首页 全所PI名录
  • 曾安
  • 研究员,干细胞调控与组织器官再生
  • E-mail: azeng@sibcb.ac.cn
  • 实验室主页: www.sibcb.ac.cn/zenglab/
    个人简介:
  •   2013年毕业于中国科学院上海生命科学研究院,获博士学位;

      2013年底在美国Stowers/HHMI研究所从事博士后研究。

      2019年10月回国就任中国科学院生物化学与细胞生物学研究所研究员,研究组长。

    社会任职:
    研究方向:
  • 心脏修复与再生微环境调控
    研究工作:
  • 心肌梗死及相关心血管疾病导致的心肌细胞不可逆丧失,是限制心脏功能恢复的核心瓶颈。与部分低等物种相比,成年哺乳动物心脏再生能力极为有限,其关键障碍在于损伤后形成的复杂微环境更倾向于驱动炎症反应与纤维化,而非再生。因此,解析心脏损伤后微环境如何调控“再生与纤维化”命运决策,是当前再生医学与心血管生物学中的核心科学问题。

    我们的研究聚焦于心脏修复与再生的微环境调控机制,致力于系统解析损伤后多细胞协同网络如何决定组织修复结局。我们结合单细胞组学、空间转录组学和遗传干预策略,解析心肌细胞、免疫细胞、成纤维细胞及神经等关键细胞群之间的动态互作关系,重点关注炎症反应、代谢重编程及细胞间信号传导在再生过程中的整合作用。在此基础上,我们构建并应用多种人源干细胞衍生的心脏类器官与组装体模型,重建心脏损伤微环境及其细胞间互作过程,实现从机制解析到体外构建的跨越。这些模型不仅为解析人类心脏再生机制提供了可操作的平台,也为筛选调控再生微环境的关键分子与干预策略提供了重要工具。

    我们创新性利用不同生物系统中再生能力差异的本质机制,通过跨物种比较研究,提炼出调控再生潜能的保守原则,并将其转化应用于哺乳动物心脏修复。我们的长期目标是重塑损伤心脏的微环境状态,从而促进内源性心肌再生,抑制不良重构,为心肌梗死及心力衰竭等重大疾病提供新的治疗策略。

    承担科研项目情况:
    代表论著:
    1. Zhang TD, Fan L, Yao FB, Li G, Lin GT, Yang Y, Qian FL, Liu CC, Tang Q, Wang WD, Xu CF, Xu XL, Chang Y, Yang W, Gong JD, Wang YT, Huang SC, Guan RC, Lin L, Jing Q, Yang ZH, Pan TR, Cheng X, Lei Song L, Du MR*, Luo Z* & Zeng A* Cell Stem Cell, 2026, accepted. (Co-corresponding author, lead contact).
    2. Fan L, Tang Q, Wang YT, Sun H, Li G, Yang Y, Zhu HY, Liu ZY, Wang H, Wang H, Jing Q, Antos CL, Xiao H,Guan RC, Pei G, Ginhoux F, Zhou ZG*, & Zeng A*, Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages. Cell Stem Cell (2025), 2025 Dec 4;32(12):1849-1868 (Co-corresponding author, lead contact)
    3. Yan Y, Sun DQ, Hu J, Chen Y, Sun LD, Yu HS, Xiong YC, Huang ZD, Xia HR, Zhu XS, Bian DL, Sun FH, Hou LK, Wu CY, Fan OR, Hu HY, Zeng A*, Zhang LL, Sun YE, Wang CF, Zhang P. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer. Nat Genet (2024),
    4. Chen SY#, Zheng YJ#, Ran XJ#, Du H, Feng H, Yang L, Wen Y, Lin CD, Wang SH, Huang MW, Yan ZJ, Wu D, Wang HY, Ge GX, Zeng A*, Zeng YA*, Chen JF*. Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling. Cell Research, doi:10.1038/s41422-021-00561-2. (Co-corresponding author)
    5. Wang W, Hu CK, Zeng A, Alegre D, Hu DQ, Gotting K, Granillo AO, Wang YF, Robb S, Schnittker R, Zhang SS, Alegre D, Li H, Ross E, Zhang N, Brunet A, Sanchez Alvarado A. Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science, 2020; 369(6508), eaaz3093.
    6. Zeng A, Li H, Guo LH, Gao X, McKinney S, Wang YF, Yu ZL, Park J, Semerad C, Ross E, Cheng, LC, Davies, E, Lei, K, Wang W, Perera A, Hall K, Peak A, Box A, Sanchez Alvarado A. Prospectively isolated Tetraspanin+ neoblasts are adult pluripotent stem cells that underlie planaria regeneration. Cell, 2018;173(7):1593-1608.
    7. Zeng A, Li YQ, Wang C, Han XS, Li G, Wang JY, Li DS, Qin YW, Shi YF, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. Journal of Cell Biology, 2013;201(3):409-25.
    8. Wang C, Yang ZZ, Guo FH, Shi S, Han XS, Zeng A, Lin HF, Jing Q, Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. Journal of Biological Chemistry, (doi: 10.1074/jbc.RA118.004445), 2019.
    9. Li Y, Zeng A, Han XS, Li G, Li YQ, Shen B, Jing Q. Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea. Genomics Data, 2017 Dec; 14:114-125.
    10. Li Y, Zeng A, Li G, Guan YN, Yang, HT, Shen B. Jing Q. Dynamic regulation of small RNAome during the early stage of cardiac differentiation from pluripotent embryonic stem cells. Genomics Data, 2017 May; 12:136-145.
    11. Tian FJ, An LN, Wang GK, Zhu JQ, Li Q, Zhang YY, Zeng A, Zou J, Zhu RF, Han XS, Shen N, Yang HT, Zhao XX, Huang S, Qin YW, Jing Q. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovascular Research, 2014;103(1):100-110.
    12. Li YQ, Zeng A, Han XS, Wang C, Li G, Zhang ZC, Wang JY, Qin YW, Jing Q. Argonaute-2 regulates the proliferation of adult stem cells in planarian. Cell Research, 2011;21(12):1750-4.
    13. Qi MY, Wang ZZ, Zhang Z, Shao Q, Zeng A, Li XQ, Li WQ, Wang C, Tian FJ, Li Q, Zou J, Qin YW, Brewer G, Huang S, Jing Q. AU-Rich element-dependent translation repression requires the cooperation of Tristetraprolin and RCK/P54. Mol Cell Biol, 2012;32(5):913-28.
    14. Zhang ZC, Zeng A, Han XS, Li YQ, Jing Q. HDAC-1 determines adult stem cell maintenance in planarian. Journal of Shanghai Jiaotong University (Medical Science), 2013; 09-1202-07.
    获奖及荣誉:
    研究组成员: