陈江野--中国科学院分子细胞科学卓越创新中心

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陈江野
研究员，研究组长，博士生导师
E-mail: jychen@@sibcb.ac.cn
实验室主页:

个人简介：

　　国家杰出青年基金获得者，1988年中科院上海生物化学研究所研究生毕业，获博士学位。1990-1992年赴美国加州大学欧文分校做博士后。1995年任中科院上海生化所研究员、博士生导师，1999年任中科院上海生科院生化细胞所研究员、博士生导师。曾获中国科学院自然科学奖二等奖、上海市三八红旗手、优秀回国人员等称号，荣获国务院特殊津贴。曾任中华全国青联委员,上海遗传学会常务理事，中国遗传学会理事。现任中国生物化学与分子生物学会理事、基因专业委员会主任。上海市学科带头人计划、863计划、基金委重点项目等多种科研项目资助。现任中科院上海生命科学研究院生物化学与细胞生物学研究所研究员，博士生导师，研究组组长。

社会任职：

研究方向：

形态发生的基因表达调控与表观遗传调控

研究工作：

　　主要从事形态发生基因表达调控与表观遗传调控的研究。在基因水平、染色质水平和细胞水平研究白念珠菌形态发生的调控机制。包括白念珠菌形态转变和致病相关因子的鉴定与功能研究，信号转导途径在白念珠菌形态发生和致病过程中的调控机制，转录因子、染色质修饰复合物和染色质重塑复合物在白念珠菌菌丝发育和白灰形态转换过程的功能作用,白念珠菌与宿主细胞的相互作用以及在白念珠菌感染过程宿主细胞的免疫应答调控网络研究。在学术期刊上发表了60余篇研究论文，获得授权发明专利10多项，申报发明专利多项。

承担科研项目情况：

代表论著：

1. Minghui Yan, Xinyi Nie, Huafeng Wang, Ning Gao, Haoping Liu and Jiangye Chen*, Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in Candida albicans. Mol Microbiol. 2015 Jun 25. doi: 10.1111.
2. Peng Chang, Xueyi Fan and Jiangye Chen*, Function and subcellular localization of Gcn5, a histone acetyltransferase in Candida albicans. Fungal Genet Biol. 2015 Feb 3. doi: 10.1016.
3. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*, Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6): 642-52.
4. Shicheng Zhang, Tianlong Zhang, Minghui Yan, Jianping Ding* and Jiangye Chen*, Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. Cell Res. 2014; 24(9):1108-20.
5. Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding* Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. Elife. 2014; 3. doi: 10.7554/eLife.02687.
6. Zhe Zhang, Shanshan Wang, Tong Shen, Jiangye Chen, and Jianping Ding,*Crystal Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2. Structure. 2014; 22(10): 1408-20.
7. Shan Li, Wei Song, Mei Jiang, Liyong Zeng, Xueliang Zhu, Jiangye Chen*, Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Letters, 2014; 588 (11): 1989-96.
8. Xiongjun Wang, Peng Chang, Jianping Ding and Jiangye Chen*, Distinct and Redundant Roles of the Two MYST Histone Acetyltransferases Esa1 and Sas2 in Cell Growth and Morphogenesis of Candida albicans. Eukaryot. Cell, 2013; 12 (3): 438-449.
9. Wenji Song, HuafengWang and Jiangye Chen*, Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model. FEMS Yeast Res, 2011, 11(2): 209-22.
10. HuafengWang, Wenji Song, Guanghua Huang, Zhou Zhou, Yufeng Ding and Jiangye Chen*, Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state. FEBS Letters, 2011, 585, 797–802.
11. Xinyi Nie, Xiaoyan Liu, HuafengWang and Jiangye Chen*, Deletion of EFG1 promotes Candida albicans opaque formation responding to pH via Rim101. Acta Biochim Biophys Sin, 2010, 42, 735-744.
12. Chang Su, Yandong Li, Yang Lu and Jiangye Chen*, Mss11, a Transcriptional Activator, is Required for Hyphal Development in Candida albicans. Eukaryot. Cell, 2009, 8 (11): 1780-1791.
13. Mei Jiang, Yankun Gao, Tao Yang, Xueliang Zhu, Jiangye Chen*, Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Letters, 2009, 583, 2171–2178.
14. Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu, and Jiangye Chen*. Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Mol. Biol. Cell. 2008, 19(10): 4260-4272.
15. Xuming Mao, Yandong Li, Huafeng Wang, Fang Cao, Jiangye Chen*. Antagonistic Interplay of Swi1 and Tup1 on Filamentous Growth of Candida albicans. FEMS Microbiol Lett, 2008, 285: 233-241.
16. Yandong Li, Chang Su, Xuming Mao, Fang Cao, and Jiangye Chen*. Roles of Candida albicans Sfl1 in Hyphal Development. Eukaryot. Cell, 2007, 6: 2112-2121.
17. Xuming Mao, Fang Cao, Xinyi Nie, Haoping Liu, Jiangye Chen*. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans. FEBS Letters, 2006, 580, 2615-2622.
18. Yan-kun Gao, Mei Jiang, Tao Yang, Jiangye Chen*. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res., 2006, 16, 539-547.
19. Fang Cao, Shelley Lane, Prashna Pala Raniga, Yang Lu, Zhou Zhou, Karalyn Ramon, Jiangye Chen*, Haoping Liu*. The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans. Mol Biol Cell. 2006; 17(1):295-307.
20. Guanghua Huang, Huafeng Wang, Song Chou, Xinyi Nie, Jiangye Chen*, and Haoping Liu*. Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci USA. 2006, 103, 12813-12818.

获奖及荣誉：

研究组成员：

合影