代表性论文与综述--中国科学院分子细胞科学卓越创新中心

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Yufei Han,Qian Zhuang,Bo Sun,Wenping Lv,Sheng Wang,Qingjie Xiao,Bin Pang,Youli Zhou,Fuxing Wang,Pengliang Chi,Qisheng Wang,Zhen Li,Lizhe Zhu,Fuping Li,Dong Deng,Yingchih Chiang,Zhenfei Li,Ruobing Ren,Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism,Nat Commun2021 Jan 19.
Xinyuan Tong,Yueqing Chen,Xinsheng Zhu,Yi Ye,Yun Xue,Rui Wang,Yijun Gao,Wenjing Zhang,Weiqiang Gao,Lei Xiao,Haiquan Chen,Peng Zhang,Hongbin Ji,Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation,EMBO Mol Med2021 Jan 13.
Weifeng Guo,Shaowu Zhang,Yuehua Feng,Jing Liang,Tao Zeng,Luonan Chen,Network controllability-based algorithm to target personalized driver genes for discovering combinatorial drugs of individual patients,Nucleic Acids Res2021 Jan 12.
Chao Zhang,Yifan Wang,Yuanfei Zhu,Caixuan Liu,Chenjian Gu,Shiqi Xu,Yalei Wang,Yu Zhou,Yanxing Wang,Wenyu Han,Xiaoyu Hong,Yong Yang,Xueyang Zhang,Tingfeng Wang,Cong Xu,Qin Hong,Shutian Wang,Qiaoyu Zhao,Weihua Qiao,Jinkai Zang,Liangliang Kong,Fangfang Wang,Haikun Wang,Di Qu,Dimitri Lavillette,Hong Tang,Qiang Deng,Youhua Xie,Yao Cong,Zhong Huang,Development and structural basis of a two-Mab cocktail for treating SARS-CoV-2 infections,Nat Commun2021 Jan 11.
Luisa Statello, Chunjie Guo,Lingling Chen,Maite Huarte,Gene regulation by long non-coding RNAs and its biological functions,Nat Rev Mol Cell Biol2020 Dec 22.
Siqi Li,Xiang Li,Wei Xue,Lin Zhang,Shi-Meng Cao,Yunni Lei,LiangZhong Yang,Sikun Guo,Jialin Zhang,Xiang Gao,Jia Wei,Jinsong Li,LiYang,Lingling Chen,Screening for functional circular RNAs using the CRISPR-Cas13 system,Nat Methods2020 Dec 7.
Cong Xu,Yanxing Wang,Caixuan Liu,Chao Zhang,Wenyu Han,Xiaoyu Hong,Yifan Wang,Qin Hong,Shutian Wang,Qiaoyu Zhao,Yalei Wang,Yong Yang,Kaijian Chen,Wei Zheng,Liangliang Kong,Fangfang Wang,Qinyu Zuo,Zhong Huang,Yao Cong,Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM,Sci Adv2020 Dec 4.
Jiacheng Liu,Qianjin Li,Minghong He,Can Hu,Pengfei Dai,Feilong Meng,Bo O Zhou,Jinqiu Zhou,Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes,Nucleic Acids Res2020 Dec 3.
Shichao Duan,Hao Li,Yirong Zhang,Suming Yang,Yawen Chen,Benhua Qiu,Cheng Huang,Juan Wang,Jinsong Li,Xueliang Zhu,Xiumin Yan,Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling,EMBO J2020 Nov 26.
Alessandro Cicconi,Rekha Rai,Xuexue Xiong,Cayla Broton,Amer Al-Hiyasat,Chunyi Hu,Siying Dong,Wenqi Sun,Jennifer Garbarino,Ranjit S Bindra, Carl Schildkraut,Yong Chen,Sandy Chang,Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly,Nat Commun2020 Nov 17.
Jichang Han,Meng Yu,Yiqin Bai,Jianzhong Yu,Fei Jin,Chen Li,Rong Zeng,Jinghong Peng,Ao Li,Xiaomin Song,Hao Li,Dianqing Wu,Lin Li,Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors,Cancer Cell2020 Nov 12.
Heng Feng,Wenhui Xing,Yujiao Han,Jun Sun,Mingxiang Kong,Bo Gao,Yang Yang,Zi Yin,Xiao Chen,Yun Zhao,Qing Bi,Weiguo Zou,Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification,J Clin Invest2020 Aug 27.
Haixiao Wang,Huan Zhao,Huan Zhu,Yi Li,Juan Tang,Yan Li,Bin Zhou,Sca1+ cells minimally contribute to smooth muscle cells in Atherosclerosis,Circ Res2020 Nov 4.
Jun Sun,Heng Feng,Wenhui Xing,Yujiao Han,Jinlong Suo,Alisha R Yallowitz,Niandong Qian, Yujiang Shi,Matthew B Greenblatt,Weiguo Zou,Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing,Sci Adv2020 Nov 4.
Hui Hong,Shun Yao,Yuanyuan Zhang,Yi Ye,Cheng Li,Liang Hu,Yihua Sun,Hsinyi Huang,Hongbin Ji,In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor,PLoS Genet2020 Nov 2.
Jingzheng Li,Yafang Shang,Lin Wang,Bo Zhao,Chunli Sun,Jiali Li,Siling Liu,Cong Li,Min Tang,Feilong Meng,Ping Zheng,Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia,Sci Adv2020 Oct 28.
Jinlong Suo,Xue Feng,Jiayi Li,Jinghui Wang,Zuoyun Wang,Lei Zhang,Weiguo Zou,Zuoyun Wang,Lei Zhang,Weiguo Zou,VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription,Sci Adv2020 Oct 28.
Shenao Zhou,Wei Zhang,Gaihong Cai,Yingzhe Ding,Caixia Wei,Sheng Li,Yu Yang,Jie Qin,Dan Liu,Hao Zhang,Xiexiang Shao,Jianhua Wang,Hongye Wang,Wenjun Yang,Huating Wang,She Chen,Ping Hu,Liming Sun,Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration,Cell Res2020 Aug 24.
Guochao Chen,Duo Wang,Bin Wu,Fuxiang Yan,Hongjuan Xue,Quanmeng Wang,Shu Quan,Yong Chen,Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation,Nat Commun2020 Aug 21.
Wangxin Guo,Lin Li,Juan He,Zhuang Liu,Ming Han,Fei Li,Xinyi Xia,Xiaoyu Zhang,Yao Zhu,Yu Wei,Yunguang Li,Rebiguli Aji,Hao Dai,Hui Wei,Chunfeng Li,Yu Chen,Luonan Chen,Dong Gao,Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips,Nat Genet2020 Aug 17.

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