2016年6月毕业于中国科学技术大学获博士学位;2016年8月—2019年8月于Carnegie Institution for Science从事博士后研究;2019年8月—2021年5月于Duke University从事博士后研究。自2021年5月起任中国科学院分子细胞科学卓越创新中心(中科院生化细胞所)研究员、研究组长、博士生导师。

转座子（亦称为跳跃基因）是几乎所有真核生物基因组的重要组成成分；就人类而言，至少45%基因组是由转座子构成的。虽然生命体进化出了精细的调控网络去抑制转座子的活性，但是转座子的跳跃事件还是时有发生。由于转座子在转座过程中会引起DNA断裂而导致基因突变或者基因组不稳定，使其成为诱发疾病（如不育或者癌症）或者衰老的潜在驱动力。尽管科学家已经发现转座子激活与疾病发生之间的相关性，但是我们对转座子在基因组水平的跳跃调控机制、其潜在的功能以及如何导致疾病的仍然知之甚少。本实验室主要以果蝇和小鼠作为对象去研究转座子在基因组水平的转座行为、潜在功能和调控机制，并借此解密转座子对于发育和疾病的影响。本实验室主要聚焦以下研究方向：

研究方向#1：生命发育过程中转座子沉默的表观遗传调控机制；

研究方向#2：逆转座子挟持宿主实现其在基因组中扩增的分子机制；

研究方向#3：转座子协同和促进基因组进化的分子基础。

1. Deng Y^*, Liang Y^*, Luo YN, Ma L, Wu W, Wu W^# and Wang L^#. Hijacking pre-tRNA enables LTR-retrotransposon initiated constitutive heterochromatin formation. Science Advances (Accepted). (*Co-first authors, #co-corresponding authors)
2. Luo YN^*, Liang Y^*, Wu S, Deng Y, Wu W, Zhang Z, Wu W^#, Wang L^#. Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing mobile genetic elements. Molecular Cell 86, 2263-2280.e2210. 2026. (*Co-first authors, #co-corresponding authors)
3. Luo YN^*, Deng Y^*, Liang Y^*, Wu W, Wu W^#, Wang L^#. A de novo H3.2K9me2 deposition pathway establishes heterochromatin for suppressing transposon mobilization during fly somatic development. Nucleic Acids Res 54 (5): gkag146. 2026. (^*Co-first authors, ^#co-corresponding authors)
4. Luo YN, Liang Y, Wu W, Wang L. Evolutionarily conserved regulation and functions of H1 linker histones in development. Trends Genet 42, 362-375. 2026.
5. Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang D, Tan L, Xiang K, Wang Y, Alexander P, Li QJ, Yao TP, Zhang Z, Wang XF. Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype. Advanced Science 11 (2), 2303489. 2024.
6. Yang F, Su W, Chung OW, Tracy L, Wang L, Ramsden DA, Zhang Z. Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis. Nature 620 (7972), 218-225. 2023.
7. Wang L^*,#, Tracy L^*, Su W, Yang F, Feng Y, Silverman N and Zhang Z^#. Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses. Nature Genetics 54, 1933-1945. 2022. (^*Co-first authors, ^#co-corresponding authors)
8. Wang L^*, Dou K^*, Moon S, Tan F, Zhang Z. Hijacking oogenesis enables massive propagation of LINE and retroviral transposons. Cell. 174(5): 1082-1094. 2018. (^*Co-first authors)
9. Moon S, Cassani M, Lin Y, Wang L, Dou K, Zhang Z. A robust transposon-endogenizing response from germline stem cells. Developmental Cell. 47(5): 660-671. 2018.
10. Wang L, Xu F, Wang G, Wang X, Liang A, Huang H, Sun F. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Protein & Cell 7(10): 714-721. 2016.
11. Wang L, Guo Y, Liu W, Zhao W, Song G, Zhou T, Huang H, Guo X, Sun F. Proteomic analysis of pachytene spermatocytes in hybrid male sterility. Biology of Reproduction 95(3): 52. 2016.
12. Liu W, Wang L, Zhao W, Song G, Xu R, Wang G, Wang F, Li W, Lian J, Tian H, Wang X, Sun F. Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice. Developmental Biology 392(1): 108-116. 2014.
13. Wang L, Liu W, Zhao W, Song G, Wang G, Wang X, Sun F. Phosphorylation of CDK2 on threonine 160 influences silencing of sex chromosome during male meiosis. Biology of Reproduction 90(6): 138. 2014.