赵祥--中国科学院分子细胞科学卓越创新中心

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赵祥
研究员，研究组长，博士生导师
E-mail: xiang.zhao@sibcb.ac.cn
实验室主页:

个人简介：

2009-2013年，复旦大学生命科学学院，生物科学学士
2013-2018年，新加坡国立大学医学院，免疫学博士
2018-2023年，斯坦福大学医学院，博士后
2023年6月起任中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）研究员，研究组长，博士生导师

社会任职：

研究方向：

T细胞免疫与T细胞受体

研究工作：

T细胞受体（TCR）结合配体peptide-MHC，是免疫系统识别多种多样抗原的分子基础。课题组综合运用生物化学、细胞生物学、免疫学、蛋白质工程、结构生物学、遗传学、生物物理学等方法，以T细胞与T细胞受体为主要研究对象，深入研究T细胞受体的抗原识别与信号转导机制，发展针对实体肿瘤的TCR-T细胞疗法。
具体方向包括：
　　1.T细胞受体抗原识别与信号转导的新机制;
　　2.T细胞受体等免疫受体的蛋白质工程改造新技术;
　　3.T细胞抗原识别与信号转导的结构基础;
　　4.多学科赋能的实体肿瘤特异TCR-T细胞疗法;
　　5.鉴定新型的免疫受体-配体。
主持项目：
　　国家自然科学基金委员会原创探索计划(主持，2024-2026)
　　中国科学院率先行动(主持，2024-2026)
　　上海市白玉兰人才计划浦江项目(主持，2023-2025)

承担科研项目情况：

代表论著：

1. Zhao*, X., Shao, S., and Hu, L. (2024). The recent advancement of TCR-T cell therapies for cancer treatment. Acta Biochim. Biophys. Sin. https://doi.org/10.3724/abbs.2024034.
2. Ren, F., Wang, F., Baghdasaryan, A., Li, Y., Liu, H., Hsu, R., Wang, C., Li, J., Zhong, Y., Salazar, F., et al. (2024). Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses. Nat. Biomed. Eng. 8, 726–739. https://doi.org/10.1038/s41551-023-01083-5.
3. Yang, X., Nishimiya, D., Löchte, S., Jude, K.M., Borowska, M., Savvides, C.S., Dougan, M., Su, L., Zhao, X., Piehler, J., et al. (2023). Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy. Nat Biotechnol, 1–12. https://doi.org/10.1038/s41587-022-01567-w.
4. Chan, W., Cao, Y.M., Zhao, X., Schrom, E.C., Jia, D., Song, J., Sibener, L.V., Dong, S., Fernandes, R.A., Bradfield, C.J., et al. (2023). TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. J. Exp. Med. 220, e20231242. https://doi.org/10.1084/jem.20231242.
5. Zhao, X., Kolawole, E.M., Chan, W., Feng, Y., Yang, X., Gee, M.H., Jude, K.M., Sibener, L.V., Fordyce, P.M., Germain, R.N., et al. (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.) 376, eabl5282. https://doi.org/10.1126/science.abl5282.Nat Rev Drug Discov综述点评Nat Rev Clin Oncol综述点评F1000推荐美国授权PCT专利PCT/US2022/018975
6. Yang, X., Garner, L.I., Zvyagin, I.V., Paley, M.A., Komech, E.A., Jude, K.M., Zhao, X., Fernandes, R.A., Hassman, L.M., Paley, G.L., et al. (2022). Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 1–7. https://doi.org/10.1038/s41586-022-05501-7.
7. Yen, M., Ren, J., Liu, Q., Glassman, C.R., Sheahan, T.P., Picton, L.K., Moreira, F.R., Rustagi, A., Jude, K.M., Zhao, X., et al. (2022). Facile discovery of surrogate cytokine agonists. Cell. https://doi.org/10.1016/j.cell.2022.02.025.
8. Feng, Y., Zhao, X., White, A.K., Garcia, K.C., and Fordyce, P.M. (2022). A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation. Nat Methods, 1–11. https://doi.org/10.1038/s41592-022-01592-2.
9. Wu, L., Balyan, R., Brzostek, J., Zhao, X., and Gascoigne, N.R.J. (2022). Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response. Embo Rep, e54969. https://doi.org/10.15252/embr.202254969.
10. Zhao, X., Wu, L.-Z., Ng, E.K.Y., Leow, K.W.S., Wei, Q., Gascoigne, N.R.J., and Brzostek, J. (2021). Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck. Frontiers in immunology 12, 721722. https://doi.org/10.3389/fimmu.2021.721722.
11. Brzostek, J., Gautam, N., Zhao, X., Chen, E.W., Mehta, M., Tung, D.W.H., Chua, Y.L., Yap, J., Cho, S.H., Sankaran, S., et al. (2020). T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis. Nature immunology 21, 186–198. https://doi.org/10.1038/s41590-019-0570-3.
12. Wei, Q., Brzostek, J., Sankaran, S., Casas, J., Hew, L.S.-Q., Yap, J., Zhao, X., Wojciech, L., and Gascoigne, N.R.J. (2020). Lck bound to coreceptor is less active than free Lck. Proceedings of the National Academy of Sciences of the United States of America 117, 15809–15817. https://doi.org/10.1073/pnas.1913334117.
13. Zhao, X., Hamidinia, M., Choo, J.A.L., Too, C.T., Ho, Z.Z., Ren, E.C., Bertoletti, A., MacAry, P.A., Gould, K.G., Brzostek, J., et al. (2019). Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation. J. Vis. Exp. https://doi.org/10.3791/59126-v.
14. Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019). In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Nature biotechnology 37, 1322–1331. https://doi.org/10.1038/s41587-019-0262-4.
15. Zhao, X., Sankaran, S., Yap, J., Too, C.T., Ho, Z.Z., Dolton, G., Legut, M., Ren, E.C., Sewell, A.K., Bertoletti, A., et al. (2018). Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature communications 9, 2716. https://doi.org/10.1038/s41467-018-05288-0.

个人简介：

社会任职：

研究方向：

研究工作：

承担科研项目情况：

代表论著：

获奖及荣誉：

研究组成员：