2010年毕业于哈尔滨工业大学，获学士学位;2017年毕业于中国科学院生物化学与细胞生物学研究所，获博士学位;2017年于哈佛大学医学院/波士顿儿童医院从事博士后研究(获CRI Irvington Postdoctoral Fellowship资助);2020年晋升为哈佛大学医学院讲师。2021年4月起担任中国科学院分子细胞科学卓越创新中心(中科院生化细胞所)研究员、研究组长、博士生导师。入选国家科技人才计划和上海市浦江人才计划。

　　近几年的突破性科学发现揭示了黏连蛋白(cohesin)通过染色质环挤压方式(loop extrusion)调控细胞核内一些生物学过程，如促进DNA损伤修复中心的形成，调控B淋巴细胞V(D)J重排等。这些发现表明如何精确调控染色质环挤压过程不仅是对基因组稳定性和抗体多样化至关重要，也是非常重要的生物学问题之一。

　　我们实验室主要以小鼠胚胎发育及淋巴细胞发育过程为研究内容，综合运用发育生物学、免疫学、表观遗传学和三维基因组学等技术方法，探索染色质三维结构变化与基因表达调控的关系。在未来几年，我们将聚焦于(但不局限于)染色质环挤压模型在生物体发育与疾病发生发展过程中的调控机理，为人类发育缺陷、自身免疫和淋巴瘤等疾病的防治提供新的理论依据及治疗靶点。

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3. Sai Luo, Jun Zhang, Alex JB Kreutzberger, Amanda Eaton, Robert J Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F Haynes, Frederick W. Alt. An Antibody from Single Human V_H-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology. (2022). DOI: 10.1126/sciimmunol.add5446.
4. LijunWang, Xiuling You, Dengfeng Ruan, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu, Weiguo Zou. TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. (2022) 13, 4709. https://doi.org/10.1038/s41467-022-32138-x.
5. Yu Zhang, Xuefei Zhang, Hai-Qiang Dai, Hongli Hu, Frederick W. Alt. The role of chromatin loop extrusion in antibody diversification. Nature Reviews Immunology. (2022). https://doi.org/10.1038/s41577-022-00679-3.
6. Hai-Qiang Dai^#*, Hongli Hu^#, Jiangman Lou, Adam Yongxin Ye, Zhaoqing Ba, Xuefei Zhang, Yiwen Zhang, Lijuan Zhao, Hye Suk Yoon, Aimee M. Chapdelaine-Williams, Nia Kyritsis, Huan Chen,Kerstin Johnson, Sherry Lin, Andrea Conte, Rafael Casellas, Cheng-Sheng Lee*, Frederick W. Alt*. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. (2021) 590, 338–343. 
   1. Recommended in Faculty Opinions.
7. Hai-Qiang Dai^#, Zhuoyi Liang^#, Amelia N. Chang^#, Aimee M. Chapdelaine-Williams, Beatriz Alvarado, Alex A. Pollen, Frederick W. Alt, Bjoern Schwer. Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. (2020) 15 (10), 3154-3181.
8. Zhaoqing Ba, Jiangman Lou, Adam Yongxin Ye, Hai-Qiang Dai, Edward W. Dring, Sherry G. Lin, Suvi Jain, Nia Kyritsis, Kyong-Rim Kieffer-Kwon, Rafael Casellas, Frederick W. Alt. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. (2020) 586, 305–310.
9. Hai-QiangDai^#*, Hongli Hu^#,JiangmanLou,Adam YongxinYe,Aimee M.Chapdelaine-Williams, NiaKyritsis, YiwenZhang, NicoleManfredonia, RachaelJudson, HuanChen, KerstinJohnson, SherryLin, ZhaoqingBa, AndreaConte, RafaelCasellas, Cheng-Sheng Lee*, Frederick W.Alt*. Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination. bioRxiv.(2020). https://doi.org/10.1101/2020.06.30.181222.
10. Amelia N. Chang^#, Zhuoyi Liang^#, Hai-Qiang Dai^#, Aimee M. Chapdelaine-Williams, Nick Andrews, Roderick T. Bronson, Bjoern Schwer, Frederick W. Alt. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. (2018) 563,126-130.
    1. Highlighted by Nature News & Views.
    2. Recommended in Faculty Opinions.
11. Suvi Jain, Zhaoqing Ba, Yu Zhang, Hai-Qiang Dai, Frederick W. Alt. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. (2018) 174 (1),102-116.
12. Hai-Qiang Dai^#, Bang’an Wang^#, Lu Yang^#, Jiajia Chen^#, Guochun Zhu, Meiling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun, Guoliang Xu. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signaling. Nature. (2016) 538, 528-532.
    1. Top 10 Achievements of Chinese Sciences in 2016.
    2. Recommended in Faculty Opinions.
13. Xiao Hu, Lei Zhang, Shiqing Mao, Zheng Li, Jiekai Chen, Runrui Zhang, Haiping Wu, Juan Gao, Fan Guo, Wei Liu, Guifang Xu, Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei, Guoliang Xu. Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell. (2014) 14, 512-522.