1995年毕业于武汉大学，获学士学位;2001年毕业于中科院上海生化所，获博士学位。2001年11月至2012年1月于美国德州大学西南医学中心从事博士后研究。2012年2月起，在中科院上海生物化学与细胞生物学研究所任研究员，研究组长。

　　当病原体入侵高等有机体时，会引发免疫反应，包括天然免疫和适应性免疫。天然免疫反应起始于宿主细胞的受体分子对病原体上的特异分子或者其它“异己”成分的识别，随后激活特定的信号通路，诱导相应基因表达,防御病原体侵染。譬如当病毒感染细胞时，病毒相关的核酸分子会被细胞内的受体分子识别而激活相应的信号通路，诱导抗病毒的干扰素产生。天然免疫反应能够为有机体提供及时的保护，但是其信号异常也可能导致自身免疫疾病等后果。肿瘤发生过程中产生的危险信号分子也可以激活天然免疫反应，诱导炎症。我们近期聚焦RIG-I-MAVS信号通路，利用生物化学和分子生物学方法在细胞和动物水平上来解析其中的分子细胞机制，研究该信号通路与自身免疫疾病发生的相关性及其在肿瘤治疗中的功能作用。

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