2005年毕业于东北林业大学，获理学学士学位；2011年毕业于北京大学，获理学博士学位。2011年8月至2016年7月先后在美国约翰霍普金斯大学和纪念斯隆凯特琳癌症研究中心从事肿瘤生物学博士后研究；2016年8月受聘于中科院上海生化与细胞所，任研究员、研究组长、博士生导师。目前担任中国细胞生物学学会类器官研究与应用分会会长（2025年-今）、上海市细胞生物学学会副理事长（2025年-今）、中国遗传学会类器官分会副主任委员（2024年-今）、中国医药生物技术协会疾病模型专业委员会副主任委员（2021年-今）、Cell Reports期刊编委等学术任职。获得尚思探索学者（2024年）、国家杰出青年科学基金（2021年）、上海市优秀学术带头人（2021年）、国家高层次人才青年项目（2016年）等项目支持。曾获谈家桢生命科学创新奖（2025年）、中国科学院优秀导师（2025）、树兰医学青年奖（2024年）、上海市科技系统青年五四奖章（团体，负责人）（2021年）等荣誉。

我们以组织生理病理类器官模型、小鼠模型和临床肿瘤标本的整合分析为基础，运用类器官培养技术、单细胞多组学测序技术、空间多组学测序技术、细胞谱系示踪技术等分子细胞生物学技术手段，整合生物信息学分析方法，研究成体干细胞和肿瘤细胞命运可塑性的分子调控网络和治疗抵抗机理，筛选抗肿瘤新靶点，开发新型抗癌药物，合作开展相关临床试验，延长肿瘤患者的生存。目前的主要研究内容包括：

1)研究成体干细胞和肿瘤祖细胞，寻找维持成体干细胞多能性的主要调控基因，并基于此建立并优化类器官培养技术体系；

2)体外重建不同时期的肿瘤类器官模型，研究肿瘤细胞可塑性与肿瘤抗药性的分子机理；

3)建立来源于中国癌症病人的类器官模型库，进行高通量药物筛选，探寻新的抗肿瘤药物靶点，发展新型抗癌药物，合作开展相关临床试验。

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