2009-2013年，复旦大学生命科学学院，生物科学学士

　　2013-2018年，新加坡国立大学医学院，免疫学博士

　　2018-2023年，斯坦福大学医学院，博士后

　　2023年6月起任中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)研究员，研究组长，博士生导师

　　T细胞受体结合配体peptide-MHC，是免疫系统识别多种多样抗原的分子基础。本课题组综合运用免疫学、蛋白质工程等方法，尤其是前期开创的T细胞展示文库技术和高通量功能筛选技术，致力于深入了解T细胞受体信号转导的分子机制，实现T细胞受体在细胞治疗中的应用。

　　本课题组聚焦以下研究方向：

　　1. 针对肿瘤抗原，改造高信号强度、生理亲和力、无脱靶毒性的T细胞受体，研究其在疾病模型中的免疫学机理与应用

　　2. 工程改造具有新表型的免疫受体-配体，鉴定新的免疫受体-配体

1. Xiang Zhao; Elizabeth M. Kolawole; Waipan Chan; Yinnian Feng; Xinbo Yang; Marvin H. Gee; Kevin M. Jude; Leah V. Sibener; Polly M. Fordyce; Ronald N. Germain; Brian D. Evavold; K. Christopher Garcia; Tuning T cell receptor sensitivity through catch bond engineering, Science, 2022, 376(6589)
2. Xiang Zhao; Shvetha Sankaran; Jiawei Yap; Chien Tei Too; Zi Zong Ho; Garry Dolton; Mateusz Legut; Ee Chee Ren; Andrew K.Sewell; Antonio Bertoletti; Paul A.MacAry; Joanna Brzostek; Nicholas R.J.Gascoigne; Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling, Nature Communications, 2018, 9(1): 2716
3. Xiang Zhao; Liang-Zhe Wu; Esther K. Y. Ng; Kerisa W. S. Leow; Qianru Wei; Nicholas R. J. Gascoigne; Joanna Brzostek; Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck, Frontiers in Immunology, 2021, 12
4. Xiang Zhao; Maryam Hamidinia; Joanna Ai Ling Choo; Chien Tei Too; Zi Zong Ho; Ee Chee Ren; Antonio Bertoletti; Paul A.MacAry; Keith G.Gould; Joanna Brzostek; Nicholas R.J.Gascoigne; Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation, Journal of Visualized Experiments, 2019, (144)
5. Yinnian Feng; Xiang Zhao; Adam K. White; K. Christopher Garcia; Polly M. Fordyce; A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation, Nature Methods, 2022, 19: 1295-1305
6. Xinbo Yang; Lee I. Garner; Ivan V. Zvyagin; Michael A. Paley; Ekaterina A. Komech; Kevin M. Jude; Xiang Zhao; Ricardo A. Fernandes; Lynn M. Hassman; Grace L. Paley; Christina S. Savvides; Simon Brackenridge; Max N. Quastel; Dmitriy M. Chudakov; Paul Bowness; Wayne M. Yokoyama; Andrew J. McMichael; Geraldine M. Gillespie; K. Christopher Garcia; Autoimmunity associated T cell receptors recognize HLA-B27-bound peptides, Nature, 2022, 612(7941): 771-777
7. Michelle Yen; Junming Ren; Qingxiang Liu; Caleb R. Glassman; Timothy P. Sheahan; Lora K. Picton; Fernando R. Moreira; Arjun Rustagi; Kevin M. Jude; Xiang Zhao; Catherine A. Blish; Ralph S. Baric; Leon L. Su; K. Christopher Garcia; Facile discovery of surrogate cytokine agonists, Cell, 2022, 185(8): 1414-1430.e19
8. Joanna Brzostek; Namrata Gautam; Xiang Zhao; Elijah W.Chen; Monika Mehta; Desmond W.H.Tung; Yen Leong Chua; Jiawei Yap; Su H.Cho; Shvetha Sankaran; Vasily Rybakin; Guo Fu; Nicholas R.J.Gascoigne; T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis, Nature Immunology, 2020, 21: 186-198
9. Yeteng Zhong; Zhuoran Ma; Feifei Wang; Xi Wang; Yijun Yang; Yulai Liu; Xiang Zhao; Jiachen Li; Haotian Du; Mingxi Zhang; Qiuhong Cui; Shoujun Zhu; Qinchao Sun; Hao Wan; Ye Tian; Qiang Liu; Weizhi Wang; K. Christopher Garcia; Hongjie Dai; In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles, Nature Biotechnology, 2019, 37(11): 1322-1331
10. Xinbo Yang; Daisuke Nishimiya; Sara L？chte; Kevin M. Jude; Marta Borowska; Christina S. Savvides; Michael Dougan; Leon Su; Xiang Zhao; Jacob Piehler; K. Christopher Garcia; Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy, Nature Biotechnology, 2023
11. Qianru Wei; Joanna Brzostek; Shvetha Sankaran; Javier Casas; Lois Shi-Qi Hew; Jiawei Yap; Xiang Zhao; Lukasz Wojciech; Nicholas R. J. Gascoigne; Lck bound to coreceptor is less active than free Lck, Proceedings of the National Academy of Sciences, 2020, 117(27): 15809- 15817
12. Liang‐zhe Wu; Renu Balyan; Joanna Brzostek; Xiang Zhao; Nicholas R J Gascoigne; Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response, EMBO reports, 2022, 24(1)