liu, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang, and Yong Q. Zhang Drosophila homolog of FMRP maintains genome integrity by interacting with Piwi. Journal of Genetics and Genomics, 2016, 43:11-24
35. Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao, Lei Zhang*  Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications, 2015, 6:6607
36. Liang Dong, Jinhui Li, Hongling Huang, Meng-Xin Yin, Jinjin Xu, Peixue Li, Yi Lu, Wenqing Wu, Hang Yang, Yun Zhao, Lei Zhang* Growth Suppressor Lingerer Regulates bantam microRNA to Restrict Organ Size. Journal of Molecular Cell Biology, 2015 7(5):415-428
37. Mengxin Yin and Lei Zhang*  Hippo signaling in epithelial stem cells. Acta Biochimica et Biophysica Sinica, 2015, 47(1):39-45 (invited review)
38. Lei Zhang*  Control of growth and beyond: a special issue on Hippo signaling. Acta Biochimica et Biophysica Sinica, 2015, 47(1):1 (Editorial)
39. Wenjing Zhang, Yijun Gao, Fuming Li, Xinyuan Tong ,Yan Ren, Xiangkun Han, Shun Yao, Fei Long, Zhongzhou Yang, Hengyu Fan, Lei Zhang, Hongbin Ji  YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of Survivin. Cancer Research, 2015,75(21):4450-7
40. Shuying Shen, Xiaocan Guo, Huan Yan, Yi Lu, Xinyan Ji, Li Li, Tingbo Liang, Dawang Zhou, Xin-Hua Feng, Jonathan Zhao, Jindan Yu, Xing-Guo Gong, Lei zhang，Bin Zhao  A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Research, 2015,25(9):997-1012
41. Chunying Liu, Yue Xiong, Jing Feng, Lei Zhang, Yun Zhao  Sqh is involved in the regulation of Ci stability in Hh signaling pathway. Journal of Molecular Cell Biology, 2015, 7(6),584-587
42. Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu,Wenqing Wu, Junhai Han, Zhaocai Zhou, Hai Jiang, Lei Zhang, Yun Zhao  Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discovery, 2015, 1:15006
43. Ye Zhu, Dong Li, Yadong Wang, Chunli Pei, Song Liu, Lei Zhang, Zengqiang Yuan, Peng Zhang  Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs. Cellular Signalling, 2015, 27: 606-613
44. Lianxin Hu, Hongling Huang, Jinhui Li, Meng-Xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang* Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control. The Journal of Biological Chemistry, 2014, 289:33598-33607
45. Yijun Gao, Wenjing Zhang, Xiangkun Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun, Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan Chen, Lei Zhang* & Hongbin Ji*  YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nature Communications, 2014, 5:4629
46. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji*, Lei Zhang*, Zhaocai Zhou*. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell, 2014, 25: 166-180
47. Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao*, Lei Zhang*  Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo. Developmental Biology, 2014, 385:211-219
48. Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, XiangKun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Fuming Li, Haiquan Chen, Zhaocai Zhou*, Lei Zhang* and Hongbin Ji*  VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEADs transcriptional complex. Cell Research, 2014, 24: 331-343
49. Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang, Yun Zhao  Kto-Skd complex can regulate ptc expression by interacting with Ci in Hedgehog signaling pathway. The Journal of Biological Chemistry, 2014 289 (32): 22333-41
50. Xiangkun Han, Fuming Li, Zhaoyuan Fang, Yijun Gao, Fei Li, Rong Fang, Shun Yao, Yihua Sun, Li Li, Wenjing Zhang, Huimin Ma, Qian Xiao, Gaoxiang Ge, Jing Fang, Hongda Wang, Lei Zhang, Kwok-kin Wong, Haiquan Chen, Yingyong Hou, Hongbin Ji. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nature Communications, 2014, 5:3261
51. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S. Ho, Hongbin Ji, Yun Zhao*, Lei Zhang*  Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling. eLife, 2013 2: e00999
52. Hongling Huang, Shimin Wang, Mengxin Yin,Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao*, Xin-Yuan Liu* and Lei Zhang*  Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association. PLoS Biology, 2013,11(4) e1001620 (Press released by PLoS Biology)
53. Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao*, Lei Zhang*  A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research, 2013，23:1201-1214
54. Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou,Feng Liu, Lei Zhang* and Yun Zhao*   Atrophin/Rpd3 complex represses Hedgehog signaling by interacting with Ci. The Journal of Cell Biology, 2013, 203:575-583
55. Zhao Zhang,  Xiangdong Lv,  Wen-chi Yin,  Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang* and Yun Zhao*  Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation. Developmental Cell, 2013, 25: 636-644
56. Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang*, and Yun Zhao*. Drosophila Vps36 is involved in Hh signaling by regulating Smo trafficking. Journal of Cell Science, 2013，126:4230-4238
57. Hongling Huang, Wenqing Wu, Lei Zhang* and Xin-Yuan Liu* Drosophila Ste-20 family protein kinase, Hippo, modulates Fat cell proliferation. PLoS One, 2013, 8: e61740
58. Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang*, and Yun Zhao* Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts is Essential for High Hh Activity Transduction. The Journal of Biological Chemistry, 2013,  288(18): 12605-12614
59. Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang* and Zhaocai Zhou*. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure, 2013, 21:680-688
60. Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang*, Yun Zhao*. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Research, 2013 23(4): 573-576
61. Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao, and Zhaocai Zhou. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism. Structure, 2013, 21: 449-461
62. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai zhou, Jin Jiang, Yun Zhao*  and Lei Zhang*. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. The Journal of Biological Chemistry, 2012, 287: 5784-5796
63. Mengxin Yin and Lei Zhang*. Hippo signaling, a hub of growth control, tumor suppression and pluripotency maintenance. Journal of Genetics and Genomics, 2011, 38: 471-481 (invited review)
64. Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang* and Yun Zhao*. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Research, 2011, 21: 1436-1451
65. Fangfang Ren, Lei Zhang, Jin Jiang. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Developmental Biology, 2010, 337, 303-312
66. Lei Zhang, Tao Yue and Jin Jiang. Hippo signaling pathway and organ size control. Fly, 2009, 3(1), 1-6 (invited review).
67. Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, and Jin Jiang. The TEAD/TEF family of transcription factor Scalloped mediates nuclear responses to the Hippo pathway in organ size control. Developmental Cell, 2008，14：377-387
68. Lei Zhang, Jianhang Jia, Bing Wang, Kazuhito Amanai, Keith A. Wharton Jr, Jin Jiang. Regulation of wingless signaling by the CKI family in Drosophila limb development. Developmental Biology, 2006, 299: 221-237
69. Qing Zhang^#, Lei Zhang^#, Bing Wang, Chan-Yen Oh, Cheng-Ting Chien, ang Jin Jiang. A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor. Developmental Cell, 2006, 10：719-729 (* Equally contributed to this work)
70. Jianhang Jia^#, Lei Zhang^#, Qing Zhang^# Chao Tong, Bing Wang, Fajian Hou, Kazuhito Amanai and Jin Jiang. Phosphorylation by Double-time/CKIε and CKIα targets Cubitus interruptus for Slimb/β-TRCP mediated proteolytic processing. Developmental cell, 2005, 9: 819-830  (* Equally contributed to this work)
71. Zhipan Yang, Lei zhang, Fengqiu Diao, Meijuan Huang, Naihu Wu Sucrose regulates elongation of Carrot somatic embryo radicles as a signal molecule. Plant Molecular Biology, 2004，54：441-459
72. HuiXin.Lin, Lei Zhang, Zhipan Yang, Meijuan Huang, Naihu Wu^* Molecular Characterization of Poly(A)-binding Protein from Daucus carota. DNA sequencing, 2004, 14(2): 147-153
73. Yiming Liu, Fengqiu Diao, Lei Zhang, Meijuan Huang, Naihu Wu^*  Cloning and function analysis of DcLEA1 , a new number of LEA gene family. Progress in Natural Science, 14(5) 20-26 (2004)
74.  Huixin Lin, Lei Zhang, Zhipan Yang, Meijuan Huang, Naihu Wu^*  Isolation and Functional Identification of DcPAB from Daucus carota. Chinese Journal of Biochemistry and Molecular biology, 2004, 20 (3)319-324 (in Chinese, English abstract)
75.  Zhipan Yang, lei Zhang, Fengqiu, Meijuan Huang, Naihu Wu^* 　Cloning and expression of DnaJ homolog in Carrot somatic embryo. Progress in Natural Science, 2003,13(5) 350-356
76.  Lei Zhang, Zhipan Yang, Yiming Liu, Meijuan Huang, Naihu Wu^* Analysis of gene expression in carrot somatic embryonic development by differential screening of a cDNA library. Progress in Natural Science 2002, 12(3) 261-265  (in Chinese)
77.  Lei Zhang, Fengqiu Diao, Zhipan Yang, Meijuan Huang, Naihu Wu^* Isolation and characterization of a new member of sucrose carrier cDNA from carrot by functional expression in yeast. Chinese Science Bulletin 2001, 46(14) 1190-1195  (in Chinese)
78.  Fengqiu Diao, Lei Zhang, Meijuan Huang, Naihu Wu^*  Isolation of development-related genes in somatic embryo radicle of carrot (Daucus carota L.) using modified cDNA RDA. Science in China, 2000, 43(1) 47-56
79. 许晶， 张雷， 梅长林     极性肾损伤肾小管再生修复调控的研究进展 中华肾脏病杂志  Chin J Nephrol. 2013, 29: 631-634   （综述）
80. 王超，张文翔，殷梦昕，张雷*  Hippo信号调控果蝇中肠稳态维持的机制研究 中国细胞生物学学报（领域前沿）Chinese Journal of Cell Biology,  2015，37（5）： 599-603  （综述）
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83. 顾远，张雷，余发星 Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制 遗传 Hereditas (Beijing), 2017, 39(7): 588-596 （综述）

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