宋昕阳--中国科学院分子细胞科学卓越创新中心

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宋昕阳
研究员，研究组长，博士生导师
E-mail: xinyang.song@sibcb.ac.cn
实验室主页:

个人简介：

　　2007年毕业于中国药科大学生命科学与技术学院，获理学学士学位。2014年毕业于中科院上海生命科学研究院健康科学研究所(现上海营养与健康研究所)，获理学博士学位。2016至2021年于美国哈佛医学院免疫学系从事博士后研究。2021年6月起任中科院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)研究员，研究组长，博士生导师。

社会任职：

研究方向：

黏膜稳态与疾病

研究工作：

　　机体的黏膜表面存在大量与宿主免疫系统相互作用的共生微生物。这些微生物包括细菌，真菌，病毒以及少量原生生物，其基因组合集被称为微生物组。作为人体的“第二基因组”，其所编码的代谢通路可将来源于机体和食物的天然产物转化为包括萜类，脂类，寡糖，氨基酸以及脂肪酸衍生物在内的多种小分子代谢产物。此外，人体微生物组的代谢通路亦可对异生化合物如药物分子进行多种修饰。近年来，虽然高通量测序技术的发展使得鉴定或预测大量微生物来源的小分子及其生物合成相关基因成为可能，但我们仍不清楚这些小分子代谢产物所介导的信号网络调控宿主黏膜免疫系统发育与功能，进而影响机体生理与病理的内在机理。由此，本实验室的研究重点在于系统阐明各类微生物来源的小分子代谢产物调控宿主黏膜免疫稳态以及疾病易感性的分子机理。依据前期的分子机理研究，我们亦致力于开发基于共生微生物基因组编辑技术的新型诊断与治疗途径。
　　我们将利用无菌小鼠模型和小鼠遗传修饰或疾病模型，并结合免疫学，微生物学(特别是细菌遗传学)，分子生物学，基因组学，转录组学以及代谢组学等多学科技术手段开展以下三个方向的科学研究：
　　1. 黏膜免疫细胞发育，成熟的分子机理及其功能；
　　2. 共生微生物对于黏膜免疫细胞调控的分子机理；
　　3. 新型共生微生物基因组编辑工具的开发与应用。

承担科研项目情况：

代表论著：

1. Zhang H, Xie Y, Cao F, Song X*. 2024. Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions. Gut Microbes 16 (1), 2382336. (* Correspondence author, Invited review)
2. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X*, Zhu S*, Pan W*. 2024. Enterococcus-derived tyramine hijacks a2A-adrenergic receptor in intestinal stem cells to exacerbate colitis. Cell Host Microbe 32 (6), 950-963. e8. (* Co-correspondence author)
3. Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. 2024. Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8⁺ T cell effector functions. Immunity 57 (4), 876–889. e11.
4. Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed JD, Ringel A, Barends J, Wu C, Balskus EP, Thiagarajah JR, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper S. 2024. Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol 18 (2):101350.
5. Xie Y, Zhang H, Song X*. 2024. AEP promotes aberrant RNA splicing through DDX3X cleavage in solid tumors. J Clin Invest 134 (3):e177609. (* Correspondence author, Invited commentary)
6. Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL. 2024. Gut complement induced by the microbiota combats pathogens and spares commensals. Cell 187 (4), 897–913. e18.
7. Peng H, Qiu J, Zhou Q, Zhang Y, Chen Q, Yin Y, Su W, Yu S, Wang Y, Cai Y, Gu M, Zhang H, Sun Q, Hu G, Wu Y, Liu J, Chen S*, Zhu Z*, Song X*, Zhou J*. 2023. Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis. Immunity 56 (12), 2773–2789. e8. (* Co-correspondence author)
8. Song X^†*, Zhang H^†, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W, Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF & Kasper DL*. 2023. Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature 619 (7971), 837-843. († Co-first author, * Co-correspondence author)
9. Yang T, Wang G, Zhang M, Hu X, Li Q, Yun F, Xing Y, Song X, Zhang H, Hu G, Qian Y. 2023. Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis. Cell Rep 42 (11):113377.
10. Song X*, Sun X*, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. 2020. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. Nature 577 (7790), 410-415. (* Co-first author)
11. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh SF, Mekalanos J, Kasper DL. 2020. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature 577 (7791), 543–548.
12. Yang D, Xing Y, Song X, Qian Y. 2020. The impact of lung microbiota dysbiosis on inflammation. Immunology 159 (2), 156-166.
13. Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y. 2019. Dysregulated lung commensal bacteria drive Interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles. Immunity 50 (3), 692-706. e7.
14. Zhang Y, Xin D, Wang Z, Song X, Sun Y, Zou Q, Yue J, Zhang C, Zhang J, Liu Z, Zhang X, Zhao T, Su B, Chin Y. 2019. STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J 38 (6):e99595.
15. Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y. 2018. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med 215 (11), 2850-2867.
16. Cao M, Chen F, Xie N, Cao M, Chen P, Lou Q, Zhao Y, He C, Zhang S, Song X, Sun Y, Zhu W, Mou L, Luan S & Gao H. 2018. c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and-independent activities. Cell Death Dis 9 (12):1140.
17. Shao X, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. 2017. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep 7 (1), 7024. (* Co-correspondence author)
18. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y. 2017. Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nature Commun 8 (1), 15402.
19. Song X*, He X*, Li X, Qian Y. 2016. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 13 (4), 418-431. (Invited review, * Co-first author)
20. Song X*, Dai D*, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. 2015. Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage. Immunity 43 (3), 488–501. (* Co-first author)
21. Song X*. 2015. Intestinal microbiota mining: a Th17/Treg cell perspective. Eur J Bio Med Res 1 (4), 28-35. (Invited review, * Correspondence author)
22. Song X*, Gao H*, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40 (1), 140-152. (* Co-first author)
23. Song X, Gao H, Qian Y. 2014. Chapter V: Th17 differentiation and their pro-inflammation function. Springer Press. Adv Exp Med Biol 841:99-151. (Invited book chapter)
24. Song X, Qian Y. 2013. Peli1 sets the CNS on fire. Nat Med 19 (5):536-538. (Invited preview)
25. Song X, Qian Y. 2013. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal 25 (12):2335-2347. (Invited review)
26. Song X, Qian Y. 2013. The activation and regulation of IL-17 receptor-mediated signaling. Cytokine 62 (2):175-182. (Invited review)
27. Zhu S, Pan W, Song X, Liu Y, Tang Y, Wang H, Liu W, Shi Y, He D, J.B Harley, Shen N, Qian Y. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 18 (7):1077-1086.
28. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 12 (12):1151-1158.
29. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 207 (12):2647-2662.

个人简介：

社会任职：

研究方向：

研究工作：

承担科研项目情况：

代表论著：

获奖及荣誉：

研究组成员：