代表性论文与综述--中国科学院分子细胞科学卓越创新中心

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Qi Xiong, Zhini Zhu, Tingting Li, Xiaotian Li, Zixuan Zhou, Yulin Chao, Chuanhui Yang, Suihan Feng, Qianhui Qu & Dianfan Li,Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling,Nat Struct Mol Biol.2025 Jan 17.
Feifei Zhang, Ryan D. Chow, Emily He, Chuanpeng Dong, Shan Xin, Daniyal Mirza, Yanzhi Feng, Xiaolong Tian, Nipun Verma, Medha Majety, Yueqi Zhang, Guangchuan Wang & Sidi Chen,Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy,Nat Biotechnol.2025 Jan 16.
Yanpu Wu, Xinyan Zhang, Liang Sun, Qingqing Wu, Xiaoping Liu, Yueyi Deng, Zhenzhen Lu, Zhongxia Li, Chaoming Deng, Ruikun He, Luyun Zhang, Rong Zeng, Xuguang Zhang, Luonan Chen, Xu Lin,Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study,Natl Sci Rev.2024 Nov 26.
Pengyu Fan, Xue-Ying Shang, Aixia Song, Shuo Chen, Run-Yuan Mao, Jingchuan Ma, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao, Lei Hong, Jiaxian Liu, Wei Xu, Wei Jiang, Hongjie Shen, Qi Zhang, Huijuan Yang, Xiao-Ming Meng, Fei Lan, Jingdong Cheng, Congling Xu, Peng Zhang, Hai Jiang & Fei Xavier Chen,Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition,Nat Chem Biol.2025 Jan 14.
Qian Ren, Wenhui Xing, Bo Jiang, Heng Feng, Xuye Hu, Jinlong Suo, Lijun Wang & Weiguo Zou,Tenascin-C promotes bone regeneration via inflammatory macrophages,Cell Death Differ.2025 Jan 10.
Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang, Juan He, Anuradha Gopalan, Dan Li, Yu Chen, Yarui Du, Guoliang Xu, Weiwei Yang, Chao Liang & Dong Gao,LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer,Cell Res.2025 Jan 2.
Xianle Shi, Yanjing Li, Hongwei Zhou, Xiukun Hou, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen & Jianlong Wang,DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells,Nat Commun.2024 Dec 30.
Hua Wang, Shijie Tang, Qibiao Wu, Yayi He, Weikang Zhu, Xinyun Xie, Zhen Qin, Xue Wang, Shiyu Zhou, Shun Yao, Xiaoling Xu, Chenchen Guo, Xinyuan Tong, Shuo Han, Yueh-Hung Chou, Yong Wang, Kwok-Kin Wong, Cai-Guang Yang, Luonan Chen, Liang Hu, Hongbin Ji,Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target,Natl Sci Rev.2024 Nov 7.
Hongxin Li, Shaohua Zhang, Xiuzhen Huang, Zhenqian Zhang, Kuo Liu, Qing-Dong Wang, Alex F. Chen, Kathy O. Lui, Kun Sun & Bin Zhou,Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis,Cell Discov.2024 Dec 3.
Lequn Wang, Xiaosheng Bai, Chuanchao Zhang, Qianqian Shi, Luonan Chen,Spatially Aware Domain Adaptation Enables Cell Type Deconvolution from Multi-Modal Spatially Resolved Transcriptomics,Small Methods.2024 Dec 2.
Guanchao Wang, Tiantian Lu, Lei Zhang & Jianping Ding,IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation,Nat Commun.2024 Nov 30.
Xinyi Xu, Haotian Chen, Zhengxu Ren, Xiaomin Xu, Wei Wu, Haochen Yang, JinJiao Wang, Yumeng Zhang, Qiuping Zhou, Hua Li, Shaoqing Zhang, Haopeng Wang, Chenqi Xu,Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity,Immunity.2024 Nov 27.
Xinwen Pan, Chuyu Fang, Chuan Shen, Xixia Li, Lele Xie, Luan Li, Shan Huang, Xiumin Yan & Xueliang Zhu,Directional ciliary beats across epithelia require Ccdc57-mediated coupling between axonemal orientation and basal body polarity,Nat Commun.2024 Nov 26.
Yangxia Tan, Jiawei Li, Shiyan Zhang, Yonglei Zhang, Zhiyi Zhuo, Xiaodan Ma, Yue Yin, Yanling Jiang, Yao Cong & Guoyu Meng,Cryo-EM structure of PML RBCC dimer reveals CC-mediated octopus-like nuclear body assembly mechanism,Cell Discov.2024 Nov 25.
Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Hu Zhou, Zhen Shao, Lingying Wu & Daming Gao,A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights,Nat Commun.2024 Nov 22.
Ling-Ling Chen, V Narry Kim,Small and long non-coding RNAs: Past, present, and future,Cell.2024 Nov 14.
Xiaoshen Zhang, Kai Xiao, Yaokai Wen, Fengying Wu, Guanghui Gao, Luonan Chen & Caicun Zhou,Multi-omics with dynamic network biomarker algorithm prefigures organ-specific metastasis of lung adenocarcinoma,Nat Commun.2024 Nov 14.
Peiwu Huang, Weina Gao, Changying Fu, Min Wang, Yunguang Li, Bizhu Chu, An He, Yuan Li, Xiaomei Deng, Yehan Zhang, Qian Kong, Jingxiong Yuan, Hebin Wang, Yu Shi, Dong Gao, Renyi Qin, Tony Hunter & Ruijun Tian,Clinical functional proteomics of intercellular signalling in pancreatic cancer,Nature.2024 Nov 13.
Wangxin Guo, Xiaoyu Zhang, Lin Li, Pengfei Shao, Chao Liang, Hongjiong Zhang, Kuo Liu, Shuoming Wang, Yunyi Peng, Jun Luo, Yi Ju, Angelo M De Marzo, Chen Yu, Luonan Chen, Bin Zhou, Dong Gao,JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination,Nat Genet.2024 Nov 13.
Rui Bi, Lin-Nuo Pan, Hao Dai, Chunli Sun, Cong Li, Hui-Juan Lin, Lan-Ping Xie, Huai-Xiao Ma, Lin Li, Heng Xie, Kun Guo, Chun-Hui Hou, Yong-Gang Yao, Luo-Nan Chen, Ping Zheng,Epigenetic characterization of adult rhesus monkey spermatogonial stem cells identifies key regulators of stem cell homeostasis,Nucleic Acids Res.2024 Nov 13.

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