2013年毕业于中科院生化细胞所获博士学位; 2015—2020年于加州大学圣地亚哥分校细胞与分子医学系从事博士后研究;2018—2020年获美国国立卫生研究院（NIH）K99项目资助；2020年9月起任中科院分子细胞科学卓越创新中心研究员、研究组长、博士生导师。

　　生殖细胞发育过程中，伴随着复杂的RNA调控(RNA regulation)与染色质重塑(chromatin remodeling)等生物学事件，个体遗传信息(genetic information)，以及环境、经历、疾病等形成的表观遗传信息(epigenetic information)被最终写入配子(卵母细胞与精子)。在早期胚胎发育中，新的生命个体读取父母本可遗传信息，开启下一轮生命周期。本研究组以RNA分子调控及染色质重塑调控为研究内容，探索其在哺乳动物生殖细胞发育、受精、及胚胎发育过程中的重要功能与机制，通过解析可遗传信息密码为人类疾病的预测、诊疗、以及辅助生殖提供新的靶点和理论依据。

1. Gou LT ^#, Lim DH ^#, Ma W ^#, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, and Fu XD. (2020). Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell 180, 1212-1227 e14.
2. Dai P ^#, Wang X ^#, Gou LT ^#, Li ZT ^#, Wen Z ^#, Chen ZG ^#, Hua MM, Zhong A, Wang L, Su H, Wan H, Qian K, Liao L, Li J, Tian B, Li D, Fu XD, Zhou Y, Liu MF. (2019). A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis. Cell 179, 1566-1581 e16.
3. Gou LT ^#, Kang JY ^#, Dai P ^#, Wang X ^#, Li F ^#, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ, and Liu MF. (2017). Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell 169, 1090-1104 e1013.
4. Li X, Zhou B, Chen L, Gou LT, Li H, and Fu XD. (2017). GRID-seq reveals the global RNA-chromatin interactome. Nat Biotechnol 35, 940-950.
5. Zhang P ^#, Kang JY ^#, Gou LT ^#, Wang J, Xue Y, Skogerboe G, Dai P, Huang DW, Chen R, Fu XD, Liu MF, and He S. (2015). MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res 25, 193-207.
6. Gou LT ^#, Dai P ^#, and Liu MF. (2014). Small noncoding RNAs and male infertility. Wiley Interdiscip Rev RNA 5, 733-745.
7. Gou LT ^#, Dai P ^#, Yang JH ^#, Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Wu LG, Shi HJ, Fu XD, Qu LH, Wang ED, and Liu MF. (2014). Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res 24, 680-700.
8. Zhao S ^#, Gou LT ^#, Zhang M ^#, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li J, Li D, Wang ED, and Liu MF. (2013). piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell 24, 13-25.

研究组照片