首页 全所PI名录
  • 邹卫国
  • 研究员,研究组长,博士生导师
  • E-mail: zouwg94@@sibcb.ac.cn
  • 实验室主页: 
    个人简介:
  •   1998年本科毕业于南开大学生物化学系,2003年中科院生物化学与细胞生物学研究所获得理学博士学位。随后在美国Scripps研究所和美国哈佛大学公共卫生学院进行博士后研究(受美国白血病淋巴瘤协会资助)。2009年获选哈佛大学公共卫生学院Yerby Fellow。2012年获聘美国康纳尔大学和纽约州立大学布法罗分校Tenure Track助理教授职位。2012年8月回中科院生物化学与细胞生物学研究所工作,任研究员,研究组长,博士生导师。获得国家自然科学基金委杰出青年科学基金资助,国家科技部基础科学重大研究计划子课题负责人,中国科学院战略性先导科技专项(B类)子课题负责人,中华医学会骨科分会再生医学青年委员会组长,中华医学会骨矿盐与骨质疏松分会基础组常委,中国生物工程学会转化医学分会常委等。

    社会任职:
  •  
    研究方向:
  • 干细胞和运动系统衰老机制
    研究工作:
  •   间充质干细胞是一种多能干细胞,可以分化为成骨细胞、软骨细胞、脂肪细胞、肌肉细胞等。运动系统功能性干细胞包括膜内成骨的骨膜干细胞、软骨内成骨的骨干细胞、关节软骨干细胞、肌腱干细胞、肌肉干细胞等。间充质干细胞/运动系统功能性干细胞向不同组织细胞的分化受到多种遗传因素和表观遗传因素的影响,并受多种信号途径调控。调控因素的异常将导致多种疾病,包括先天性发育畸形、运动系统退行性疾病如骨质疏松症、骨性关节炎以及肌腱疾病等。

      研究组通过综合运用生物化学、分子生物学和动物模型等多种研究手段,建立了间充质干细胞向多种细胞分化的体外高通量筛选系统,研究干细胞增殖分化的分子机制及多种相关疾病的致病机理,并通过分子遗传学手段建立骨骼早衰、力学感知失调、关键干细胞稳态失调等多种动物模型,模拟骨质疏松、骨关节炎、骨折等常见骨科疾病,阐明其中的关键机制。

      实验室近期研究方向包括:

      1)鉴定运动系统功能性干细胞,研究功能性干细胞的自我更新及体内、体外多能性维持的机理。研究运动系统组织损伤中功能干细胞的扩增、再生以及谱系转换和调控机制。

      2)研究机械力对间充质干细胞/运动系统功能性干细胞功能的调控及其分子机制。

      3)研究间充质干细胞/运动系统功能性干细胞的衰老与疾病的关联及分子机制。

    承担科研项目情况:
  •  
    代表论著:
    1. Feng H#, Xing W#, Han W#, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W*. (2020) Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 130(12): 6354-6365.
    2. Sun J#, Feng H#, Xing W, Han Y, Suo J, Yallowitz A, Qian N, Shi Y, Greenblatt M, Zou W*. (2020) Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science Advances. 6(45): eaaz1410.
    3. Suo J#, Feng X#, Li J, Wang J, Wang Z*, Zhang L*, Zou W*. (2020) VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 6(43): eaba4147.
    4. Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W*. (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 11: 282.
    5. Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, Dai Q, Yang Y, Han A, Wei Z, Bi Q, Ji H, Kang T *, Zou W*. (2019) Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. Journal of Clinical Investigation. 129: 1895-1909.
    6. Bai M, Han Y, Wu Yu, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W*, Li J*. (2019) Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 17: e3000350.
    7. Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W*. (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 16: e2006522.
    8. Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
    9. Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
    10. Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*. (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation. 24: 1886–1899.
    11. Dai Q, Xie F, Han Y, Ma X, Zhou S, Jiang L*, Zou W.* Wang J*. (2017) Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice. Journal of Biological Chemistry. 292: 196–204.
    12. Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
    13. Niu N, Xiang JF, Yang Q, Wang L, Wei Z, Chen LL, Yang L, Zou W*. (2017) RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discovery. 3: 16050.
    14. Niu N, Shao R, Yan G, Zou W*. (2016) Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. Journal of Biological Chemistry. 291: 26647–26657.
    15. Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research. 26: 699-712.
    16. Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*. (2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications. 7: 11149.
    17. Zou W*, Greenblatt MB, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi SP, Baron R, Glimcher LH, Jones DC. (2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. Journal of Experimental Medicine. 210: 1793-806.
    18. Zou W, Chen X., Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones DC*. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13: 59–65.
    19. Zou W#, Greenblatt MB#, Shim JH, Kant S, Zhai B, Brady B, Hu DZ, Gygi SP, Davis R, Jones DC, Glimcher LH*. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. Journal of Clinical Investigation. 121: 4383-92.
    20. Wan L#, Zou W#, Gao D, Inuzuka H, Drapp R, Shaik S, Eguren M, Hu D, Malumbres M, Glimcher LH, Wei W*. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44: 721-33.
    21. Zou W, Zhang D*. (2006). The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. Journal of Biological Chemistry. 281: 3989-3994.
    22. Zou W, Luo C, Zhang Z, Liu J, Gu J, Pei Z, Qian C, Liu X*. (2004). A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent antitumoral efficiency. Oncogene 23: 457-464.
    23. Zhang Z#, Zou W#, Luo C, Li B, Wang J, Sun L, Qian Q, Liu X*. (2003). An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Research. 13: 481-489.
    24. Zou W#, Zeng J#, Zhuo M, Xu W, Sun L, Wang J, Liu X*. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. Journal of Neuroscience Research. 67: 837-843.
    25. Zou W, Yan M, Xu W, Huo H, Sun L, Zheng Z, Liu X*. (2001). Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. Journal of Neuroscience Research. 64: 646-653.
    获奖及荣誉:
  •  
    研究组成员:
  •