1984年至1988就读于南京大学生物系，获学士学位。1992至1997年就读于美国迈阿密大学医学院生物化学与分子生物学系，获博士学位。1998年至2001年在美国普林斯顿大学分子生物学系接受博士后训练。2001年9月受聘于生物化学与细胞生物学研究所，任研究员，博士生导师，2002年2月至2007年1月，任中国科学院与德国马普学会合作的青年科学家小组组长。

实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。我们用酵母为模型，聚焦以下研究方向：

（1）构建“最小基因组”真核细胞；

（2）染色体末端的端粒复制、结构调控、进化；

（3）基因组（染色体）稳定性与细胞衰老机制。

( ^#共同第一作者, *通讯作者)

1.构建“最小基因组”真核细胞：

1. Xueting Zhu, Shaochun Liu, Tiantian Ye, Xin Gu, Feiyu Pu, Zhen Zhou, Zhi‑Jing Wu and Jin‑Qiu Zhou*. (2025) Artificial chromosome reorganization reveals high plasticity of the budding and fission yeast genomes. Genome Biology 26:229. https://doi.org/10.1186/s13059-025-03689-1.
2. Yuang Wang Y, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou* and Yun Zhao*. (2023) Chromosome territory reorganization through artificial chromosome fusion is compatible with cell fate determination and mouse development. Cell Discovery 9:11.
3. Xin Gu, Tiantian Ye, Xiao-Ran Zhang, Lingyun Nie, Huan Wang, Wei Li, Rui Lu, Chuanhai Fu, Li-Lin Du*and Jin-Qiu Zhou*. (2022) Single-chromosome fission yeast models reveal the configuration robustness of a functional genome. Cell Reports 40, 111237.
4. Zhi-Jing Wu, Jia-Cheng Liu, Xin Man, Xin Gu, Ting-Yi Li, Chen Cai, Ming-Hong He, Yangyang Shao, Ning Lu, Xiaoli Xue, Zhongjun Qin, Jin-Qiu Zhou*. (2020) Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions. eLife 2020;9:e53144 DOI: 10.7554/eLife.53144.
5. Yangyang Shao, Ning Lu, Chen Cai, Fan Zhou, Shanshan Wang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin*. (2019) A single circular chromosome yeast. Cell Research 29: 87-89.
6. Yangyang Shao, Ning Lu, Zhenfang Wu, Chen Cai, Shanshan Wang, Ling-Li Zhang, Fan Zhou, Shijun Xiao, Lin Liu, Xiaofen Zeng, Huajun Zheng, Chen Yang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin* (2018) Creating a functional single-chromosome yeast. Nature 560, 331-335.

2.染色体末端的端粒复制、结构调控、进化：

1. Tiantian Ye, Qingqing Yuan, Shuheng Wu, Jing-Tong Zhao, Zhi-Jing Wu, Jia-Cheng Liu, Wei Wu and Jin-Qiu Zhou*. (2025) Asymmetrical end structures of leading and lagging telomeres in Saccharomyces cerevisiae dictate the nature of the end replication problem. Cell Reports 44, 116622.
2. Can Hu, Xue-Ting Zhu, Ming-Hong He, Yangyang Shao, Zhongjun Qin, Zhi-Jing Wu*, Jin-Qiu Zhou*. (2024) Elimination of subtelomeric repeat sequences exerts little effect on telomere functions in Saccharomyces cerevisiae. eLife 12:RP91223. https://doi.org/10.7554/eLife.91223.4.
3. Yue Pan, Can Hu, Lin-Jun Hou, Yu-Long Chen, Jiantao Shi, Jia-Cheng Liu*, Jin-Qiu Zhou*. (2023) Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. DNA Repair 127, 103512.
4. Qian-Xi Li, Jia-Cheng Liu, Ming-Hong He and Jin-Qiu Zhou*. (2022) Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity. Biochemical Journal 479(23): 2433–2447.
5. Jia-Cheng Liu, Qian-Jin Li, Ming-Hong He, Can Hu, Pengfei Dai, Fei-Long Meng, Bo O. Zhou and Jin-Qiu Zhou*. (2020) Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes. Nucleic Acids Research  48(22): 12792–12803.
6. Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou*. (2018) Yeast KEOPS complex regulates telomere length independently of its t⁶A modification function. Journal of Genetics and Genomics 45(5): 247-257.
7. Zhenfang Wu*, Ming-Hong He, Ling-li Zhang, Jun Liu, Qiong-Di Zhang, Jin-Qiu Zhou*. (2018) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA Repair 72, 64-76.
8. Zhenfang Wu, Jun Liu, Qiong-Di Zhang, De-Kang Lv, Nian-Feng Wu and Jin-Qiu Zhou*. (2017) Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Research 45(6): 3308-3322.
9. Yi-Min Duan, Bo-O Zhou, Jing Peng, Xia-Jing Tong, Qiong-Di Zhang and Jin-Qiu Zhou*. (2016) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast. Journal of Genetics and Genomics 43(7): 451-465.
10. Xiao-Hong Fu^#, Yi-Min Duan^#, Yu-Ting Liu, Chen Cai, Fei-Long Meng, Jin-Qiu Zhou*. (2014) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors. PLoS One 9(3): e90644.
11. Yan Hu^#, Hong-Bo Tang^#, Ning-Ning Liu^#, Xia-Jing Tong, Wei Dang, Yi-Min Duan, Xiao-Hong Fu, Yang Zhang, Jing Peng, Fei-Long Meng, Jin-Qiu Zhou*. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genetics 9(1): e1003208.
12. Qian-Jin Li, Xia-Jing Tong, Yi-Min Duan, Jin-Qiu Zhou*. (2013) Characterization of the intramolecular G-quadruplex promoting activity of Est1. FEBS Letter 587(6): 659-665.
13. Jing Peng and Jin-Qiu Zhou*. (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Research 40(2): 581-593.
14. Xia-Jing Tong, Qian-Jin Li, Yi-Min Duan, Ning-Ning Liu, Ming-Liang Zhang, and Jin-Qiu Zhou*. (2011) Est1 protects telomeres and inhibits subtelomeric Y′-element recombination. Molecular and Cellular Biology 31(6): 1263-1274.
15. Bo O. Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A. Lenzmeier, Jin-Qiu Zhou*. (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLoS Genetics 7(1): e1001272.
16. Ning-Ning Liu, Tian Xu Han, Li-Lin Du and Jin-Qiu Zhou (2010) A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. Cell Research 20:963-965.
17. Fei-Long Meng, Xiao-Fen Chen, Yan Hu, Hong-Bo Tang, Wei Dang, Jin-Qiu Zhou (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Research 20:495-498.
18. Ming-Liang Zhang, Xia-Jing Tong, Xiao-Hong Fu, Bo O. Zhou, Jianyong Wang, Xin-Hua Liao, Qian-Jin Li, Ning Shen, Jianping Ding, Jin-Qiu Zhou*. (2010) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nature Structural & Molecular Biology 17(2): 202-209.
19. Wei Qian*, Xiao-Hong Fu, Jin-Qiu Zhou. (2010) Purification and characterization of Stn1p, a single-stranded telomeric DNA binding protein. Protein Expression and Purification 73: 107–112.
20. Fei-Long Meng, Yan Hu, Ning Shen, Xia-Jing Tong, Jianyong Wang, Jianping Ding and Jin-Qiu Zhou* (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. THE EMBO JOURNAL 28: 1466-1478.
21. Wei Qian, Jianyong Wang, Na-Na Jin, Xiao-Hong Fu, Yi-Chien Lin, Jing-Jer Lin, Jin-Qiu Zhou* (2009) Ten1p promotes the telomeric DNA binding acivity of Cdc13p: an implication for its function in telomere length regulation. Cell Research 19: 850-863.
22. Cui-Ping Yang, Yong-Bin Chen, Fei-Long Meng and Jin-Qiu Zhou* (2006) Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Research 34:407-416.
23. Deng-Hong Zhang, Bo Zhou, Yu Huang, Lu-Xia Xu and Jin-Qiu Zhou* (2006) The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Research 34:1393-1404.
24. Yong-Bin Chen, Cui-Ping Yang, Rong-Xia Li, Rong Zeng, and Jin-Qiu Zhou* (2005) Def1p is involved in telomere maintenance in budding yeast. The Journal of Biological Chemistry 280:24784-24791.
25. Xin-Hua Liao, Ming-Liang Zhang, Cui-Ping Yang, Lu-Xia Xu and Jin-Qiu Zhou* (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochemical Journal 390:169-176.
26. Jin-Qiu Zhou ^#, Haiyan Qi ^#, Vincent P. Schulz, Maria K. Mateyak, Ellen K. Monson, and Virginia A. Zakian* (2002) Schizosaccharomyces pombe pfh1(+) Encodes an Essential 5' to 3' DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases. Molecular Biology Of The Cell 13:2180-2191.
27. Andreas S. Ivessa ^#, Jin-Qiu Zhou ^#, Schulz VP, Monson EK and Zakian VA* (2002) Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes & Development 16:1383-1396.
28. Jin-Qiu Zhou, Ellen K Monson⁺, Shu-Chun Teng⁺, Vince P Schulz⁺, Virginia A. Zakian* (2000) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 289: 771-774.
29. Andreas S. Ivessa^#, Jin-Qiu Zhou ^# and Virginia A. Zakian* (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100: 479-489.

3.基因组（染色体）稳定性与细胞衰老机制：

1. Ting Gong^#, Xin Gu^#, Yu-Ting Liu, Zhen Zhou, Ling-Li Zhang, Yang Wen, Wei-Li Zhong, Guo-Liang Xu, Jin-Qiu Zhou*. (2020) Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation. Journal of Genetics and Genomics 47(2): 105-114.
2. Ming-Hong He^#, Jia-Cheng Liu^#, Yi-Si Lu, Zhi-Jing Wu, Ying-Ying Liu, Zhenfang Wu, Jing Peng, Jin-Qiu Zhou*. (2019) KEOPS complex promotes homologous recombination via DNA resection. Nucleic Acids Research 47(11): 5684-5697.
3. Ling-Li Zhang, Zhenfang Wu, Jin-Qiu Zhou*. (2018) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. Journal of Genetics and Genomics 45(9): 467-476.
4. Zhen Zhou^#, Yu-Ting Liu^#, Li Ma, Ting Gong, Ya-nan Hu, Hong-Tao Li, Chen Cai Ling-Li Zhang, Gang Wei and Jin-Qiu Zhou*. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife 6: e30178 DOI: 10.7554/eLife.30178
5. Xiaoguang Liu, Wei Wei, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li* and Jiemin Wong*. (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 3, 17016.
6. Jun Liu*, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu , Ting Gong, Hong-Tao Li, Jin-Qiu Zhou*. (2016) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast. Aging 8(11): 2827-2847.
7. Fengjuan Lv, Tianlong Zhang, Zhen Zhou, Shuaixin Gao, Catherine CL Wong, Jin-Qiu Zhou, Jianping Ding*. (2015) Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell Discovery 1, 15037.
8. Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen*, Jin-Qiu Zhou*. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochemical Journal 467(3): 507-515.
9. Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou*. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PLoS Genetics 11(3): e1005071.
10. Bo O. Zhou and Jin-Qiu Zhou*. (2011) Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation. The Journal of Biological Chemistry 286(40): 34770-34776.
11. Shan-Shan Wang, Bo O. Zhou*, and Jin-Qiu Zhou*. (2011) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 promoter. Molecular and Cellular Biology 31(15): 3171-3181.
12. Yiwei Liu^#, Hongda Huang^#, Bo O Zhou, Shan-Shan Wang, Yingxia Hu, Xu Li, Jianping Liu, Jianye Zang, Liwen Niu, Jihui Wu, Jin-Qiu Zhou, Maikun Teng, Yunyu Shi. (2010) Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing. Journal of Biological Chemistry 285:4251-62.
13. Bo O. Zhou, Shan-Shan Wang, Lu-Xia Xu, Fei-Long Meng, Yao-Ji Xuan, Yi-Min Duan, Jian-Yong Wang, Hao Hu, Xianchi Dong, Jianping Ding, and Jin-Qiu Zhou*. (2010) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation. Molecular and Cellular Biology 30(10): 2391-2400.
14. Jia-Lei Hu, Bo O. Zhou, Run-Rui Zhang, Kang-Ling Zhang, Jin-Qiu Zhou*, Guo-Liang Xu*. (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. PNAS 106: 187-192.
15. Xiao-Fen Chen, Fei-Long Meng, Jin-Qiu Zhou* (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genetics 5: e1000535.
16. Jing Zhou, Bo O. Zhou, Brian A. Lenzmeier and Jin-Qiu Zhou* (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Research 37: 3699-3713.
17. Xiao-Hong Fu, Fei-Long Meng, Yan Hu and Jin-Qiu Zhou* (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7:746-757.
18. Jin-Qiu Zhou, Hua He, Cheng-Keat Tan, Kathleen M. Downey, Antero G. So* (1997) The small subunit is required for functional interaction of DNA polymerase delta with the proliferating cell nuclear antigen. Nucleic Acids Research 27:1094-1099.
19. Jin-Qiu Zhou, Cheng-Keat Tan, Antero G. So, Kathleen M. Downey* (1996) Purification and characterization of the human catalytic subunit of human DNA polymerase delta expressed in baculovirus-infected insect cells. Journal of Biological Chemistry 271:29740-29745.

科普：

翻译：《抗衰老革命》，周金秋等译，“上海科学技术出版社”发行（ISBN 978-7-5478-588-3），原著《The Telomerase Revolution》（原著作者：Michael Fossel，出版商：BenBella Books Inc.）。

文章：细胞端粒藏着长寿的秘密（《人民日报》“科技大观”版），刘军，周金秋，《人民日报》，2015年5月4日，22 版