2009年毕业于美国康涅狄格大学医学院获生物医学博士学位，同时获商学院工商管理学硕士学位。同年5月作为独立PI获得Connecticut Stem Cell Seed Award研究经费资助，受聘于康涅狄格大学干细胞学院从事博士后研究，并于2010年5月任助理教授。2011年1月回国任中国科学院生物化学与细胞生物学研究所研究员，从事核糖核酸生物学研究。迄今，发表学术论文百余篇，其中通讯作者论文90余篇，包括发表在Cell、Nature、Science期刊12篇（含4篇综述/展望）及其子刊20余篇。Google Scholar引用超3.7万次。获选首批新基石研究员、HHMI国际研究员、国际RNA学会科研中期成就奖、FAOBMB卓越研究奖、中国青年科技奖特别奖、科学探索奖、谈家桢生命科学创新奖等学术奖励。“环形RNA生成和功能机制的研究”获国家自然科学奖二等奖（第一完成人）。目前担任核糖核酸功能与应用全国重点实验室主任、中国生物物理学会副理事长、中国生物化学与分子生物学会基因专业分会主任。自2020年起，同时担任Science、Cell、Molecular Cell等期刊的科学顾问或编委。

　　近年来的研究表明长非编码RNAs和环形RNAs广泛参与一系列细胞的重要功能调控，包括细胞核亚结构的形成、基因表达的遗传与表观遗传调控等。我们实验室主要研究哺乳动物细胞中这些具有调控功能的RNAs，包括新类型分子发现、其加工成熟机制、其在转录、染色体、细胞核亚结构和干细胞干性维持等方面的功能、以及相关应用潜能。主要研究内容如下：

　　1、通过转录组测序和计算生物学手段结合的方法，发掘和鉴定人类基因组中的新类型RNA分子

　　2、利用分子生物学、细胞生物学和生物化学的手段，研究RNA分子在基因表达调控中的作用机制及应用

　　3、采用基因组编辑和活细胞成像等手段，研究RNA在细胞核亚结构和染色体维持和调控过程中的功能

　　4、以干细胞多能性维持和分化为模型，研究RNA对干细胞的命运决定的调控

　　研究成果将能够丰富我们对长非编码RNAs和环形RNAs功能和机制的认识，拓展不同类型RNA的应用潜能，并为全面认识细胞命运可塑性提供一个全新水平的调控。

　　我们实验室在充分尊重和鼓励个人兴趣爱好的前提下，致力于为学生和博士后提供全面的指导，培养科学探索精神和职业道德，共同营造一个具有归属感、成就感的环境，使我们做出最好、最有创新性的工作。在此我们真诚欢迎对科学研究抱有热情和理想的你来报考博士生、硕士生，并真诚欢迎博士后加入。

1. Pan YH^#, Shan L^#, Zhang YY^#, Yang ZH, Zhang Y, Cao SM, Liu XQ, Zhang J, Yang L and Chen LL*. 2025. Pre-rRNA spatial distribution and functional organization of the nucleolus. Nature, 646(8083):227-235.
2. Liu XQ^#, Li Pan^#, Gao BQ^#, Zhu HL, Yang LZ, Wang Y, Zhang YY, Wu H, Pan YH, Shan L, Yu HT, Yang L and Chen LL*. 2025. De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses. Cell, 188(17):4586-4603.
3. Feng X^#, Jiang BW^#, Zhai SN, Liu CX, Wu H, Zu BQ, Wei MY, Wei J, Yang L and Chen LL*. 2025. Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models. Nat Biotechnol, AOP Mar 31^th.
4. Tao X^#, Zhai SN^#, Liu CX^#, Huang YK, Wei J, Guo YL, Liu XQ, Li X, Yang L* and Chen LL*. 2025. Degradation of circular RNA by the ribonuclease DIS3. Mol Cell, 85(8):1674-1685.
5. Guo SK^#, Liu CX^#, Xu YF^#, Wang X^#, Nan F^#, Huang YK, Li SQ, Nan S, Li L, Kon E, Li C, Wei MY, Su R, Wei J, Peng SG, Ad-El N, Liu JQ, Peer D, Chen T, Yang L and Chen LL*. 2025. Therapeutic application of circular RNA aptamers in a mouse model of psoriasis. Nat Biotechnol, 43(2):236-246.
6. Chen LL* and Kim VN*. 2024. Small and long non-coding RNAs: past, present, and future. Cell, 187(23):6451-6485.
7. Chen LL*. 2024. Linking a neurodevelopmental disorder with a lncRNA deletion. New Engl J Med, 391(16):1542-1545.
8. Liu CX, Yang L and Chen LL*. 2024. Dynamic conformation: marching toward circular RNA function and application. Mol Cell, 84(19):3596-3609.
9. Shan L and Chen LL*. 2024. Unveiling the mystery of nuclear RNA homeostasis. Cell Stem Cell, 31(5):583-585.
10. Cao SM^#, Wu H^#, Yuan GH^#, Pan YH, Zhang J, Liu YX, Li SQ, Xu YF, Wei MY, Yang L and Chen LL*. 2024. Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function. Mol Cell, 84(12):2304-2319.
11. Yang LZ^#, Min YH^#, Liu YX^#, Gao BQ, Liu XQ, Huang YK, Wang HF, Yang L, Liu Z and Chen LL*. 2024. CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells. Nat Methods, 21(9):1646-1657.
12. Shan L^#, Li P^#, Yu HT* and Chen LL*. 2023. Emerging roles of nuclear bodies in genome spatial organization. Trends Cell Biol, 34(7):595-605.
13. Shan L^#, Xu G^#, Yao RW, Luan PF, Huang YK, Zhang PH, Pan YH, Zhang L, Gao X, Li Y, Cao SM, Gao SX, Yang ZH, Li SQ, Yang LZ, Wang Y, Wong CCL, Yu L, Li JS, Yang L and Chen LL*. 2023. Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature, 615(7952):526-534.
14. Chen LL*, Bindereif A, Bozzoni I, Chang HY, Matera GA, Gorospe M, Hansen TB, Kjems J, Ma XK, Pek JW, Rajewsky N, Salzman J, Wilusz JE*, Yang L* and Zhao F. 2023. A guide to naming eukaryotic circular RNAs. Nat Cell Biol, 25(1):1-5.
15. Chen LL*. 2022. Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function. Nat Methods, 19(10):1152-1155.
16. Liu CX and Chen LL*. 2022. Circular RNAs: characterization, cellular roles, and applications. Cell, 185(12):2016-2034.
17. Yang L^*, Wilusz JE^* and Chen LL*. 2022. Biogenesis and regulatory roles of circular RNAs. Annu Rev Cell Dev Biol, 38:263-289.
18. Liu CX^#, Guo SK^#, Nan F, Xu YF, Yang L and Chen LL*. 2022. RNA circles with minimized immunogenicity as potent PKR inhibitors. Mol Cell, 82(2):420-434.
19. Liu CX and Chen LL*. 2021. Expanded regulation of circular RNA translation. Mol Cell, 81(20):4111-4113.
20. Wu M^#, Xu G^#, Han C^#, Luan PF, Xing YH, Nan F, Yang LZ, Huang YK, Yang ZH, Shan L, Yang L, Liu JQ* and Chen LL*. 2021. lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription. Science, 373(6554):547-555.
21. Statello L^#, Guo CJ^#, Chen LL* and Huarte M*. 2021. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol, 22(2):96-118.
22. Li SQ^#, Li X^#, Xue W^#, Zhang L^#, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li J^*, Yang L^* and Chen LL*. 2021. Screening for functional circular RNAs using the CRISPR-Cas13 system. Nat Methods, 18(1):51-59.
23. Guo CJ, Xu G and Chen LL*. 2020. Mechanisms of long noncoding RNA nuclear retention. Trends Biochem Sci, 45(11):947-960.
24. Chen LL*. 2020. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol, 21(8):475-490.
25. Guo CJ^#, Ma XK^#, Xing YH, Zheng CC, Xu YF, Shan L, Zhang J, Wang SH, Wang YM, Carmichael GG, Yang L and Chen LL*. 2020. Distinct processing of lncRNAs contributes to non-conserved functions in stem cells. Cell, 181(3):621-636.
26. Yang LZ^#, Wang Y^#, Li SQ, Yao RW, Luan PF, Wu H, Carmichael GG and Chen LL*. 2019. Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems. Mol Cell, 76(6):981-997.
27. Yao RW^#, Xu G^#, Wang Y, Shan L, Luan PF, Wang Y, Wu M, Yang LZ, Xing YH, Yang L and Chen LL*. 2019. Nascent pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus. Mol Cell, 76(5):767-783.
28. Liu CX^#, Li X^#, Nan F^#, Jiang S, Gao X, Guo SK, Xue W, Cui YG, Dong KG, Ding HH, Qu B, Zhou ZC, Shen N^*, Yang L^* and Chen LL*. 2019. Structure and degradation of circular RNAs regulate PKR activation in innate immunity. Cell, 177(4):865-880.
29. Yao RW^#, Wang Y^# and Chen LL*. 2019. Cellular functions of long noncoding RNAs. Nat Cell Biol, 21(5):542-551.
30. Wang Y^#, Hu SB^#, Wang MR^#, Yao RW, Wu D, Yang L and Chen LL*. 2018. Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria. Nat Cell Biol, 20(10):1145-1158.
31. Li X, Yang L* and Chen LL*. 2018. The biogenesis, functions, and challenges of circular RNAs. Mol Cell, 71(3):428-442.
32. Xiang JF^#, Yang Q^#, Liu CX^#, Wu M, Chen LL* and Yang L*. 2018. N⁶-methyladenosines modulate A-to-I RNA editing. Mol Cell, 69(1):126-135.
33. Li X^#, Liu CX^#, Xue W^#, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L* and Chen LL*. 2017. Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection. Mol Cell, 67(2):214-227.
34. Xing YH^#, Yao RW^#, Zhang Y^#, Guo CJ, Jiang S, Xu G, Dong R, Yang L and Chen LL*. 2017. SLERT regulates DDX21 rings associated with Pol I transcription. Cell, 169(4):664-678.
35. Yang L* and Chen LL*. 2017. Enhancing the RNA engineering toolkit. Science, 358(6366):996-997.  
36. Wu H, Yang L* and Chen LL*. 2017. The diversity of long noncoding RNAs and their generation. Trends Genet, 33(8):540-552.
37. Chen LL* and Yang L*. 2017. AlUternative regulation for gene expression. Trends Cell Biol, 27(7):480-490.
38. Wu H^#, Yin QF^#, Luo Z^#, Yao RW, Zheng CC, Zhang J, Xiang JF, Yang L and Chen LL*. 2016. Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins. Mol Cell, 64(3):534-548.
39. Chen LL*. 2016. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol, 17(4):205-211.
40. Chen LL*. 2016. Linking long noncoding RNA localization and function. Trends Biochem Sci, 41(9):761-772.
41. Chen LL* and Yang L*. 2015. Gear up in circles. Mol Cell, 58(5):715-717.
42. Zhang XO^#, Wang HB^#, Zhang Y, Lu XH, Chen LL* and Yang L*. 2014. Complementary sequence-mediated exon circularization. Cell, 159(1):134-147.
43. Yang L* and Chen LL*. 2014. Microexons go big. Cell, 159(7):1488-1489.
44. Zhang Y^#, Zhang XO^#, Chen T, Xiang JF, Yin QF, Xing YH, Zhu SS, Yang L* and Chen LL*. 2013. Circular intronic long noncoding RNAs. Mol Cell, 51(6):792-806.
45. Yin QF^#, Yang L^#, Zhang Y, Xiang JF, Wu YW, Carmichael GG* and Chen LL*. 2012. Long noncoding RNAs with snoRNA ends. Mol Cell, 48(2):219-230.
46. Yang L, Duff MO, Graveley BR, Carmichael GG and Chen LL*. 2011. Genomewide characterization of non-polyadenylated RNAs. Genome Biol, 12(2):R16.

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