首页 全所PI名录
  • 周斌
  • 研究员，研究组长，博士生导师
  • E-mail: zhoubin@@sibcb.ac.cn
  • 实验室主页: http://zhoulab-tracing.sibcb.ac.cn
    个人简介：

  • 2002年毕业于浙江大学医学院临床医学系获得MD。2006年毕业于中国医学科学院中国协和医科大学获得PhD。2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究，并于2009年任哈佛大学医学院讲师和Research Associate。2010年9月起至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员，研究组长。2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员，研究组长。曾获得国际心脏研究会ISHR—“杰出研究员奖”、国家杰出青年科学基金、 “英国皇家学会-牛顿高级学者基金”、中国青年科技奖、中国科学院青年科学家奖、谈家桢生命科学创新奖、科学探索奖、上海市自然科学奖一等奖、上海市青年科技杰出贡献奖、新基石研究员、中科院青年科学家国际合作伙伴奖等。多次获得中国科学院“优秀研究生指导教师”称号、“中国科学院大学领雁奖”、“中科院优秀导师奖”、“朱李月华优秀教师”奖等。

    社会任职：
    研究方向：
  • 　　谱系示踪与细胞命运可塑性
    研究工作：

  • 研究组主要利用基于同源重组酶系统的遗传谱系示踪技术，在哺乳动物体内进行细胞标记及追踪来研究细胞起源及命运，揭示发育、疾病、再生过程中的细胞分化、增殖、衰老、死亡等细胞命运过程，并阐明细胞命运调控的分子机制，为相关疾病治疗提供重要理论基础和新的研究方向，解决了领域内多个重要科学问题，取得系统性原创成果。代表性研究工作发表在Cell、Nature、Science等国际学术期刊，其中发现哺乳动物新生期心脏具有重新生成冠状动脉的能力的成果入选“中国科学十大进展”;创建的谱系示踪新技术解决了近20年来国际心血管领域内关于心脏干细胞与心肌再生的争议问题;建立了双重组酶介导的遗传学技术和邻近细胞遗传学技术，从全新的角度揭示了器官发育与修复再生的调控机制。目前，我们的研究主要包括以下几个方面：

    1、建立和发展谱系示踪及遗传操作新技术，实现哺乳动物体内更为精准、高效地遗传示踪和操作，揭示器官发育与组织再生过程中细胞分化、增殖、衰老、死亡等过程，并阐明其遗传与表观遗传调控机制。

    2、建立邻近细胞遗传操作新技术，深入解析哺乳动物体内细胞-细胞交流过程，探索体内细胞微环境对干细胞命运调控的机理，为促进体内干细胞有效扩增和诱导分化提供理论基础。

    3、探索异种器官再造技术，致力于实现重要器官的异种再造，研究成果将来可以为人类器官再造和移植奠定重要理论基础和技术平台。

    实验室的长远目标是实现器官原位再生和异体器官再造，为相关疾病治疗提供新思路和新策略。


    　　研究组朝气蓬勃，积极向上，团结进取，学术气氛活跃，致力于成为 “严谨、团结、创新”的谱系示踪与细胞命运研究团队。近几年来，研究组每年都有学生获得国家奖学金、中科院院长奖、优秀毕业生、优秀博士论文等，培养的多位学生已赴国外顶尖学府(如哈佛大学等)从事博士后研究，或已在国内知名大学和科研院所任独立PI(如复旦大学、同济大学、西湖大学、上海科技大学、中科院药物所等)。

    承担科研项目情况：
    代表论著：

  • 2024

    1. Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, Jin H, Liu X, Shi M, Pu W, Werner M, Meister M, Kauschke S, Sun R, Wang J, Shen R, Wang Q, Ma X, Thors J, Zhou B*. Identifying specific functional roles for senescence across cell types. Cell 2024, doi.org/10.1016/j.cell.2024.09.021
    2. Liu K, Meng X, Liu Z, Tang M, Lv Z, Huang X, Jin H, Han X, Liu X, Pu W, Zhu H, Zhou B*. Tracing the origin of alveolar stem cells in lung repair and regeneration. Cell 2024;187:2428-2445.
    3. Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, Zhao H, Xi Y, Sui P, Vaughan A, Gillich A, Zhou B*. Alveolar regeneration by airway secretory cell-derived p63+ progenitors. 2024 Cell Stem Cell doi.org/10.1016/j.stem.2024.08.005
    4. Guo W, Zhang X, Li L, Shao P, Liang C, Zhang H, Liu K, Wang S, Peng Y, Luo J, Ju Y, De Marzo A*, Yu C*, Chen L*, Zhou B*, Gao D*. JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination. Nat Genet 2024 in press
    5. Liu K, Zhang S, Meng X, Li H, Zhu J, Wang E, Tang M, Zhang M, Zhou B*, Wang L*. Intercellular genetic tracing by alternative synthetic Notch signaling. Cell Discov 2024 in press
    6. Li Y, Liu Z, Han X, Liang F, Zhang Q, Huang X, Shi X, Huo H, Han M, Liu X, Zhu H, He L, Shen L, Hu X, Wang J, Wang Q, Smart N, Zhou B*, He B*. Dynamics of Endothelial Cell Generation and Turnover in Arteries during Homeostasis and Diseases. Circulation 2024;149:135-154.
    7. Zhang M, Lui K*, Zhou B*. Application of New Lineage Tracing Techniques in Cardiovascular Development and Physiology. Circ Res 2024;134:445-458.
    8. Yang G*, He Q, Guo X, Li RY, Lin J, Lang Y, Tao W, Liu W, Lin H, Xing S, Qi Y, Xie Z, Han JJ, Zhou B*, Teng Y*, Yang X*. Identification of the metaphyseal skeletal stem cell building trabecular bone. Sci Adv 2024;10:eadl2238.
    9. Shi M, Li J, Liu X, Liu K, Pu W, Weng W, Zhang S, Zhao H, Lui K, Zhou B*. The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo. ELife 2024 doi.org/10.7554/eLife.97717.1

    2023

    1. Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano L, Tchorz JS*, Zhou B*. Bipotent transitional liver progenitor cells contribute to liver regeneration. Nat Genet 2023;55(4):651-664. (Cover Story)
    2. Han M, Z L, Liu L, Huang X, Wang H, Pu W, Wang E, Liu X, Li Y, He L, Li X, Wu J, Qiu L, She R, Wang Q, Ji Y, Ardehali R, Shu Q, Lui KO, Wang L, Zhou B*. Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis. Nat Genet 2023;55(4):665-678.
    3. Liu K*, Jin H, Zhang S, Tang M, Meng X, Li Y, Pu W, Lui K, Zhou B*. Intercellular genetic tracing shows the lack of hematopoietic specification from cardiac endothelium in the developing heart. Dev Cell 2023;58(16):1502-1512.
    4. Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. Improved Factor Combination for In  Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing. Circulation 2023;148:1728-1731.
    5. Zhang S, Zhang Q, Liu Z, Liu K, He L, Lui KO, Wang L*, Zhou B*. Genetic dissection of intercellular interactions in vivo by membrane-permeable protein. PNAS 2023;120(1):e2120582120.
    6. Liu K, Tang M, Xu W, Meng X, Jin H, Han M, Pu J, Li Y, Jiao F, Sun R, Shen R, Lui K, Lu L*, Zhou B*. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo. PNAS 2013;120(25):e2207210120.
    7. Liu X, Weng W, He L*, Zhou B*. Genetic recording of in vivo cell proliferation by ProTracer. Nat Protoc 2023;18:2349-2373. Cover Story.
    8. Zhao H, Huang X, Liu Z, Lai L, Sun R, Shen R, Li Y, He L, Pu W, Lv Z, Li Y, Han X, Liu X, Zhou B*. Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas. Cell Discov 2023;9:1.
    9. Zhang M, Pu W, Li J, Han M, Han X, Zhang Z, Lv Z, Smart N, Wang L*, Zhou B*. Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart. Cell Discov 2023;9:9

    2022

    1. Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang R, Zhou B*. Monitoring of cell-cell communication and contact history in mammals. Science 2022;378(6623): eabo5503.
    2. Pu W, Zhang M, Liu X, He L, Li J, Han X, Lui KO, He B, Zhou B*. Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes. Circulation 2022;145:410-412.
    3. Han M, Liu Z, He L, Li X, Liu L, Huang X, Zhang M, Yan Y, Lui KO, Zhou B*. Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart. Circulation 2022;145:1179-1181.
    4. Tang J, Zhu H, Tian X, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Smart N, Gong H, Luo Q, Zhou B*. Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates. Circ Res 2022;130:352-365. (Cover story)
    5. Jin H, Liu K, Huang X, Huo H, Mou J, Qiao Z, He B, Zhou B*. Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circ Res 2022;130:1682-1697. (Cover story)
    6. Liu K, Jin H, Tang M, Zhang S, Tian X, Zhang M, Han X, Liu X, Tang J, Pu W, Li Y, He L, Yang Z, Lui K, Zhou B*. Lineage tracing clarifies the cellular origin of tissue resident macrophages in the developing heart. J Cell Biol 2022;221:e202108093.
    7. Wang H, He L, Li Y, Pu W, Zhang S, Han X, Lui K, Zhou B*. Dual recombinases mediate synchronized lineage tracing and cell subset ablation in vivo. J Bio Chem 2022;298:101965.

    2021

    1. He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang Q-D, Ji Y, Tchorz JS, Zhou B*. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science 2021;6532:eabc4346.
    2. Han X, Zhang Z, He L, Zhu H, Li Y, Pu W, Han M, Zhao H, Liu K, Li Y, Huang X, Zhang M, Jin H, Lv Z, Tang J, Wang J, Sun R, Fei J, Tian X, Duan S, Wang Q, Wang L, He B, Zhou B*. A suite of new Dre-recombinase drivers markedly expands the ability to perform intersection genetic targeting. Cell Stem Cell 2021;28:1-17.
    3. Zhao H, Huang X, Liu Z, Pu W, Lv Z, He L, Li Y, Zhou Q, Lui KO, Zhou B*. Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nat Metab 2021;3:352-365.
    4. Wang H, Zhao H, Zhu H, Li Y, Tang J, Li Y, Zhou B*. Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis. Circ Res 2021;128:133-135.
    5. Tian X*, Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution. J Biol Chem 2021;296: S0021-9258(21)00285-4.
    6. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B*. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021;592:606-610.
    7. Liu X, Pu W, He L, Li Y, Zhao H, Li Y, Liu K, Huang X, Weng W, Wang Q-D, Shen L, Zhong T, Sun K, Ardehali R, He B*, Zhou B*. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle. Nat Commun 2021;12(1):5784.
    8. Jin H, Liu K, Tang J, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B*. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun 2021; 12(1): 2863.
    9. Zhang S, Li Y, Huang X, Liu K, Wang QD, Chen AF, Sun K, Lui KO, Zhou B*. Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis. Circulation 2021;144:2004-2020.
    10. Li Y, Zhu H, Zhang Q, Han X, Zhang Z, Shen L, Wang L, Lui KO, He B, Zhou B*. Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque. Cell Discov 2021;7:111.
    11. Tang J, Zhu H, Liu S, Wang H, Huang X, Yan Y, Wang L, Zhou B*. Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury. Cell Discov 2021;7.
    12. Tian X, Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution. J Biol Chem 2021;296:100509.
    13. Weng W, Liu X, Lui KO, Zhou B*. Harnessing orthogonal recombinases to decipher cell fate with enhanced precision. Trends Cell Biol 2021S0962-8924(21)00186.
    14. Zhao H, Lui KO, Zhou B*. Pancreatic beta cell neogenesis: Debates and updates. Cell Metab 2021;33:2105-2107.

    2020

    1. Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L, Gao D, Zhou B*. Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020;26:81-96.e4.
    2. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B*. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020;54:593-607.e5.
    3. Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J*. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell 2020;52:617-630.e6.
    4. He L, Nguyen NB, Ardehali R, Zhou B*. Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. Circulation 2020;142:275-291.
    5. Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu YT, Xu C, Wei Y, Ding Q, Song BL, Huang H, Zhou B*. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation 2020;141:67-79.
    6. Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lyu A, Lazarus M, Breyer RM, Yu Y*. DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation 2020;141:655-666.
    7. Liu K, Tang M, Jin H, Liu Q, He L, Zhu H, Liu X, Han X, Li Y, Zhang L, Tang J, Pu W, Lv Z, Wang H, Ji H, Zhou B*. Triple-cell lineage tracing by a dual reporter on a single allele. J Biol Chem 2020;295:690-700.
    8. Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B*, Lui KO*. Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics 2020;10:8018-8035.
    9. Li H, Zhang Q, Gu Y, Wu Y, Wang Y, Wang L, Feng S, Hu Y, Zheng Y, Li Y, Ye H, Zhou B, Lin L, Liu M, Yang H, Li D*. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A 2020;117:33426-33435.
    10. Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, Zhu T, Ma F, Tang Q, Zhou B*, Zhu J*. Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier. Science Advances 2020;6:eaay8627.
    11. Han M, Zhou B*. Sox17 and Coronary Arteriogenesis in Development. Circ Res 2020;127:1381-1383.
    12. Pu W, Han X, Zhang M, Li Y, Huang X, He L, Zhou B*. Resident endothelial cells generate hepatocytes through cell fusion in adult mouse liver. J Genet Genomics 2020;47:225-228.
    13. Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W, Cheng H, He A*. Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution. Nat Cell Biol 2020;22:332-340.
    14. Li Y, Feng J, Song S, Li H, Yang H, Zhou B, Li Y, Yue Z, Lian H, Liu L, Hu S*, Nie Y*. gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration. Circulation 2020;142:967-982.
    15. Liu K, Jin H, Zhou B*. Genetic lineage tracing with multiple DNA recombinases: A user’s guide for conducting more precise cell fate mapping studies. J Biol Chem 2020;295:6413-6424.
    16. Tian X*, He L, Liu K, Pu W, Zhao H, Li Y, Liu X, Tang M, Sun R, Fei J, Ji Y, Qiao Z, Lui KO, Zhou B*. Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J 2020;39:e102675.
    17. Yin Q, Wang H, Li N, Ding Y, Xie Z, Jin L, Li Y, Wang Q, Liu X, Xu L, Li Q, Ma Y, Cheng Y, Wang K, Zhong C, Yu Q, Tang W, Chen W, Yang W, Zhang F, Ding C, Bao L, Zhou B, Hu P, Li J*. Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1. Cell Res 2020;30:133-145.
    18. Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA*, Metzger RJ*. Capillary cell-type specialization in the alveolus. Nature 2020;586（7831）:785-789.
    19. Liu K, Tang M, Liu Q, Han X, Jin H, Zhu H, Li Y, He L, Ji H, Zhou B*. Bi-directional differentiation of single bronchioalveolar stem cells during lung repair. Cell Discov 2020;6:1.
    20. Chu Q, Jiang H, Zhang L, Zhu D, Yin Q, Zhang H, Zhou B, Zhou W, Yue Z, Lian H, Liu L, Nie Y, Hu S*. CACCT: An Automated Tool of Detecting Complicated Cardiac Malformations in Mouse Models. Adv Sci (Weinh) 2020;7:1903592.
    21. Pu W, Han X, He L, Li Y, Huang X, Zhang M, Lv Z, Yu W, Wang QD, Cai D, Wang J, Sun R, Fei J, Ji Y, Nie Y, Zhou B*. A genetic system for tissue-specific inhibition of cell proliferation. Development 2020;147:dev183830.
    22. Brulois K, Rajaraman A, Szade A, Nordling S, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O’Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red-Horse K, Mebius RE, Adams RH, Kubes P, Pan J, Butcher EC*. A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nat Commun 2020;11:3798.

    2019

    1. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H*, Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 2019;51:728-738.
    2. He L, Han M, Zhang Z, Li Y, Huang X, Liu X, Pu W, Zhao H, Wang Q, Nie Y, Zhou B*. Reassessment of c-Kit Cells for Cardiomyocyte Contribution in Adult Heart. Circulation 2019;140:164-166.
    3. Li Y, Lv Z, He L, Huang X, Zhang S, Zhao H, Pu W, Li Y, Yu W, Zhang L, Liu X, Liu K, Tang J, Tian X, Wang Q-D, Lui KO, Zhou B*. Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res 2019;125:343-355.
    4. Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun 2019;10:4158.
    5. Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B*, Zhang L*. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet 2019;15:e1007977.
    6. Ni Z, Deng J, Potter CMF, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q, Hu Y, Zhou B, Xu Q, Zhang L*. Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models. Circ Res 2019;125:223-241.
    7. Han X, Wang Y, Pu W, Huang X, Qiu L, Li Y, Yu W, Zhao H, Liu X, He L, Zhang L, Ji Y, Lu J, Lui KO, Zhou B*. Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration. Stem Cell Reports 2019;12:624-638.
    8. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT*. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun 2019;10:4907.
    9. Chen Q, Liu Y, Jeong HW, Stehling M, Dinh VV, Zhou B, Adams RH*. Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Cell Stem Cell 2019;25:768-783.e6.
    10. Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, Zhou B, Chen J, Gao S, Zhang X, Jia M, Niu C, Yang W, Zhi X, Wang X, Yu D, Bai L, Wang L, Na J, Zou Y, Zhang J, Zhang S, Meng D*. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv 2019;5:eaau7887.
    11. Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H, Guo W, Yang X. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell 2019
    12. Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B*, Zhang H*. CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Circulation 2019;139:2495-2498.

    2018

    1. Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO, Zhou B*. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation 2018;138:793-805.
    2. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Pu W, Tian X, Nie Y, Hu S, Wang Q-D, Lui KO, Zhou B*. Fate Mapping of Sca1 Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation 2018;138:2967-2969.
    3. Zhang H, Lui KO, Zhou B*. Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration. Circ Res 2018;122:774-789.
    4. Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B*. Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart. Circ Res 2018;122:984-993.
    5. Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B*. Genetic Targeting of Organ-Specific Blood Vessels. Circ Res 2018;123:86-99.
    6. Zhang L, Issa Bhaloo S, Chen T, Zhou B*, Xu Q*. Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. Circ Res 2018;122:1608-1624.
    7. Zhou B, Wu SM*. Reassessment of c-Kit in Cardiac Cells: A Complex Interplay Between Expression, Fate, and Function. Circ Res 2018;123:9-11.
    8. Zhao ZA, Han X, Lei W, Li J, Yang Z, Wu J, Yao M, Lu XA, He L, Chen Y, Zhou B, Hu S*. Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts. Circ Res 2018;123:266-287.
    9. Li Y, Zhao H, Huang X, Tang J, Zhang S, Li Y, Liu X, He L, Ju Z, Lui KO, Zhou B*. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res 2018;28:775-778.
    10. Liu K, Yu W, Tang M, Tang J, Liu X, Liu Q, Li Y, He L, Zhang L, Evans SM, Tian X, Lui KO, Zhou B*. A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development 2018;145:dev167775.

    2017

    1. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med 2017;23:1488-1498.
    2. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 2017;127:2968-2981.
    3. Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ*. T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma. Circ Res 2017;120:1584-1597.
    4. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Sp？ter D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR*. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation 2017;135:59-72.
    5. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang Q-D, Wu SM, Pu WT, Anderson RH, Zhou B*. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 2017;8:759.
    6. Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 2017;27:1157-1177.
    7. Wang WE, Li L, Xia X, Fu W, Liao Q, Lan C, Yang D, Chen H, Yue R, Zeng C, Zhou L, Zhou B, Duan DD, Chen X, Houser SR, Zeng C*. Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation 2017;136:834-848.
    8. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH*. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;27:386-401.
    9. Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G*. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res 2017;27:386-401.
    10. He L, Zhou B*. Cardiomyocyte proliferation: remove brakes and push accelerators. Cell Res 2017;27:959-960.

    2016

    1. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet 2016;48:537-543.
    2. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium Contributes to Cardiac Fat. Circ Res 2016;118:254-265.
    3. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res 2016;118:1880-1893.
    4. Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y*. Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo. Circ Res 2016;118:1194-1207.
    5. Li G, Xu A, Sim S, Priest JR, Tian X, Khan T, Quertermous T, Zhou B, Tsao PS, Quake SR, Wu SM*. Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells. Dev Cell 2016;39:491-507.
    6. Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B*. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 2016;7:13369.
    7. Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B*. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res 2016;26:119-130.
    8. Xie C, Zhang YP, Song L, Luo J, Qi W, Hu J, Lu D, Yang Z, Zhang J, Xiao J, Zhou B, Du JL, Jing N, Liu Y, Wang Y, Li BL, Song BL, Yan Y*. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Res 2016;26:1099-1111.
    9. He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B*. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res 2016;109:419-430.
    10. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B*. GATA4 regulates Fgf16 to promote heart repair after injury. Development 2016;143:936-949.
    11. Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH*. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 2016;7:12422.
    12. Mondor I, Jorquera A, Sene C, Adriouch S, Adams RH, Zhou B, Wienert S, Klauschen F, Bajénoff M*. Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling. Immunity 2016;45:877-888.

    2015

    1. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B*. c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 2015;21:866-868.
    2. Tian X, Pu WT*, Zhou B*. Cellular Origin and Developmental Program of Coronary Angiogenesis. Circ Res 2015;116:515-530.
    3. Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y*. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-beta1 signaling. J Clin Invest 2015;125:1228-1242.
    4. Wei K, Serpooshan V, Hurtado C, Diez-Cunado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015;525:479-485.
    5. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B*. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015;6:6020.
    6. Zhang WC, Zheng XJ, Du LJ, Sun JY, Shen ZX, Shi C, Sun S, Zhang Z, Chen XQ, Qin M, Liu X, Tao J, Jia L, Fan HY, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan SZ*. High salt primes a specific activation state of macrophages, M(Na). Cell Res 2015;25:893-910.
    7. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ*. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest 2015;125:4122-4134.

    2014

    1. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science 2014;345:90-94.
    2. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B*. Epicardium-to-fat transition in injured heart. Cell Res 2014;24:1367-1369.
    3. Yang G, Zhu L, Hou N, Lan Y, Wu XM, Zhou B, Teng Y, Yang X*. Osteogenic fate of hypertrophic chondrocytes. Cell Res 2014;24:1266-1269.
    4. Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP*. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol 2014;16:841-851.
    5. Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K*. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest 2014;124:4899-4914.
    6. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B*. Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion. J Biol Chem 2014;289:18681-18692.
    7. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT*. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res 2014;115:354-363.

    2013

    1. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 2013;23:1075-1090.
    2. Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT*. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A 2013;110:15395-15400.

    2012

    1. Zhou B*, Pu WT*. Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles. Circ Res 2012;111:e276-e280.
    2. von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT*. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012;109:2394-2399.
    3. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ*. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res 2012;110:818-830.
    4. Wu KH, Han ZC, Mo XM, Zhou B*. Cell delivery in cardiac regenerative therapy. Ageing Res Rev 2012;11:32-40.

    2011 and before (Postdoc)

    1. Zhou B*, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT*. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011;121:1894-1904.
    2. Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X*. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest 2011;121:1585-1595.
    3. Zhou B, von Gise A, Ma Q, Hu YW, Pu WT*. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 2010;338:251-261.
    4. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009;119:1462-1476.
    5. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD*. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 2008;103:1393-1401.
    6. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT*. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008;454:109-113.
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