赵祥--中国科学院分子细胞科学卓越创新中心

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赵祥
研究员，研究组长，博士生导师
E-mail: xiang.zhao@sibcb.ac.cn
实验室主页: https://zhaoxianglab.sibcb.ac.cn

个人简介：

2009-2013年，复旦大学生命科学学院，生物科学学士
2013-2018年，新加坡国立大学医学院，免疫学博士
2018-2023年，斯坦福大学医学院，博士后
2023年6月起任中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）研究员，研究组长，博士生导师

社会任职：

研究方向：

T细胞免疫与T细胞受体

研究工作：

T细胞受体（TCR）结合配体peptide-MHC，是免疫系统识别多种多样抗原的分子基础。课题组综合运用生物化学、细胞生物学、免疫学、蛋白质工程、结构生物学、遗传学、生物物理学等方法，以T细胞与T细胞受体为主要研究对象，深入研究T细胞受体的抗原识别与信号转导机制，发展针对实体肿瘤的TCR-T细胞疗法。
具体方向包括：
　　1.T细胞受体抗原识别与信号转导的新机制;
　　2.T细胞受体等免疫受体的蛋白质工程改造新技术;
　　3.T细胞抗原识别与信号转导的结构基础;
　　4.多学科赋能的实体肿瘤特异TCR-T细胞疗法;
　　5.鉴定新型的免疫受体-配体。
主持项目：
　　国家自然科学基金委员会原创探索计划(主持，2024-2026)
　　中国科学院率先行动(主持，2024-2026)
　　上海市白玉兰人才计划浦江项目(主持，2023-2025)

承担科研项目情况：

代表论著：

1. Wang, Y., Wang, Y., Yuan, W., Fan, M., Wang, X., Wang, A., Bao, Y., Zhang, Y., Tan, J.C., Wang, J., Liu, J., Huang T., Han Z., Pei B., Chen L., Ren Z., Wang X., Hu L., Wu S., Pang M., Wang S., Yang Z., Li J., Huang D., Shao S., Yuan H., Wu L., Feng Y., Zhou P., Li G., Sun B., Xu C., Gascoigne N., Zhao*, X. (2026). Tuning the sensitivity of mechanosensory receptors through histidine scanning. Cell. https://doi.org/10.1016/j.cell.2025.12.050.
2. Fan, M., and Zhao*, X. (2025). Role of the neurotransmitter-receptor pathway in T-cell tumor immunology and cancer immunotherapy. Acta Biochim. Biophys. Sin. https://doi.org/10.3724/abbs.2025216
3. Zhao*, X., Shao, S., and Hu, L. (2024). The recent advancement of TCR-T cell therapies for cancer treatment. Acta Biochim. Biophys. Sin. https://doi.org/10.3724/abbs.2024034.
4. Ren, F., Wang, F., Baghdasaryan, A., Li, Y., Liu, H., Hsu, R., Wang, C., Li, J., Zhong, Y., Salazar, F., et al. (2024). Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses. Nat. Biomed. Eng. 8, 726–739. https://doi.org/10.1038/s41551-023-01083-5.
5. Yang, X., Nishimiya, D., Löchte, S., Jude, K.M., Borowska, M., Savvides, C.S., Dougan, M., Su, L., Zhao, X., Piehler, J., et al. (2023). Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy. Nat Biotechnol, 1–12. https://doi.org/10.1038/s41587-022-01567-w.
6. Chan, W., Cao, Y.M., Zhao, X., Schrom, E.C., Jia, D., Song, J., Sibener, L.V., Dong, S., Fernandes, R.A., Bradfield, C.J., et al. (2023). TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. J. Exp. Med. 220, e20231242. https://doi.org/10.1084/jem.20231242.
7. Zhao, X., Kolawole, E.M., Chan, W., Feng, Y., Yang, X., Gee, M.H., Jude, K.M., Sibener, L.V., Fordyce, P.M., Germain, R.N., et al. (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.) 376, eabl5282. https://doi.org/10.1126/science.abl5282.Nat Rev Drug Discov综述点评Nat Rev Clin Oncol综述点评F1000推荐美国授权PCT专利PCT/US2022/018975
8. Yang, X., Garner, L.I., Zvyagin, I.V., Paley, M.A., Komech, E.A., Jude, K.M., Zhao, X., Fernandes, R.A., Hassman, L.M., Paley, G.L., et al. (2022). Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 1–7. https://doi.org/10.1038/s41586-022-05501-7.
9. Yen, M., Ren, J., Liu, Q., Glassman, C.R., Sheahan, T.P., Picton, L.K., Moreira, F.R., Rustagi, A., Jude, K.M., Zhao, X., et al. (2022). Facile discovery of surrogate cytokine agonists. Cell. https://doi.org/10.1016/j.cell.2022.02.025.
10. Feng, Y., Zhao, X., White, A.K., Garcia, K.C., and Fordyce, P.M. (2022). A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation. Nat Methods, 1–11. https://doi.org/10.1038/s41592-022-01592-2.
11. Wu, L., Balyan, R., Brzostek, J., Zhao, X., and Gascoigne, N.R.J. (2022). Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response. Embo Rep, e54969. https://doi.org/10.15252/embr.202254969.
12. Zhao, X., Wu, L.-Z., Ng, E.K.Y., Leow, K.W.S., Wei, Q., Gascoigne, N.R.J., and Brzostek, J. (2021). Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck. Frontiers in immunology 12, 721722. https://doi.org/10.3389/fimmu.2021.721722.
13. Brzostek, J., Gautam, N., Zhao, X., Chen, E.W., Mehta, M., Tung, D.W.H., Chua, Y.L., Yap, J., Cho, S.H., Sankaran, S., et al. (2020). T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis. Nature immunology 21, 186–198. https://doi.org/10.1038/s41590-019-0570-3.
14. Wei, Q., Brzostek, J., Sankaran, S., Casas, J., Hew, L.S.-Q., Yap, J., Zhao, X., Wojciech, L., and Gascoigne, N.R.J. (2020). Lck bound to coreceptor is less active than free Lck. Proceedings of the National Academy of Sciences of the United States of America 117, 15809–15817. https://doi.org/10.1073/pnas.1913334117.
15. Zhao, X., Hamidinia, M., Choo, J.A.L., Too, C.T., Ho, Z.Z., Ren, E.C., Bertoletti, A., MacAry, P.A., Gould, K.G., Brzostek, J., et al. (2019). Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation. J. Vis. Exp. https://doi.org/10.3791/59126-v.
16. Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019). In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Nature biotechnology 37, 1322–1331. https://doi.org/10.1038/s41587-019-0262-4.
17. Zhao, X., Sankaran, S., Yap, J., Too, C.T., Ho, Z.Z., Dolton, G., Legut, M., Ren, E.C., Sewell, A.K., Bertoletti, A., et al. (2018). Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature communications 9, 2716. https://doi.org/10.1038/s41467-018-05288-0.

个人简介：

社会任职：

研究方向：

研究工作：

承担科研项目情况：

代表论著：

获奖及荣誉：

研究组成员：