个人简介:
2004年毕业于中科院生物化学与细胞生物学研究所,获理学博士学位。2004年赴美国哈佛大学医学院Dana-Farber肿瘤研究所从事免疫学研究,先后为博士后(受美国关节炎基金会资助),instructor。2009年11月回生化与细胞所工作,担任研究员与研究组长,现任所长助理、分子生物学国家重点实验室副主任、中国生物化学与分子生物学会副秘书长。先后入选国家杰出青年基金、科技部中青年科技创新领军人才、上海市科委优秀学术带头人计划;成果入选中国科学十大进展和中国生命科学十大进展;获谈家桢生命科学奖创新奖、中源协和生命医学奖、全国优秀科技工作者、上海青年科技英才等奖项。
代表论著:
( #first author, *corresponding author )
- Guo J, Xu C*, Screening for the next-generation T cell therapies. Cancer Cell, 37(5): 627-629, 2020.
- Fan Z#, Tian Y#, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P*, Ding K*, Chen L*, Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO molecular medicine, e11571, 2020.
- He X, Xu C*, PD-1: A Driver or Passenger of T Cell Exhaustion? Molecular Cell, 77(5): 930-931, 2020.
- Huang B, Song B, Xu C*. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nature Metabolism, 2: 132-141, 2020.
- Xu X#, Li H#, Xu, C*. Structural understanding of T cell receptor triggering. Cellular & Molecular Immunology, 17(3): 193-202, 2020.
- Li H*, Yan C, Guo J, Xu C*. Ionic protein–lipid interactions at the plasma membrane regulate the structure and function of immunoreceptors. Advances in Immunology, 144 pp 65-85, 2019.
- Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez R, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold B, Zhu C, Chen W*, Lou J*. Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Molecular Cell. 73(5):1015-1027, 2019.
- Meng X#, Liu X#, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu X, Zhou P, Huang X, Wei L, Yang W, Xu C*. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 564 (7734): 130-135, 2018.
- Guo J#, Zhang Y#, Li H#, Chu H#, Wang Q, Jiang S, Li Y, Shen H, Li G*, Chen J*, Xu C*. Intramembrane ionic protein-lipid interaction regulates integrin structure and function. PLoS Biology, 16(11):e2006525, 2018.
- Chen X#, Sun X#, Yang W#, Yang B#, Zhao X, Chen S, He L, Chen H, Yang C, Xiao L, Chang Z, Guo J, He J, Zhang F, Zheng F, Hu Z, Yang Z, Lou J, Zheng W, Qi H, Xu C, Zhang H, Shan H, Zhou XJ, Wang Q, Shi Y, Lai L, Li Z*, Liu W*. An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. Science. 362 (6415): 700-705, 2018.
- Wang J, Yan C, Xu C, Chua B, Li P*, Chen F*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. Journal of Biological Chemistry. 293(50):19330-19343, 2018.
- Xu C, Xie H, Guo X, Gong H, Liu L, Qi H, Xu C, Liu W*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology, 2(17), 2017
- Bietz A#, Zhu H#, Xue M, Xu C*. Cholesterol Metabolism in T Cells. Frontiers in Immunology, 8:1664, 2017
- Yang W#, Pan W#, Chen S#, Trendel N#, Jiang S#, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O*, Li H*, Xu C*. Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nature Structural & Molecular Biology, 24(12), pp 1081-1092, 2017.
- Wang H, Wang S, Li C, Li H, Mao Y, Liu W, Xu C*, Long D*. Probing Transient Release of Membrane-Sequestered Tyrosine-Based Signaling Motif by Solution NMR Spectroscopy. The Journal of Physical Chemistry Letters, 8(16), pp 3765-3769, 2017.
- Li L#, Guo X#, Shi X#, Li C#, Wu W, Yan C, Wang H, Li H, Xu C*. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proceedings of the National Academy of Sciences of the United States of America (Plus), 114(29), pp E5891-E5899, 2017.
- Guo X#, Yan C#, Li H#, Huang W#, Shi X, Huang M, Wang Y, Pan W, Cai M, Li L, Wu W, Bai Y, Zhang C, Liu Z, Wang X, Zhang F X, Tang C, Wang H, Liu W, Ouyang B, Catherine C Wong, Cao Y*, Xu C*. Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Research, 27(4), pp 505-525, 2017.
- Xu L#, Xia M#, Guo J#, Sun X#, Li H, Xu C, Gu X, Zhang H, Yi J, Fang Y, Xie H, Wang J, Shen Z, Xue B, Sun Y, Meckel T, Chen Y, Hu Z, Li Z*, Xu C*, Gong H*, Liu W*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. The Journal of Experimental Medicine, 213(12), pp 2707-2727, 2016.
- Wu W, Shi X, Xu C*. Regulation of T cell signalling by membrane lipids. Nature Reviews Immunology, 16(11), pp 690-701, 2016.
- Liu W*, Wang H, Xu C*. Antigen Receptor Nanoclusters:Small Units with Big Functions. Trends in Immunology, 37(10), pp 680-689, 2016.
- Yang W#, Bai Y#, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang C, Chang T, Zhang T, Zhou P Song B, Liu W, Sun S, Liu X, Li B*, Xu C*. Potentiating the anti tumour response of CD8+ T cells by modulating cholesterol metabolism. Nature, 531(7596), pp 651-655, 2016.
- Cui Y#, Chen X#, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X*. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. Cell Reports, 15(2), pp 256-263, 2016.
- Chen X#, Pan W#, Sui Y, Li H, Shi X, Guo X, Qi H, Xu C*, Liu W*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications, 6(8552), 2015.
- Liu C#, Zhao X#, Xu L, Yi J, Shaheen S, Han W, Wang F, Zheng W, Xu C, Liu W. A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse. Journal of Leukocyte Biology, 97(5), pp 887-900, 2015.
- Wu W#, Yan C#, Shi X, Li L, Liu W, Xu C*. Lipid in T-cell receptor transmembrane signaling. Progress in Biophysics and Molecular Biology, 118(3), pp 130-138, 2015.
- Wang Y#, Gao J#, Guo X#, Tong T, Shi X, Li L, Qi M, Wang Y, Cai M, Jiang J, Xu C*, Ji H*, Wang H*. Regulation of EGFR nanocluster formation by ionic protein-lipid interaction. Cell Research, 24(8), pp 959-976, 2014.
- Li L#, Shi X#, Guo X, Li H, Xu C*. Ionic protein-lipid interaction at the plasma membrane: what can the charge do? Trends in Biochemical Sciences, 39(3), pp 130-140, 2014.
- Wertek F, Xu C*. Digital response in T cells: to be or not to be. Cell Research, 24(3), pp 265-266, 2014.
- Li P, Fu Z, Zhang Y, Zhang J, Xu C, Ma Y, Li B, Song B. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nature Medicine, 20(1), pp 80-86, 2014.
- Shi X#, Bi Y#, Yang W#, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J*, Xu C*. Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids. Nature, 493(7430), pp 111-115, 2013.
- Liu B#, Liu Y#, Du Y, Mardaryev A, Yang W, Chen H, Xu Z, Xu C, Zhang X, Botchkarev V, Zhang Y*, Xu G*. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development, 140(4), pp 780-788, 2013.
- Zhang K#, Pan Y#, Qi J, Yue J, Zhang M, Xu C, Li G*, Chen J*. Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7. Journal of Cell Science, 126(Pt21), pp 5030-5041, 2013.
- Wang X#, Jimenez-Vargas J#, Xu C, Possani L*, Zhu S*. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins. Biochemical and Biophysical Research Communications, 429(1-2), pp 111-116, 2012.
- Gagnon E, Xu C, Yang W, Chu H, Call M, Chou J, Wucherpfennig K*. Response multilayered control of T cell receptor phosphorylation. Cell, 142(5), pp 669-671, 2010.
- Xu C#, Gagnon E#, Call M, Schnell J, Schwieters C, Carman C, Chou J*, Wucherpfennig K*. Regulation of T cell Receptor Activation by Dynamic Membrane Binding of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell, 135(4), pp 702-713, 2008.
- Wang S, Huang L, Wicher D, Chi C*, Xu C*. Structure-function relationship of bifunctional scorpion toxin BmBKTx1. Acta Biochimica et Biophysica Sinica (Shanghai), 40(11), pp 955-963, 2008.
- O’Connor K#, McLaughlin KA#, De Jager P, Chitnis T, Bettelli E, Xu C, Robinson W, Cherry S, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong S, Tavakoli N, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale R, Freedman M, Steinman L, Buckle G, Kuchroo V, Hafler D*, Wucherpfennig K*. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine, 13(2), pp 211-217, 2007.
- Xu C, Call M, Wucherpfennig K. A membrane-proximal tetracysteine motif contributes to assembly of cd3de and cd3ge dimers with the T cell receptor. Journal of Biological Chemistry, 281(48), pp 36977-36984, 2006.
- Call M#, Schnell J#, Xu C, Lutz R, Chou J*, Wucherpfennig K*. The Structure of the ζζ Transmembrane Dimer Reveals Polar Features Essential for Dimerization and Assembly with the T cell Receptor. Cell, 127(2), pp 355-368, 2006.
- Jiang H, Xu C, Wang C, Fan C, Zhao T, Chen J, Chi C. Two novel O-superfamily conotoxins from Conus vexillum. Toxicon, 47(4), pp 425-436, 2006.
- Jiang H#, Wang C#, Xu C, Fan C, Dai X, Chen J, Chi C. A novel M-superfamily conotoxin with a unique motif from Conus vexillum. Peptides, 27(4), pp 682-689, 2006.
- Xu C#, Br?ne B#, Wicher D, Bozkurt O, Lu W, Huys I, Han Y, Tytgat J, Van Kerkhove E, Chi C. BmBKTx1, a novel Ca2+activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. Journal of Biological Chemistry, 279(33), pp 34562-34569, 2004.
- Xu C, He L, Br?ne B, Martin-Eauclaire M, Van Kerkhove E, Zhou Z, Chi C. A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon, 43(8), pp 961-971, 2004.
- Cai Z#, Xu C#, Xu Y, Lu W, Chi C, Shi Y, Wu J. Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry, 43(13), pp 3764-3771, 2004.
- Huys I#, Xu C#, Wang C, Vacher H, Martin-Eauclaire M, Chi C, Tytgat J. BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochemical Journal, 378(3), pp 45-52, 2004.
- Frénal K#, Xu C#, Wolff N, Wecker K, Gurrola G, Zhu S, Chi C, Possani L, Tytgat J*, Delepierre M*. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. PROTEINS: Structure, Function, and Bioinformatics, 56(2), pp 367-375, 2004.
- Szyk A, Lu W, Xu C, Lubkowski J. Structure of the Scorpion Toxin BmBKTx1 Solved from Single Wavelength Anomalous Scattering of Sulfur. Journal of Structural Biology, 145(3), pp 289-294, 2004.
- Xu C, Zhu S, Chi C, Tytgat J. Turret and pore block of K+ channels: what is the difference? Trends in Pharmacological Sciences, 24(9), pp 446-448, 2003.