2001年获武汉大学学士学位，2007年获中科院上海生科院健康科学研究所博士学位，2008至2013年在美国安德森癌症中心(MD Anderson Cancer Center)做博士后研究，并成为奥德赛学者(Odyssey Fellow)。2013年8月起担任中科院生物化学与细胞生物学研究所研究员，研究组长，博士生导师。

细胞代谢是维持生命活动的基础，而肿瘤的发生发展与代谢重塑紧密相关。为了适应自身基因突变和外部环境变化（如营养供给、免疫状态及饮食习惯等），肿瘤细胞会灵活调整代谢路径，以获取快速增殖所需的物质、能量，并维持内部氧化还原平衡。值得注意的是，某些基因突变还会导致代谢中间产物异常堆积，这些物质可进一步影响细胞内的信号传递与基因表达，从而促进肿瘤生长、转移，甚至导致治疗抵抗。本实验室聚焦于肿瘤代谢调控机制的研究，旨在探索代谢相关的生物标志物和潜在治疗靶点，为癌症的精准防治提供科学依据与新策略。

课题组聚焦以下三个研究方向：

1. 代谢物的信号调节功能
2. 肿瘤发生、转移及免疫逃逸的代谢调控机制
3. 肿瘤营养及靶向干预策略

（*Corresponding author）

1. Li Y, Zheng M, Zhu Z, Zhang Y, Ning P, Chen H, Gao R, Xu C, Wei X, Liu Y, Wang Y, Zhou R, Li Y, Li Z, Lv C, Liu C, Xu J, Guo Z, Hu Z, Fang L, Wei K, Feng M, Zhou C, She Y, Sun W, Chen E, Gustavo R. Plaza, He B, Jason Miska, Yang W*, Tang Y*, Liu H *, Chen C*, Cheng Y*. Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity. Cell Res. 2026 Feb 3. 
2. Zhang Y, Fei Q, Li Y, Wang S, Rong T, Wu X, Gao H, Chen C, Gao D, Zhao Y, Li G, Chu H*, Li W*, Yang W*. An alternative EGFR activation 1 by patient-derived R252C mutation promotes cancer progression. Nat Commun 2026 Jan 21.
3. Liu B, Liu M, Zhang Y, Zhu Y, Zhou D, Gao H, Yang F, Gao D, Zhao Y, Tao B*, Yao F*, Yang W*. Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis. Nat Commun. 2025 Dec 14;17(1):778.
4. Gao R, Xu C, Liu C, Zhu Z, Wang M, Wei X, Ning P, Zhang W, Li Y, Zhang Y, Shen J, Tong Y, Tao F, Chen X, Jiang X, Ren H, Lv C, Plaza GR, Miska J, Fan H, Zhang X, Tang Y, Dai Y*, Yang W*, He B*, Cheng Y*. An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano-Immunotherapy. Adv Mater. 2025 Sep 13:e04404.
5. Lin P, Qi Y, Chu H, Wu H, Zhang Y, Huang X, Li C, Xu X, Gao H, Zeng R, Li G*, Yang W*. PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate. Nat Commun. 2025 Jul 22;16(1):6736.  
6. Wang N, Lu S, Cao Z, Li H, Xu J, Zhou Q, Yin Hanrui, Qian Q, Zhang X, Tao M, Jiang Q, Zhou P, Zheng L, Liu H, Li H, Yin L, Gu Y, Dou X, Sun H, Wang W, Piao H, Li F, Xu Y, Yang W*, Chen S*, Liu J*. Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism. Cell Metab. 2025 Jun 3;37(6):1381-1399.e9.
7. Xing R, Liu R, Man Y, Liu C, Zhang Y, Gao H and Yang W*. MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury. Cell Discov. 2025 Feb 18;11(1):15.
8. Li F, Dai P, Shi H, Zhang Y, He J, Gopalan A, Li D, Chen Y, Du Y, Xu G, Yang W*, Liang C*, Gao D*. LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer. Cell Res. 2025 Jan;35(1):59-71.
9. Li Y, Tang S, Shi X, Lv J, Wu X, Zhang Y, Wang H, He J, Zhu Y, Ju Y, Zhang Y, Guo S, Yang W*, Yin H*, Chen L*, Gao D*, Gang Jin*. Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer. Cell Rep Med. 2023 Sep 19;4(9):101162.
10. Cai G, Qi Y, Wei P, Gao H, Xu C, Zhao Y, Qu X *, Yao F*, Yang W*. IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis. Adv Sci. 2023 Jun 9;e2206540.
11. Zhu W, Chu H, Zhang Y, Luo T, Yu H, Zhu H, Liu Y, Gao H, Zhao Y, Li Q*, Wang X*, Li G*, Yang W* Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis. Cell Res. 2023 Mar;33(3):245-257.
12. Zhang Y, Zhao M, Gao H, Yu G, Zhao Y*, Yao F*, Yang W*. MAPK signaling-induced Phosphorylation and Subcellular Translocation of PDHE1α Promotes Tumor Immune Evasion. Nat Metab. 2022 Mar;4(3):374-388.
13. Wu S, Cao R, Tao B, Wu P, Peng C, Gao H, Liang J*, Yang W*. Pyruvate facilitates FACT-mediated γH2AX loading to chromatin and promotes the radiation resistance of glioblastoma. Adv Sci. 2022 Jan 20;e2104055.
14. Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X*, Li X*, Li D* and Yang W*. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest, 2021 Nov 1;131(21):e146187:1-18.
15. Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G*, Yang W*. α-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor development. Mol Cell, 2019 Oct 3;76(1):148-162
16. Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G*, Yang W*. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature, 2019 Jul; 571(7763):127-131.
17. Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W*. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nat Commun, 2019 Mar 1; 10(1):991:1-13.
18. Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G*, Yang W*. Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking. PLOS Biol, Oct; 16(10): e2006483:1-27.
19. Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G*, Liang J, Yang W*. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Mol Cell, 2018 Jul 19;71(2):201-215
20. Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W and Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res, 2017 Mar; 27(3):329-351.
21. Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W*, Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun, 2016 Aug 3; 7:12431.