1965-1969和1978-1981两次中国科学院上海生物化学研究所研究生毕业。1986年任生化所副研究员，1993年任研究员，博士生导师。长期以氨基酰-tRNA合成酶及其相关tRNA为对象研究酶与核酸的相互作用，以期加深人们对蛋白质生物合成质量控制机理的理解。曾获得国家自然科学二等奖，上海市自然科学一等奖、二等奖，何梁何利科技进步奖，七次中国科学院研究生导师奖，为全国劳动模范。《生命科学》和《生命的化学》副主编,《生物化学与生物物理学报》、《中国生物化学与分子生物学杂志》。EMBO J、Nucleic Acids Research、J. Biol. Chem.和Scientific Reports等杂志的审稿人。为中国科学院院士(2005年)、第三世界科学院(TWAS)院士(2006年)和中国医学科学院学部委员(2019年)。

　　长期从事生物化学与分子生物学研究。目前主要以tRNA和相关氨基酰-tRNA合成酶为对象核酸与酶的相互作用研究。氨基酰-tRNA合成酶是蛋白质生物合成过程中的关键酶，它催化蛋白质生物合成过程中的第一步反应-tRNA氨基酰化反应。氨基酰-tRNA合成酶对tRNA的精确识别保证了遗传信息由核酸传递到蛋白质的精确性，所以研究tRNA与氨基酰-tRNA合成酶的相互作用具有重要的生物学意义。随着研究的深入，该项研究还可以为人类的疾病防止和治疗、改善人类生存环境提供理论依据和新的思路。

　　研究组已发表研究论文120余篇。研究结果2400余次被包括《生物化学年鉴》和《细胞》中的综述，《美国科学院院报》，《欧洲分子生物学组织杂志》和《分子细胞》等学术刊物的研究论文引用。研究组与法国，加拿大，美国等多家实验室有合作研究关系。

1. Peng GX, Zhang Y, Wang QQ, Li QR, Xu H, En-Duo Wang* and Zhou XL*. The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases，Nucleic Acids Research, 2021, 49(5), 2816–2834.
2. Hao GY, Li H, Yang F, Dong DL, Li ZZ, Ding YY, Pan W, En-Duo Wang*, Liu RJ*, Zhou HC^*(2021) Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors，Bioorg. Med. Chem., 2021, 29, 115871.
3. Li G，Eriani G, En-Duo Wang* and Zhou XL* . Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher -like disease, Sci China Life Sciences, 2021, DOI: 10.1007/s11427-020 -1838-2
4. Wang Y, Zhou JB, QY Zeng, Wu SQ, Xue MQ, Fang PF, En-Duo Wang* and Zhou XL*. Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA^Lys, Sci China Life Sciences, 2020, 63, (8), 1227–1239.
5. Zhou JB, Wang Y, Zeng QY, Meng SX, En-Duo Wang* and Zhou XL*.  Molecular basis for t⁶A modification in human mitochondria, Nucleic Acids Research, 2020, 48 (6), 3181-3194.
6. Li J, Wang YN, Xu BS, Liu YP, Chen P, Zhou M, Long T, Li H, Dong H, Nie Y, En-Duo Wang*, Liu RJ*. Intellectual disability associated gene ftsj1 is responsible for 2'-O-methylation of nucleotides at the anticodon loop of specific tRNAs，2020，EMBO Reports，e50095. 
7. Liu RJ*, Long T, Li H, Zhao JH, Li J, Wang MZ, Palenica A, Lin JZ, Cusack S, and En-Duo Wang*. Structural basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond, Nucleic Acids Research, 2020, 48(9), 4946–4959
8. Zheng WQ, Zhang YY, Yao, Yuzhe Chen YZ, En-Duo Wang*, Chen C*and Zhou XL*. Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, Nucleic Acids Research, 2020, 48(12), 6799-6810
9. Jia-Yi Fan, Qian Huang, Quan-Quan Ji, En-Duo Wang*. LeuRS can leucylate type I and type II tRNA^Leus in Streptomyces coelicolor. Nucleic Acids Research, 2019, 47(12), 6369-6385
10. Jing Li, Hao Li, Tao Long, Han Dong, En-Duo Wang*, Liu RJ*. Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs, Nucleic Acids Research, 2019, 47(4), 2041-2055.
11. Qi-Yu Zeng, Gui-Xin Peng, Guang Li, Jin-Bo Zhou, Wen-Qiang Zheng, Mei-Qin Xue, En-Duo Wang*, Zhou XL*. The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, Nucleic Acids Research, 2019, 47(6), 3072-3085
12. Preyesh Stephen, Sheng Ye, Ming Zhou, Jian Song, Rong-Guang Zhang*, En-Duo Wang*, Richard Giegé and Sheng-Xiang Lin*. Structure of Escherichia coli arginyl-tRNA synthetase in complex with tRNA^Arg: pivotal role of the D-loop, J. Mol. Biol. 2018, 430, 1590-1605.
13. Yun Chen, Zhi-Rong Ruan, Yong Wang, Qian Huang, Mei-Qin Xue, Xiao-Long Zhou and En-Duo Wang* . A threonyl-tRNA synthetase-like protein has activities of tRNA aminoacylation and editing, Nucleic Acids Research, 2018, 46 (7), 3643-3656.
14. Yong Wang, Qi-Yu, Zeng, Wen-Qiang, Zheng, Quan-Quan Ji,Xiao-Long Zhou and En-Duo Wang*. A natural non-Watson-Crick base pair in human mitochondrial tRNA^Thr causes structural and functional susceptibility to local mutations, Nucleic Acids Research, 2018, 46(9), 4662-4676.
15. Taru Hilander, Xiao-Long Zhou, Svetlana Konovalova, Fu-Ping Zhang, Liliya Euro, Dmitri Chilov, Matti Poutanen, Joseph Chihade, En-Duo Wang* and Henna Tyynismaa*. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, Nucleic Acids Research, 2018, 46(2), 849-860.
16. Ru-Juan Liu, Tao Long, Jin Li, Hao Li, En-Duo Wang*. Structural basis for substrate binding and catalytic mechanism of a human RNA:m⁵C methyltransferase NSun6. Nucleic Acids Research, 2017,45(11), 6684-6697.
17. Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Cheng-Wu Chi and En-Duo Wang*. Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. Nucleic Acids Research, 2017, 45(12), 7367-7381.
18. Qing Ye, Quan-Quan Ji, Wei Yan, Fang Yang, En-Duo Wang*. Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. 2017, J. Biol. Chem., 292 (25), 10709-10722.
19. Tao Long, Jing Li, Hao Li,MiZhou, Xiao-Long Zhou, Ru-Juan Liu, En-Duo Wang*,Sequence-specific and shape-selective RNA recognition by the human RNA m5C methyltransferase NSun6. J. Biol. Chem.,2016, 291(46), 24293-24303.
20. Xiao-Long Zhou, YunChen, Zhi-Peng Fang, Zhi-Rong Ruan, Yong Wang, Ru-Juan Liu, Mei-QinXue,En-Duo Wang*,Translational quality control by bacterial threonyl-tRNA synthetases. J. Biol. Chem.,2016, 291 (40), 21208 –21221.
21. Yong Wang,Xiao-Long Zhou, Zhi-Rong Ruan, Ru-Juan Liu, Gilbert Eriani，En-Duo Wang*, A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural andfunctional defects. J. Biol. Chem., 2016, 291(12), 6507-6520.
22. Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Zhi-Rong Ruan,Xiao-Long Zhou, En-Duo Wang*, C-terminal domain of leucyl-tRNA synthetase from pathogenic Candida albicans recognizes both tRNASer and tRNALeu. J. Biol. Chem.,2016, 291 (7) , 3613-3625.
23. Ying Yang, Wei Liu , Zhi-Peng Fang , Juan Shi, Feng-Yu Che,Chun-Xia He, Li-Bo Yao, En-Duo Wang*, Yuan-Ming Wu* , A newly Identified missense mutation in FARS2 causes autosomal-Recessive Spastic Paraplegia.Human Mutation,2016, 37 (2),165-169.

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