上海市分子男科学重点实验室

一、实验室简介 

上海市分子男科学重点实验室由我国首位在国际顶尖杂志《Science》上发表分子生物学领域研究成果的张永莲院士创办，实验室组建于2005年12月，并于2007年12月通过验收。实验室的依托单位为中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）。首届实验室主任张永莲院士、学术委员会主任陈德桂研究员；现任实验室主任童明汉研究员、学术委员会主任李劲松院士。

实验室定位：精子健康研究。研究方向：精子生物学的分子基础及应用研究。总体目标：揭示精子生命中的调控机理，形成一支在国际上有影响力的团队，为我国人口与健康重大需求提供源头创新成果。实验室经过二十余年的建设发展，已形成较为完善的研究体系和富有创新能力的攻关团队，在学科基础理论研究方面取得了具有国际影响力的科研成果。

实验室现有13位优秀学术带头人，其中院士1名、国家杰出青年科学基金项目获得者4名、国家科技创新领军人才2名、尚思探索学者3名。实验室成员先后荣获国家自然科学奖二等奖2项、中国生命科学十大进展2项、上海市自然科学一等奖6项、谈家桢生命科学创新奖5项。

二、实验室学术委员会

特邀学术顾问：  张永莲   院士

主任：  李劲松  院  士   中科院分子细胞科学卓越创新中心

委员：  于洪涛  教  授   西湖大学生命科学学院

史庆华  教  授   中国科技大学生命科学学院

闫  威  教  授   浙江大学国际医学院

李  林  院  士   中科院分子细胞科学卓越创新中心

张国捷  教  授   浙江大学医学院

沙家豪  教  授   南京医科大学基础医学院

周  琪  院  士   中科院动物研究所

陈德桂  研究员   中科院分子细胞科学卓越创新中心

赵世民  教  授   复旦大学生命科学学院

徐国良  院  士   中科院分子细胞科学卓越创新中心

童明汉  研究员   中科院分子细胞科学卓越创新中心

三、研究队伍 

四、发表论文 

2025

01.   Xinzhe Tang^#, Zetao Hu^#, Jian Ding, Meixia Wu, Pin Guan, Yawei Song, Yue Yin, Wei Wu, Jinbiao Ma, Ying Huang*, Ming-Han Tong*. (2025). In vitro reconstitution of meiotic DNA double-strand-break formation. Nature, 639(8055), 800–807.

02.   Yuanyong Huang^#, Yimei Sun^#, Hongyun Qi^#, Quanlong Jiang^#, Jialun Li, Mingzhi Chang, Xinyan Li, Lei Shu, Xiaoya Duan, Yiqin Wang, Kailun Fang, Hailei Mao, Mengmeng Han, Yuan Weng, Qiao Zhang, Zhaosu Chen, Wei Wei, Gaojie Song, Qiansen Zhang, Jiwen Li, Jing-Dong J Han, Charlie Degui Chen*, Jiemin Wong*. (2025). A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization. Nature, 647(8090), 786–797.

03.   Zhen Lin^# Bowen Rong^#, Ruitu Lyu^#*, Yuxuan Zheng, Yao Chen, Junyi Yan, Meixia Wu, Xiaogang Gao, Fuchou Tang*, Fei Lan*, Ming-Han Tong*. (2025). SETD1B-mediated broad H3K4me3 controls proper temporal patterns of gene expression critical for spermatid development. Cell research, 35(5), 345–361.

04.   Fei Li^#, Pengfei Dai^#, Huili Shi^#, Yajuan Zhang^#, Juan He, Anuradha Gopalan, Dan Li, Yu Chen, Yarui Du, Guoliang Xu, Weiwei Yang*, Chao Liang^*, Dong Gao*. (2025). LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer. Cell Res, 35(1), 59–71.

05.   Xiao-Peng Han^#, Ming Rao^#, Yu Chang^#, Jun-Yan Zhu, Jun Cheng, Yu-Ting Li, Wu Qiong, Si-Chao Ye, Qiurong Zhang, Shao-Qing Zhang, Ling-Ling Chen, Fajian Hou, Jin Zhong*, Jiaquan Liu*. (2025). ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly. Cell research, 35(11), 900–912.

06.   Yunguang Li^#, Shijie Tang^#, Huan Wang^#, Hongwen Zhu^#, Yurun Lu^#, Yehan Zhan^#, Shiwei Guo^#, Juan He, Yikai Li, Yi Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, Yi Ju, Yuejia Liu, Maoyuan Sun, Yong Wang*, Luonan Chen*, Hu Zhou*, Gang Jin*, Dong Gao*. (2025). A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy. Cell stem cell, 32(9), 1369–1389.e14.

07.   Duo Pan, Mo-Fang Liu*. (2025). tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress. Molecular cell, 85(4), 669–671.

08.   Meng Yan^#*, Xiaoyu Merlin Zhang^#, Zhenhua Yang, Miao Jia, Rongyu Liao, Jinsong Li*. (2025). Visualization of chromosomal reorganization induced by heterologous fusions in the mammalian nucleus. Nature communications, 16(1), 1485.

09.   Li Zhang^#, Jianshu Wang^#, Zhidong Tang^#, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue*, Yu Zhou*, Hong Cheng*. (2025). The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation. Nature communications, 16(1), 2605.

010. Pianpian Lin^#, Yijun Qi^#, Huiying Chu^#, Hongyu Wu, Yajuan Zhang, Xiaolan Huang, Chen Li, Xiaoyan Xu, Hong Gao, Rong Zeng, Guohui Li^*, Weiwei Yang*. (2025). PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate. Nature communications, 16(1), 6736.

011. Bing Liu^#, Min Liu^#, Yajuan Zhang, Yifei Zhu, Dingpei Zhou, Hong Gao, Fan Yang, Dong Gao, Yun Zhao, BangBao Tao*, Feng Yao*, Weiwei Yang*. (2025). Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis. Nature communications, 17(1):778.

012. Ru Xing^#, Ruilong Liu^#, Yongxiao Man^#, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang*. (2025). MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury. Cell discovery, 11(1), 15.

013. Yongjian Ma^#, Meng Yan^#, Zhenfei Xie, Hongling Zhang, Zhoujie Li, Yuanyuan Li, Suming Yang, Meiling Zhang, Wen Li^*, Jinsong Li*. (2025). Generation of live mice from haploid ESCs with germline-DMR deletions or switch. Cell discovery, 11(1), 5.

014. Zhiwen Liu^#, Xin Wan^#, Jiehui Chen^#, Yongjian Ma^#, Yonggao Fu^#, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang*, Dahai Zhu*, Jinsong Li*, Naihe Jing*, Xianfa Yang*. (2025). Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo. Cell discovery, 11(1), 53.

015. Jiaoyang Li^#, Zhizhou Xia^#, Bo Jiao^#, Zhitong Li, Donghe Li, Pengfei Xu, Yi Huang, Jiawei Nie, Yuqing Dan, Xu Huang, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Shiyu Ji, Mofang Liu*, Ping Liu*, Ruibao Ren*. (2025). Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice. Science advances, 11(42), eadv5189.

016. Shouhong Guang*, Mo-Fang Liu*. (2025). The discovery of tiny RNAs that have crucial roles. Science China. Life sciences, 68(4), 1183–1185.

017. Xidi Yin^#, Meng Yan^#, Yanbo Cheng, Zhoujie Li, Chong Cui, Yingyi Wang, Nan Liu, Yilai Shu, Jinsong Li*, Qing Li*^#. (2025). Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection. Science China. Life sciences, 68(5), 1524–1527.

018. Guang-Bo Jin^#, Shao-Qin Rong^#, Dong-Rui Yin, Zhou-Hao Deng, Xiao Ding, Meng-Yao Sheng, Hai Gao, Rahul M Kohli, Guo-Liang Xu*, Dan Zhou*. (2025). Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine. Proceedings of the National Academy of Sciences of the United States of America, 122(5), e2418318122.

019. Yi Zhu^#, Jianshu Wang^#, Deng Tong^#, Peixuan Jia^#, Suli Chen, Yangyang Li, Jiaying Fu, Qiming Li, Ping Hu, Yu Zhou & Hong Cheng*. (2026). 3'UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation. The EMBO journal, 45(3), 722–748.

020. Zetao Hu, Xinzhe Tang, Ming-Han Tong*, Ying Huang^*. (2025). In vitro reconstitution of SPO11-mediated DNA cleavage reveals mechanistic and clinical insights into meiotic DNA double-strand break formation. Clinical and translational medicine, 15(6), e70383.

021. Xiongfei Xu^#, Shiwei Guo^#, Haihui Gu^#, Zhanshan Cha^#, Xiaohan Shi, Xiaoyi Yin, Huan Wang, Suizhi Gao, Bo Li, Lingyu Zhu, Wei Jing, Kailian Zheng, Zhuo Shao, Peng Cheng, Chunhong Zheng, Yi-Ping Shih, Yunguang Li, Baohua Qian, Dong Gao*, Eric Tran^*, Gang Jin^*. (2025). Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients. JCI insight, 10(2), e181873.

022. Yanhao Yu^#, Chaochao Cen^#, Zhenyu Shao, Chaohan Wang, Yiqin Wang, Zongjie Miao, Meiling Sun, Chao Wang, Qing Xu, Kaiwei Liang, Jiaxin Zhou, Dan Zhou, Hongbin Ji, Guoliang Xu, Yarui Du*. (2025). APE1 promotes lung adenocarcinoma through G4-mediated transcriptional reprogramming of urea cycle metabolism. iScience, 28(5), 112275.

023. Zhen Lin#, Bowen Rong#, Meixia Wu, Junyi Yan, Tong Hong, Linjun Hou, Xinzhe Tang, Qiang Liu, Xiaozhong Peng, Yao Chen*, Fei La*, Ming-Han Tong*. (2025). The KMT2 complex protein ASH2L is required for meiotic prophase progression but dispensable for mitosis in differentiated spermatogonia. Development, 152(6), dev204630.

024. Ya-Nan Chang, Hong Cheng*. (2025). Safari in the RNA world: a special issue focused on RNA biogenesis, functions, and technologies. Acta biochimica et biophysica Sinica, 57(1), 1–2.

2024年 

01.   Fei Li^#, Xudong Xing^#, Qiqi Jin^#, Xiang-Ming Wang^#, Pengfei Dai^#, Ming Han^#, Huili Shi, Ze Zhang, Xianlong Shao, Yunyi Peng, Yiqin Zhu, Jiayi Xu, Dan Li, Yu Chen, Wei Wu, Qiao Wang, Chen Yu*, Luonan Chen*, Fan Bai*, Dong Gao*. (2024). Sex differences orchestrated by androgens at single-cell resolution. Nature, 629(8010), 193–200.

02.   Yanhong Li^#, Yifei Sang^#, Yunjian Chang^#, Chunfang Xu^#, Yikong Lin, Yao Zhang, Philip C N Chiu, William S B Yeung, Haisheng Zhou, Ningzheng Dong, Ling Xu, Jiajia Chen, Weijie Zhao, Lu Liu, Di Yu, Xingxing Zang, Jiangfeng Ye, Jinying Yang*, Qingyu Wu, Dajin Li*, Ligang Wu*, Meirong Du*. (2024). A Galectin-9-Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia. Circulation, 149(21), 1670–1688.

03.   Wangxin Guo^#, Xiaoyu Zhang^#, Lin Li^#, Pengfei Shao^#, Chao Liang^#, Hongjiong Zhang, Kuo Liu, Shuoming Wang, Yunyi Peng, Jun Luo, Yi Ju, Angelo M De Marzo, Chen Yu*, Luonan Chen*, Bin Zhou*, Dong Gao*. (2024). JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination. Nature genetics, 56(12), 2776–2789.

04.   Lei Lu^#, Meizhu Bai^#, Yufang Zheng, Xiukun Wang, Zhongzhong Chen, Rui Peng, Richard H Finnell, Tongjin Zhao, Chengtao Li, Bo Wu, Yunping Lei*, Jinsong Li*, Hongyan Wang*. (2024). The interaction of endorepellin and neurexin triggers neuroepithelial autophagy and maintains neural tube development. Science bulletin, 69(14), 2260–2272.

05.   Xin Wang*, Zhen-Yi Zhang, Shuang Zhao, Mo-Fang Liu*. (2024). New insights into small non-coding RNAs during spermatogenesis. Science bulletin, 69(11), 1581–1585.

06.   Keyun Wang^#, Li Zhang^#, Sirui Zhang^#, Ye Liu^#, Jiawei Mao^#, Zhen Liu^#, Lin Xu, Kejia Li, Jianshu Wang, Yanni Ma, Jiayi Wang, Haitao Li, Zefeng Wang*, Guohui Li*, Hong Cheng*, Mingliang Ye*. (2024). Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers. Nature communications, 15(1), 7459.

07.   Huan Wei^#, Jie Gao^#, Di-Hang Lin^#, Ruirong Geng^#, Jiaoyang Liao, Tian-Yu Huang, Guanyi Shang, Jiongjie Jing, Zong-Wei Fan, Duo Pan, Zi-Qi Yin, Tianming Li, Xinyu Liu, Shuang Zhao, Chen Chen, Jinsong Li, Xin Wang*, Deqiang Ding*, Mo-Fang Liu*. (2024). piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis. Nature communications, 15(1), 2343.

08.   Jing Fan^#*, Yimin Wang^#, Miaomiao Wen^#, Deng Tong^#, Kai Wu, Kunming Yan, Peixuan Jia, Yi Zhu, Qinyu Liu, Hecun Zou, Peng Zhao, Falong Lu, Caihong Yun, Yuanchao Xue, Yu Zhou*, Hong Cheng*. (2024). Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting. Molecular cell, 84(22), 4297–4313.e7.

09.   Xiao-Jie Zhang^#, Bin-Bin Han^#, Zhen-Yu Shao^#, Rui Yan^#, Juan Gao^#, Ting Liu, Zi-Yang Jin, Weiyi Lai, Zhi-Mei Xu, Chao-Han Wang, Fengjuan Zhang, Chan Gu, Yin Wang, Hailin Wang, Colum P Walsh, Fan Guo, Guo-Liang Xu*, Ya-Rui Du*. (2024). Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation. Nature structural & molecular biology, 31(1), 42–53.

010. Yanjing Zhu^#, Shijie Tang^#, Qiuyue Yuan^#, Jing Fu^#, Juan He^#, Zhuang Liu, Xiaofang Zhao, Yunguang Li, Yan Zhao, Yani Zhang, Xiaoyu Zhang, Yangqianwen Zhang, Yiqin Zhu, Wenwen Wang, Bo Zheng, Rui Wu, Tong Wu, Shuai Yang, Xinyao Qiu, Siyun Shen, Ji Hu, Luonan Chen*, Yong Wang*, Hongyang Wang*, Dong Gao*, Lei Chen*. (2024). Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions. Cell reports. Medicine, 5(2), 101375.

011. Qi Liu^#, Yajuan Zhang^#, Huimin Li^#, Hong Gao, Yijie Zhou, Dakui Luo, Zezhi Shan, Yufei Yang, Junyong Weng, Qingguo Li, Weiwei Yang*, Xinxiang Li*. (2024). Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB. Cell communication and signaling, 22(1), 278.

012. Lin Zhang^#, Shi-Meng Cao^#, Hao Wu, Meng Yan, Jinsong Li*, Ling-Ling Chen*. (2024). A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development. Science China. Life sciences, 67(11), 2297–2306.

013. Yanwei Zhang^#, Beibei Sun^#, Yinghong Y^#, Jun Lu^#, Yuqing Lou, Fangfei Qian, Tianxiang Chen, Li Zhang, Jiancheng Yang*, Hua Zhong*, Ligang Wu*, Baohui Han*. (2024). Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma. NPJ precision oncology, 8(1), 50.

014. Jia Xu^#, Siqi Liu^#, Yirui Ai^#, Yunbin Zhang, Shifeng Li*, Yiping Li*. (2024). Establishment and transcriptome analysis of single blastomere-derived cell lines from zebrafish. Journal of genetics and genomics, 51(9), 957–969.

015. Ke Wu, Fengxiao Bu, Yang Wu, Gen Zhang, Xin Wang, Shunmin He, Mo-Fang Liu*, Runsheng Chen*, Huijun Yuan*. (2024). Exploring noncoding variants in genetic diseases: from detection to functional insights. Journal of genetics and genomics, 51(2), 111–132.

016. Yuefang Liu, Zhen Lin, Junyi Yan, Xi Zhang, Ming-Han Tong*. (2024). Null Rad50 mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection, and complete loss of germ cells. Development, 151(8), dev202312.

017. Yuefang Liu, Zhen Lin, Junyi Yan, Xi Zhang, Ming-Han Tong*. (2024). A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells. Development, 151(8), dev202312.

018. Suli Chen, Qingyi Jiang, Jing Fan*, Hong Cheng*. (2024).Nuclear mRNA export. Acta biochimica et biophysica Sinica, 57(1), 84–100.

019. Junfei Wen, Qifan Zhu*, Yong Liu*, Lan-Tao Gou*. (2024). RNA modifications: emerging players in the regulation of reproduction and development. Acta biochimica et biophysica Sinica, 57(1), 33–58.

020. Haiyue Feng^#, Suming Yang^#, Lijun Zhang^#, Jingai Zhu, Jinsong Li*, Zhongzhou Yang*. (2024). A new Prdm1-Cre line is suitable for studying the second heart field development. Developmental biology, 514, 78–86.

021. Xiaoyu Zhang^#, Jian Wang^#, Wangxin Guo*, Hongjiong Zhang, Bin Zhou, Chen Yu, Dong Gao*. (2024). The cell fates of intermediate cell population in prostate development. Cell insight, 3(4), 100182.

022. Yao Chen*, Zhen Lin, Xi Zhang, Meixia Wu, Ming-Han Tong*. (2024). Isolation of Homogeneous Sub-populations of Spermatocytes from Mouse Testis. Methods in molecular biology, 2818, 115–132.

2023年 

01.   Lin Shan^#, Guang Xu^#, Run-Wen Yao, Peng-Fei Luan, Youkui Huang, Pei-Hong Zhang, Yu-Hang Pan, Lin Zhang, Xiang Gao, Ying Li, Shi-Meng Cao, Shuai-Xin Gao, Zheng-Hu Yang, Siqi Li, Liang-Zhong Yang, Ying Wang, Catharine C L Wong, Li Yu, Jinsong Li, Li Yang, Ling-Ling Chen*. (2023). Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature, 615(7952), 526–534.

02.   Chaofeng Tu^#, Junfei Wen^#, Weili Wang^#, Qifan Zhu^#, Ying Chen, Jianglu Cheng, Zeye Li, Lanlan Meng, Yong Li, Wenbin He, Chen Tan, Chunbo Xie, Shao-Mei Fu, Juan Du, Guangxiu Lu, Ge Lin*, Lan-Tao Gou*, Yue-Qiu Tan*. (2023). Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression. Cell discovery, 9(1), 87.

03.   Qing Li^#, Jiansen Lu^#, Xidi Yin^#, Yunjian Chang^#, Chao Wang^#, Meng Yan^#, Li Feng, Yanbo Cheng, Yun Gao, Beiying Xu, Yao Zhang, Yingyi Wang, Guizhong Cui, Luang Xu, Yidi Sun, Rong Zeng, Yixue Li, Naihe Jing, Guo-Liang Xu*, Ligang Wu*, Fuchou Tang*, Jinsong Li*. (2023). Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation. Nature communications, 14(1), 2922.

04.   Xiaolong Lv^#, Wen Xiao^#, Yana Lai^#, Zhaozhen Zhang^#, Hongdao Zhang^#, Chen Qiu, Li Hou, Qin Chen, Duanduan Wang, Yun Gao, Yuanyuan Song, Xinjia Shui, Qinghua Chen, Ruixin Qin, Shuang Liang, Wentao Zeng, Aimin Shi*, Jianmin Li*, Ligang Wu*. (2023). The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters. Nature communications, 14(1), 5267.

05.   Mingtong Ma^#, Yifang Dang^#, Boran Chang^#, Fei Wang, Junfang Xu, Li Chen, Hang Su, Jinsong Li*, Baoxue Ge*, Chang Chen*, Haipeng Liu*. (2023). TAK1 is an essential kinase for STING trafficking. Molecular cell, 83(21), 3885–3903.e5.

06.   Guoqing Cai^#, Yijun Qi^#, Ping Wei^#, Hong Gao, Chenqi Xu, Yun Zhao, Xiujuan Qu*, Feng Yao*, Weiwei Yang*. (2023). IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis. Advanced science, 10(21), e2206540.

07.   Yunguang Li^#, Shijie Tang^#, Xiaohan Shi^#, Jingwen Lv^#, Xueyuan Wu^#, Yehan Zhang^#, Huan Wang, Juan He, Yiqin Zhu, Yi Ju, Yajuan Zhang, Shiwei Guo, Weiwei Yang*, Huiyong Yin*, Luonan Chen*, Dong Gao*, Gang Jin*. (2023). Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer. Cell reports. Medicine, 4(9), 101162.

08.   Youkui Huang, Bao-Qing Gao, Quan Meng, Liang-Zhong Yang, Xu-Kai Ma, Hao Wu, Yu-Hang Pan, Li Yang, Dong Li, Ling-Ling Chen*. (2023). CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Genome biology, 24(1), 15.

09.    Xin Wang^#, Di-Hang Lin^#, Yue Yan^#, An-Hui Wang^#, Jiaoyang Liao^#, Qian Meng^#, Wen-Qing Yang#, Heng Zuo, Min-Min Hua, Fengjuan Zhang, Hongwen Zhu, Hu Zhou, Tian-Yu Huang, Rui He, Guangyong Li, Yue-Qiu Tan, Hui-Juan Shi, Lan-Tao Gou, Dangsheng Li, Ligang Wu, Yonggang Zheng, Xiang-Dong Fu, Jinsong Li, Rujuan Liu*, Guo-Hui Li*, Mo-Fang Liu*. (2023). The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility. Science China. Life sciences, 66(7), 1459–1481.

010. Ming-Na Zhao^#, Ling-Fei Zhang^#, Zhen Sun^#, Li-Hua Qiao^#, Tao Yang, Yi-Zhe Ren, Xian-Zhou Zhang, Lei Wu, Wen-Li Qian, Qiao-Mei Guo, Wan-Xing Xu, Xue-Qing Wang, Fei Wu, Lin Wang, Yutong Gu*, Mo-Fang Liu*, Jia-Tao Lou*. (2023). A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer. Cell death & disease, 14(5), 298.

011. Xu Zhou^#, Kailun Fang^#, Yanlei Liu, Weidong Li, Yingjin Tan, Jiaming Zhang, Xiaoxia Yu, Guoqiang Wang, Yanan Zhang, Yongliang Shang, Liangran Zhang*, Charlie Degui Chen*, Shunxin Wang*. (2023). ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression. Cell proliferation, 57(4), e13567.

012. Lan-Tao Gou*, Qifan Zhu, Mo-Fang Liu*. (2023). Small RNAs: An expanding world with therapeutic promises. Fundamental research, 3(5), 676–682.

013. Hong Chen^#, Ling-Fei Zhang^#, Lu Zhang, Ying Miao, Yun Xi, Mo-Fang Liu*, Min Zhang*, Biao Li*. (2023). CircANKRD17 promotes glycolysis by inhibiting miR-143 in breast cancer cells. Journal of cellular physiology, 238(12), 2765–2777.

014. Siqi Liu^#, Jia Xu^#, Yirui Ai^#, Yunbin Zhang, Shifeng Li*, Jinsong Li*, Yiping Li*. (2023). Derivation of zebrafish heart-related haploid cells. Journal of molecular cell biology, 15(12), mjad077.

015. Jiu-Ru Sun^#, Liang-Zhong Yang^#, Yang-Li Dai^#, Huang Wu, Siqi Li, Yi-Feng Xu, Youkui Huang, Hao Wu, Zheng Shen, Chaochun Zou*, Ling-Ling Chen*. (2023). Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis. RNA biology, 20(1), 419–430.

016. Yuhan Zhang^#, Jun-Yan Kang^#, Mofang Liu*, Ying Huang*. (2023). Diverse roles of biomolecular condensation in eukaryotic translational regulation. RNA biology, 20(1), 893–907.

017. Dong Gao*. (2023). Cell fate determination and lineage plasticity in prostate cancer. Asian journal of andrology, 25(2), 149–151.

018. Jun-Yan Kang^#, Ai Zhong^#, Ze Wen, Xinghai Yu, Yu Zhou, Mo-Fang Liu*. (2023). Polysome Profiling in Adult Mouse Testes. Bio-protocol, 13(11), e4686.

019. Yajuan Zhang^#*, Ming Zhao^#, Weiwei Yang*. (2023). Protocol to establish a mouse model for hepatic metastasis of colorectal cancer. STAR protocols, 4(1), 102023.

020. Yijun Qi^#, Guoqing Cai^#, Weiwei Yang*. (2023). Protocol for in situ visualization of mitochondrial ROS and apoptosis in spatially confined cells and sample preparation for biochemical analysis. STAR protocols, 5(1), 102802.

五、开放课题指南 

1.上海市分子男科学重点实验室开放课题指南 

2.上海市分子男科学重点实验室开放课题申请书 

六、实验室联系人 

电话：0086-21-54920084

传真：0086-21-54921016

联系人：许可

电子信箱：kexu@sibcb.ac.cn