首页 全所PI名录
  • 丁建平
  • 研究员,研究组长,博士生导师
  • E-mail: jpding@@sibcb.ac.cn
  • 实验室主页: 
    个人简介:
  •   1982年1月南京大学获理学学士学位;1984年10月中山大学获理学硕士学位;1987年10月复旦大学获理学博士学位。1987年11月至1989年6月,中国科学院上海硅酸盐研究所博士后。1989年7月至1991年8月,联邦德国柏林自由大学结晶学研究所洪堡基金会奖研金学者。1991年9月至2000年10月,美国新泽西州罗格斯大学,先后任化学与化学生物学系研究助理、研究助理教授、研究副教授。2000年11月起,任中科院上海生科院生化与细胞所研究员、博士生导师。获得国家杰出青年基金(2001年)资助,2006年入选国家人事部“新世纪百千万人才工程”国家级人选。目前主要学术任职包括:“国际生化与分子生物学联盟”(IUBMB)“学术大会和专题会议委员会”委员(2019年-今);“亚洲晶体学会”理事(2006年-今);“中国晶体学会”理事(2003年-今)、“生物大分子专业委员会” 副主任委员(2012年-今);“中国生物物理学会”监事会监事长(2017年-今);“上海市生物物理学会”常务理事(2006年-今)、理事长(2014年-今)、“分子生物物理和结构生物学专业委员会” 主任委员(2006年-今)、 “中国生物化学与分子生物学会”常务理事、副秘书长(2018年-今) 等。中国《生物化学与生物物理学报》编委(2006年-今);《生物化学与生物物理进展》编委(2005年-今);《生命的化学》编委(2006年-今)等。

    社会任职:
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    研究方向:
  • 真核基因表达调控的结构生物学
    研究工作:
  •   真核生物的基因表达是一个非常复杂的过程,在基因转录、mRNA加工和运输、蛋白质翻译等层次上受到多种方式的调控,表达调控的异常会导致细胞的非正常生长、发育和分化,产生多种疾病包括肿瘤。我们研究组主要针对参与染色质修饰、mTOR信号转导通路和生物代谢通路调控的重要蛋白质和蛋白质复合物,运用结构生物学、分子生物学、生物化学、细胞生物学等方法,开展蛋白质的结构、功能和分子机制的研究。这些研究工作不仅能促进人们对参与真核基因表达调控的一些重要蛋白质的生物功能、分子机理、结构和功能关系的认识,同时也能为探索与这些蛋白质的功能失调相关疾病的发病机理、寻找疾病诊断的新靶标和新方法、设计和研发治疗疾病的药物等奠定分子基础。近年来主持、参与并完成国家、科学院和地方政府的多项重大研究项目。在国际重要学术刊物上发表研究论文170多篇、近五年来发表研究论文30多篇,其中包括Science、Sci Advances、Nature、Nature Struct Mol Biol、Nature Comm、Blood、PNAS、EMBO J、EMBO Rep、Cell Res、Cell Rep、Nucleic Acids Res、eLife、J Biol Chem、Structure、Biochem J等。

    承担科研项目情况:
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    代表论著:
  • 2015年至今发表的代表性研究论文(*通讯作者):

    1. Tianlong Zhang$, Marie-Pierre Péli-Gulli$, Zhen Zhang, Xing Tang, Jie Ye, Claudio De Virgilio*, and Jianping Ding* “Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases”, Sci. Adv., 8:3146 (2019). ($Contributed equally)
    2. Pengkai Sun, Tengfei Ma, Tianlong Zhang, Hanwen Zhu, Jianyang Zhang, and Jianping Ding* “Molecular basis for the function of the ab heterodimer of human NAD-dependent isocitrate dehydrogenase”, J. Biol. Chem., 294: 16214-16227 (2019).
    3. Wenjing Li, Yu Shi, Tianlong Zhang, Jie Ye, and Jianping Ding* “Structural insights into human N6amt1-Trm112 complex functioning as a protein methyltransferase”, Cell Discovery, 5:51, doi:10.1038/s41421-019-0121-y, Accepted Aug 8, Epub Sept 10 (2019).
    4. Hwen Zhu, Tianlong Zhang, Fang Wang, Jun Yang, and Jianping Ding* “Structural insights into the activation of USP46 by WDR48 and WDR20”, Cell Disc., 5:34 (2019).
    5. Yabing Liu$, Lejia Hu, Tengfei Ma$, Jun Yang, and Jianping Ding* “Insights into the inhibitory mechanisms of NADH on the ag heterodimer of human NAD-dependent isocitrate dehydrogenase”, Sci. Rep., 8:3146 (2018). ($Contributed equally)
    6. Shicheng Zhang, Linlin Wang, Ye Tao, Tuya Bai, Rong Lu, Tianlong Zhang, Jiangye Chen, and Jianping Ding*Structural basis for the functional role of the Shu complex in homologous recombination”, Nucleic Acids Res., 45: 13068-13079 (2017).
    7. Tianlong Zhang$, Rong Wang$, Zhijing Wang, Xiangxiang Wang, Fang Wang, and Jianping Ding* “Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1”, Nature Comm., 8: 1394 (2017). ($Contributed equally)
    8. Chen Zhong*, Jinlong Shen, Huibing Zhang, Guangyi Li, Senlin Shen, Fang Wang, Kuan Hu, Longxing Cao, Yongning He, and Jianping Ding* “Cbln1 and Cbln4 are structurally similar but differ in GluD2 binding interactions”, Cell Rep., 20: 2328-2340 (2017).
    9. Chen Zhong, Rongfen Huo, Kuan Hu, Jinlong Shen, Dangsheng Li, Ningli Li, and Jianping Ding* “Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9”, J. Mol. Recognit., 30: e2645 (2017).
    10. Ye Tao$, Chen Zhong$, Junjun Zhu, Shutong Xu, and Jianping Ding* “Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2”, Nucleic Acids Res., 45: 5707-5719 (2017). ($Contributed equally)
    11. Tengfei Ma, Yingjie Peng, Wei Huang, Yabing Liu, and Jianping Ding* “The b and g subunits play distinct functional roles in the a2bg heterotetramer of human NAD-dependent isocitrate dehydrogenase”, Sci. Rep., 7: 41882 (2017).
    12. Tengfei Ma, Yingjie Peng, Wei Huang, and Jianping Ding* “Molecular mechanism of the allosteric regulation of the ag heterodimer of human NAD-dependent isocitrate dehydrogenase”, Sci. Rep., 7: 40921 (2017).
    13. Wenshuai Wang$, Xiaoyu Sun$, Yanbing Li$, Jinpeng Su$, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen*, Jianping Ding*, and Bing Sun* “Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses”, Nature Comm., 7: 13577 (2016). ($Contributed equally)
    14. Jing Xia$, Rong Wang$, Tianlong Zhang*, and Jianping Ding* “Structural insight into the arginine binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling”, Cell Disc., 2: 16035 (2016). ($Contributed equally)
    15. Rong Wang, Zhijing Wang, Tianlong Zhang*, and Jianping Ding* “Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1”, J. Mol. Cell Biol., 8: 459-461 (2016).
    16. Fengjuan Lv, Tianlong Zhang, Zhen Zhou, Shuaixin Gao, Catherine CL Wong, Jin-Qiu Zhou, and Jianping Ding* “Structural basis for Sfm1 functioning as a protein arginine methyltransferase”, Cell Disc., 1: 15037 (2015).
    17. Wenjing Li, Tianlong Zhang, and Jianping Ding* “Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi”, Nucleic Acids Res., 43: 10026-10038 (2015).
    18. Shaoqiong Xu$, Tianlong Zhang$, Shiva N. Kompella$, Mengdi Yan, Aiping Lu, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, David J. Adams*, Jianping Ding*, and Chunguang Wang* “Conotoxin aD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors”, Sci. Rep., 5: 14261 (2015). ($Contributed equally)
    19. Qingyu Tang, Caifeng Liu, Chen Zhong, and Jianping Ding* “Crystal structures of Arabidopsis thaliana Nudix hydrolase NUDT7 reveal a previously unobserved conformation”, Mol. Plant, 8: 1557-1559 (2015).
    20. Katie Powis$, Tianlong Zhang$, Nicolas Panchaud, Rong Wang, Claudio De Virgilio*, and Jianping Ding* “Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling”, Cell Res., 25: 1043-1059 (2015). ($Contributed equally)
    21. Lun Zhang, Jianchuan Wang, Li Hou, Pengrong Cao, Li Wu, Qiansen Zhang, Huaiyu Yang, Yi Zhang*, Jianping Ding* and Jia Li* “Functional role of histidine in the conserved His-x-Asp motif in the catalytic core of protein kinases”, Sci. Rep., 5: 10115 (2015).
    22. Fang Yu$, Fangyuan He$, Hongyan Yao, Chengyuan Wang, Jianchuan Wang, Jianxu Li, Xiaofeng Qi, Hong-Wei Xue*, Jianping Ding*, and Peng Zhang* “Structural basis of intramitochondrial phosphatidic acid transport mediated by the Ups1-Mdm35 complex”, EMBO Rep., 16: 813-823 (2015). ($Contributed equally)
    获奖及荣誉:
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    研究组成员:
  • 合影