首页 全所PI名录
  • 王广川
  • E-mail: guangchuan.wang@sibcb.ac.cn
  • 实验室主页: 
    个人简介:
  • 2013年获浙江大学博士学位;2013—2016年担任浙江大学求是高等研究院讲师;2016—2021年在美国耶鲁大学医学院从事博士后研究, 获Rudolph J Anderson fellowship和CRI Irvington Postdoctoral fellowship资助; 2021年1月起担任中科院分子细胞科学卓越创新中心(生化与细胞所)研究员、研究组长、博士生导师。

    社会任职:
    研究方向:
  • 肿瘤免疫逃逸机制和免疫治疗
    研究工作:
  •   在肿瘤发展和转移过程中,肿瘤细胞通过基因突变塑造的微环境是其逃逸免疫监视和免疫治疗的关键。利用CRISPR基因编辑和高通量筛选技术剖析肿瘤微环境中,对于肿瘤免疫逃逸和免疫治疗应答具有关键调控作用的免疫细胞亚群和分子,旨在发现新的免疫治疗靶标。研究组还将进一步探索如何将上述免疫治疗靶标与T细胞疗法或溶瘤病毒疗法结合起来,开发新型免疫疗法。

    承担科研项目情况:
    代表论著:
    1. Wang G,*  Chow RD,* Zhu L,* Bai Z,* Ye L, Zhang F, Renauer PA, Dong MB, Dai X, Zhang X, Du Y, Cheng Y, Niu L, Chu Z, Kim K, Liao C, Clark P, Errami Y, and Chen S. CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade. Cancer Discovery 2020 Dec;10(12):1912-1933. (*equal contribution)
    2. Wang G,* Chow RD,* Bai Z, Zhu L, Errami Y, Dai X, Dong M, Ye L, Zhang X, Renauer PA, Park JJ, Shen L, Ye H, Fuchs CS, and Chen S. Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity. Nature Immunology 2019, 20: 1494–1505. (*equal contribution)
    3. Dong MB,* Wang G,* Chow RD,* Ye L,* Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen K, Renauer PA, Du Y, Shen J, Lam S, Zhou J, Lannin DR, Herbst RS, Chen S. Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells. Cell 2019, 178(5):1189-204. (*equal contribution)
    4. Chow RD,* Wang G,* Ye L,* Codina A, Kim HR, Shen L, Dong MB, Errami Y, Chen S. In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens. Nature Methods. 2019, 16(5):405-408. (*equal contribution)
    5. Codina A,* Renauer PA,* Wang G,* Chow RD,* Park JJ, Ye H, Zhang K, Dong MD, Gassaway B, Ye L, Errami Y, Shen L, Chang A, Jain D, Herbst RS, Bosenberg M, Rinehart J, Fan R, Chen S. Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo. Cell Systems. 2019, 8(2):136-151.e7. (*equal contribution)
    6. Wang G,* Chow RD,* Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, and Chen S. Mapping a Functional Cancer Genome Atlas of Tumor Suppressors in Mouse Liver Using AAV-CRISPR Mediated Direct in vivo Screening. Science Advances. 2018, 4: eaao5508. (*equal contribution)
    7. Chow RD,* Guzman CD,* Wang G,* Schmidt F,# Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience. 2017, 20(10):1329-1341. (*equal contribution)
    8. Wang G, Zhou H, Nian Q-G, Yang Y, Qin C-F, Tang R. Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine–silica. Chemical Science 2016, 7: 1753-1759.
    9. Wang G, Wang H-J, Zhou H, Nian Q-G, Song Z, Deng Y-Q, Wang X, Zhu S-Y, Li X-F, Qin C-F, Tang R. Hydrated silica exterior produced by biomimetic silicification confers viral vaccine heat-resistance. ACS Nano 2015, 9(1): 799-808.
    10. Wang G, Cao R-Y, Chen R, Mo L, Han J-F, Wang X, Xu X, Jiang T, Deng Y-Q, Lyu K, Zhu S-Y, Qin E-D, Tang R, Qin C-F. Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions. Proc Natl Acad Sci USA 2013, 110(19): 7619-7624.
    11. Wang G, Li X, Mo L, Song Z, Chen W, Deng Y, Zhao H, Qin E, Qin C, Tang R. Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration. Angew Chem Int Ed 2012, 51(42): 10576-10579.
    12. Wang G, Wang L, Liu P, Yan Y, Xu X, Tang R. Extracellular silica nanocoat confers thermotolerance on individual cells: a case study of material-based functionalization of living cells. ChemBioChem 2010, 11(17): 2368-2373.
    13. Zhou H,* Wang G,* Li XF, Li Y, Zhu SY, Qin CF, Tang R. Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity. Chem Commun 2016, 52(38):6447-50. (*equal contribution)
    14. Wang B,* Wang G,* Zhao B, Chen J, Zhang X, Tang R. Antigenic-sheltering universal red blood cells by polydopamine-based cell superficial-engineering. Chemical Science 2014, 5: 3463-3468. (*equal contribution)
    获奖及荣誉:
    研究组成员: