2001年获武汉大学学士学位，2007年获中科院上海生科院健康科学研究所博士学位，2008至2013年在美国安德森癌症中心(MD Anderson Cancer Center)做博士后研究，并成为奥德赛学者(Odyssey Fellow)。2013年8月起担任中科院生物化学与细胞生物学研究所研究员，研究组长，博士生导师。

肿瘤细胞的代谢重塑在肿瘤发生发展中发挥至关重要的作用。肿瘤细胞响应功能基因突变和多变的环境因素，如营养物、生长因子、免疫细胞和饮食等，主动调节代谢途径的通量、甚至改变特定途径的走向，以满足肿瘤细胞无限增殖所需的生物大分子合成原料、能量以及氧化还原稳态。此外，特定功能基因的突变还会导致一些有活性的代谢中间产物异常累积，进而通过调控基因的表达和信号转导的激活加速肿瘤生长，并促进肿瘤转移和治疗抵抗。只有充分解析这些过程才能发现肿瘤代谢重塑的关键节点，并转化为新型癌症治疗手段。

1. 肿瘤细胞的代谢重塑

2. 肿瘤免疫微环境的代谢调控

3. 代谢物丰度感知

（*Corresponding author）

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