首页 全所PI名录
  • 王红艳
  • 研究员,研究组长,博士生导师
  • E-mail: hongyanwang@@sibcb.ac.cn
  • 实验室主页: 
    个人简介:
  • 安徽医科大学临床医学系本科和硕士;英国伦敦帝国理工学院博士;英国剑桥大学博士后。自2010年任中科院生化与细胞所研究员,研究组长,博士生导师。获中国科学院优秀指导老师称号等。

    社会任职:
    研究方向:
  • 免疫细胞调控炎症相关疾病的机制
    研究工作:
  • 免疫介导的炎症相关疾病与不适当或过度免疫反应造成的慢性和急性炎症反应密切相关。本课题组关注髓系细胞尤其巨噬细胞如何响应病灶微环境中的多种刺激因素,分泌趋化因子、生长因子、干扰素、促炎或者抑炎细胞因子,或者作为抗原呈递细胞调控T细胞活化增殖杀伤及耗竭等功能,进而影响损伤修复、病原感染、肿瘤、自身免疫性疾病等的发生发展。研究策略主要利用条件性敲除小鼠疾病模型,结合肿瘤等病人样品,联合单细胞测序和蛋白质组学以及代谢组学、生信分析等,筛选和鉴定能增强巨噬细胞和T细胞抵御炎症相关疾病的新策略。例如,首先筛查到病灶中紊乱表达的脂质胆固醇代谢物和代谢,然后阐明其调控髓系细胞或巨噬细胞向不同功能亚群分化、与肿瘤微环境中T细胞或其他细胞间的互作、炎症反应等机制。

    承担科研项目情况:
    代表论著:
    1. WY Li#, * M Jin#, HY Li#, RY Zhong#, ZH Lin#, M Shen#, HY Wang*. Amino acid and cholesterol metabolism in innate immunity. Molecular Cell, 85, October 16, 2025
    2. J Xiao#, S Wang#, M Jin#, B Wei* and HY Wang* Cholesterol metabolism regulates macrophage function and inflammation-related diseases. Trends in Cell Biology, 2025
    3. ZH Lin#, Y Zheng#, Y Zhong#, HY Wang*. Single-cell Insights into Macrophage Subtypes in Pulmonary Infections. Advanced Science. 2025, e10758
    4. J Xiao*, S Wang*, LL Chen*, XY Ding, MS Han, YX Zheng, MC Wang, D Yang, N Li, C Dong, H Shen, SF Wu, M Hu, C Su, WY Li, LJ Hui, YQ Ye#, HR Tang#, B Wei#, HY Wang#. 25-Hydroxycholesterol regulates lysosome AMPK activation and metabolic reprogramming to educate immunosuppressive macrophages, Immunity. 2024 May, 57:1-18
    5. X Zheng*, Q Jiang*, MS Han, FF Ye, MC Wang, Y Qiu, JL Wang, MX Gao, FJ Hou, and HY Wang#. FBXO38 regulates macrophage polarization to control the development of cancer and colitis, Cell Mol Immunol. 2023 Nov;20(11):1367-1378.
    6. X Zheng, J Xiao, Q Jiang, LM Zheng, C Liu, C Dong, YX Zheng, PL Ni, C Zhang, F Zhang, RY Zhong, HH Ding, Q Wang, Y Qiu, MX Gao, JP Ding, N Shen, B Wei#, HY Wang#. AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. EMBO J. 2022 Mar 15;41(6): e108016.
    7. L Ma*, WY Li*, YB Zhang*, LL Qi*, Q Zhao, N Li, Y Lu, LQ Zhang, F Zhou, YC Wu, YN He, HX Yu, YL He#, B Wei#, HY Wang#. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2022 Jun;18(6):1385-1400.
    8. XJ Li*, LL Qi*, D Yang, SJ Hao, F Zhang, XG Zhu, Y Sun, C Chen, J Ye, J Yang, L Zhao, D M Altmann, SB Cao, HY Wang#, B Wei#. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nat Neurosci. 2022 May;25(5):577-587.
    9. C Zhang*, WY Li *, XB Lei, ZF Xie, LL Qi, H Wang, X Xiao, J Xiao, YX Zheng, C Dong, X Zheng, SY Chen, JF Chen, B Sun, J Qin, QW Zhai, JS Li, B Wei#, JW Wang#, HY Wang#. Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity. Sci Adv. 2021 Sep 17;7(38): eabb5933.
    10. ZQ Li*, J Xiao*, XY Xu*, WY Li*, RY Zhong, LL Qi, JH Chen, GZ Cui, S Wang, YX Zheng, Y Qiu, S Li, X Zhou, Y Lu, JY Lyu, B Zhou, JW Zhou, NH Jing, B Wei#, J Hu#, HY Wang#. M-CSF, IL-6 and TGF-β promotes generation of a new subset of tissue repair macrophages for traumatic brain injury recovery. Sci Adv. 2021 Mar 12;7(11): eabb6260.
    11. C Liu, XY Xu, L Han, XP Wan, LM Zheng, CY Li, J Xiao, RY Zhong, X Zheng, Q Wang, HL Chen, B Wei#, H Wang#. LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumor and pathogens. PNAS 2020;117(32):19388-19398
    12. Y Lu*, Y Qiu*, P Chen, H Chang, L Guo, F Zhang, L Ma, C Zhang, X Zheng, J Xiao, R Zhong, L Han, X Xu, Y Zhang, D Li, G Zhong, R Boyton, Y Huang, Y He, R Hu#, B Wei#, H Wang# The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology, 2019,4:2331-46
    13. X Zhou, WY Li S Wang, P Zhang, Q Wang, J Xiao, C Zhang, X Zheng, X Xu, S Xue, L Hui, H Ji, B Wei#, H Wang#. YAP aggravates inflammatory bowel disease (IBD) via regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Reports, 2019, 27;1176-89
    14. XY Xu*, L Han*, G. Zhao, SJ Xue, Y Gao, J Xiao, ZY Wu, JP Ding, B Wei, RG Hu, H Wang. LRCH1 interferes with DOCK8-Cdc42 module-induced T cell migration and ameliorates multiple sclerosis. J Exp Med, 2017; 214(1):209-226.
    15. SJ Xue*, C Liu*, XJ Sun, WY Li, C Zhang, X Zhou, Y Lu, J Xiao, CY Li, XY Xu, B Sun, GL Xu, H Wang. TET3 inhibits IFN-I production independent of DNA demethylation. Cell Reports, 2016;16:1-10
    16. Zhang Y*, Lu Y*, Ma L, Jiao S, Chen J, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B#, Wang H# Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR-NF-kB signaling and protects from endotoxin shock. Immunity, 2014, 40: 501-514 (Cover Story)
    获奖及荣誉:
    研究组成员:
  • 合影