2001年毕业于山东大学，获学士学位;2006年毕业于中科院生化与细胞所，获博士学位。2006年12月至2012年7月于美国哈佛医学院/以色列女执事医学中心(Harvard Medical School/Beth Israel Deaconess Medical Center)从事博士后研究。2012年7月底回国就任中国科学院生物化学与细胞生物学研究所研究员，研究组长。

肿瘤细胞的一个重要特征是近乎无限的分裂增殖。这种表型可能由多种生理过程的异常所引起，包括细胞周期负调因子的缺失突变、细胞代谢途径的超常活跃、关键信号通路的活化及细胞凋亡通路的异常等。本实验室的研究兴趣主要集中于调控肿瘤细胞生长增殖的核心信号转导与细胞代谢调节机制方面，特别是发现关键信号蛋白的重要翻译后修饰，从而诠释肿瘤细胞生长增殖/癌症发生发展的分子机制，并为癌症的临床治疗提供新的思路与治疗靶点。

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2. Gao, D., H. Inuzuka, M. Korenjak, A. Tseng, T. Wu, L. Wan, M. Kirschner, N. Dyson, and W. Wei*. "Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2f1 Pathways." Molecular Biology of the Cell , no. 14 (2009): 3305-16.
3. Gao, D., L. Wan, H. Inuzuka, A. H. Berg, A. Tseng, B. Zhai, S. Shaik, E. Bennett, A. E. Tron, J. A. Gasser, A. Lau, S. P. Gygi, J. W. Harper, J. A. DeCaprio, A. Toker, and W. Wei*. "Rictor Forms a Complex with Cullin-1 to Promote Sgk1 Ubiquitination and Destruction." Molecular Cell , no. 5 (2010): 797-808.
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6. Hu, H., W. Zhu, J. Qin, M. Chen, L. Gong, L. Li, X. Liu, Y. Tao, H. Yin, H. Zhou, L. Zhou, D. Ye, Q. Ye, and D. Gao.* "Acetylation of Pgk1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis." Hepatology , no. 2 (2017): 515-28.
7. Liu, X., M. Chen, L. Li, L. Gong, H. Zhou, and D. Gao.* "Extracellular Signal-Regulated Kinases (Erks) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation." Journal of Biological Chemistry , no. 10 (2017): 3970-76.
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9. Cui, B., L. Gong, M. Chen, Y. Zhang, H. Yuan, J. Qin, and D. Gao.* "Cul5-Socs6 Complex Regulates Mtorc2 Function by Targeting Sin1 for Degradation." Cell Discovery , no. 1 (2019).
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11. Kuai, X., L. Li, R. Chen, K. Wang, M. Chen, B. Cui, Y. Zhang, J. Li, H. Zhu, H. Zhou, J. Huang, J. Qin, Z. Wang, W. Wei, and D. Gao.* "Scffbxw7/Gsk3β-Mediated Gfi1 Degradation Suppresses Proliferation of Gastric Cancer Cells." Cancer Research , no. 17 (2019): 4387-98.
12. Gao, Q., H. Zhu, L. Dong, W. Shi, R. Chen, Z. Song, C. Huang, J. Li, X. Dong, Y. Zhou, Q. Liu, L. Ma, X. Wang, J. Zhou, Y. Liu, E. Boja, A. I. Robles, W. Ma, P. Wang, Y. Li, L. Ding, B. Wen, B. Zhang, H. Rodriguez, D. Gao,* H. Zhou,* and J. Fan*. "Integrated Proteogenomic Characterization of Hbv-Related Hepatocellular Carcinoma." Cell , no. 2 (2019): 561-77.e22.
13. Dong, L., D. Lu, R. Chen, Y. Lin, H. Zhu, Z. Zhang, S. Cai, P. Cui, G. Song, D. Rao, X. Yi, Y. Wu, N. Song, F. Liu, Y. Zou, S. Zhang, X. Zhang, X. Wang, S. Qiu, J. Zhou, S. Wang, X. Zhang, Y. Shi, D. Figeys, L. Ding, P. Wang, B. Zhang, H. Rodriguez, Q. Gao,* D. Gao,* H. Zhou,* and J. Fan.* "Proteogenomic Characterization Identifies Clinically Relevant Subgroups of Intrahepatic Cholangiocarcinoma." Cancer Cell, no. 1 (2022): 70-87.e15.
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15. Chen, M., K. Wang, Y. Han, S. Yan, H. Yuan, Q. Liu, L. Li, N. Li, H. Zhu, D. Lu, K. Wang, F. Liu, D. Luo, Y. Zhang, J. Jiang, D. Li, L. Zhang, H. Ji, H. Zhou, *Y. Chen, *J. Qin,* and D. Gao.* "Identification of Xaf1 as an Endogenous Akt Inhibitor." Cell Reports , no. 7 (2023).
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17. Gao, D., and G. Ge. "Exploring the Underlying Biology of Cancer and Potential Therapeutic Strategies: A Special Issue Focused on Mechanism-Based Studies." Acta Biochimica et Biophysica Sinica , no. 6 (2023): 891-92.
18. Liu, Q., J. Zhang, C. Guo, M. Wang, C. Wang, Y. Yan, L. Sun, D. Wang, L. Zhang, H. Yu, L. Hou, C. Wu, Y. Zhu, G. Jiang, H. Zhu, Y. Zhou, S. Fang, T. Zhang, L. Hu, J. Li, Y. Liu, H. Zhang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. Gao,* H. Ji,* H. Zhou,* and P. Zhang.* "Proteogenomic Characterization of Small Cell Lung Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies." Cell , no. 1 (2024): 184-203.e28.
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20. Wang, K., M. Chen, S. Yan, Y. Han, H. Yuan, Q. Liu, D. Lu, L. Li, K. Wang, F. Liu, Q. Li, D. Luo, J. Jiang, H. Zhou,* Y. Chen,* J. Qin,* and D. Gao.* "Zinc Ions Activate Akt and Promote Prostate Cancer Cell Proliferation Via Disrupting Akt Intramolecular Interaction." Oncogene , no. 1 (2025): 8-18.
21. Gao, D., and J. W. P. Yam. "Reversal of Lipid Metabolism as a Therapeutic Approach for Hcc." Hepatology , no. 4 (2025): 1113-15.
22. Chen, R., C. Ma, H. Qian, X. Xie, Y. Zhang, D. Lu, S. Hu, M. Zhang, F. Liu, Y. Zou, Q. Gao, H. Zhou, H. Liu, M. Lin,* G. Ge,* and D. Gao.* "Mutant Kras and Ck2 Cooperatively Stimulate Slc16a3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression." Cancer Research , no. 7 (2025): 1253-69.
23. Ji, S., L. Cao, J. Gao, Y. Du, Z. Ye, X. Lou, F. Liu, Y. Zhang, J. Xu, X. Shi, H. Wang, P. Li, Y. Li, H. Chen, Z. Yang, S. Gao, W. Zhang, D. Huang, S. Ni, M. Wei, F. Wang, Y. Wang, T. Ding, D. Jing, G. Fan, Z. Gong, R. Lu, Y. Qin, J. Chen, X. Xu, P. Wang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. K. Chang, R. H. Hruban, D. Gao, D.* Gao, G.* Jin, H.* Zhou,* J. Wu,* and X. Yu.* "Proteogenomic Characterization of Non-Functional Pancreatic Neuroendocrine Tumors Unravels Clinically Relevant Subgroups." Cancer Cell , no. 4 (2025): 776-96.e14.