上海市分子男科学重点实验室

一、实验室简介 

上海市分子男科学重点实验室由我国首位在国际顶尖杂志《Science》上发表分子生物学领域研究成果的张永莲院士创办, 实验室组建于2005年12月,并于2007年12月通过验收。实验室的依托单位为中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)。首届实验室主任张永莲院士、学术委员会主任陈德桂研究员;现任实验室主任童明汉研究员。

实验室定位:精子健康研究。研究方向:精子生物学的分子基础及应用研究。总体目标:揭示精子生命中的调控机理,形成一支在国际上有影响力的团队,为我国人口与健康重大需求提供源头创新成果。实验室经过十多年的建设发展,已经形成比较完整的研究系统和集中攻关的创新团队,在学科基础理论研究方面取得了具有国际影响力的科研成果。

实验室现有14位优秀学术带头人,其中院士2名、国家杰出青年基金项目获得者6名、科技部重大科学研究计划项目负责人3名,以实验室PI为团队的基金委创新研究群体1个,国家科技创新领军人才3名。

二、实验室学术委员会 

特邀学术顾问:  张永莲    院 士

主任:  李劲松   院  士   中科院分子细胞科学卓越创新中心

委员:  李 林   院  士   中科院分子细胞科学卓越创新中心

徐国良   院 士   中科院分子细胞科学卓越创新中心

周 琪   院 士   中科院动物研究所

赵世民   教 授   复旦大学生命科学学院

张国捷   教 授   浙江大学医学院

沙家豪   教 授   南京医科大学基础医学院

史庆华   教 授   中国科技大学生命科学学院

于洪涛   教 授   西湖大学生命科学学院

闫 威   教 授   加州大学洛杉矶分校

童明汉   研究员   中科院分子细胞科学卓越创新中心

陈德桂   研究员   中科院分子细胞科学卓越创新中心

三、研究队伍

1. 精原干细胞命运决定和减数分裂启动研究

童明汉 研究员,博士生导师

2. 精子发生-精原干细胞维持和分化研究

陈德桂 研究员,博士生导师

3. 生殖细胞与胚胎发育

李逸平 研究员,博士生导师

4. 精原干细胞维持和分化的miRNA调控

吴立刚 研究员,博士生导师

5. PIWI/piRNA在精子形成中的功能机制

刘默芳 研究员,博士生导师

6. 细胞重编程与胚胎发育

李劲松 研究员,博士生导师,中科院院士

7. 雄性生殖细胞的表观遗传特性

徐国良 研究员,博士生导师,中科院院士

8. RNA结合蛋白在精子发生中的功能和机制研究

程 红 研究员,博士生导师

9. 长非编码RNA与干细胞

陈玲玲 研究员,博士生导师

10. 精原干细胞维持和分化的代谢重编程研究

杨巍维 研究员,博士生导师

11. 前列腺干细胞及其命运决定

高 栋 研究员,博士生导师

12. 生殖遗传过程中的RNA及染色质调控

苟兰涛 研究员,博士生导师

13. DNA损伤修复;RNA代谢;单分子荧光成像

刘珈泉 研究员,博士生导师

14. 基因表达调控与功能基因组学

柳  欣 研究员,博士生导师

四、发表论文

2022

  1. Yuqi Wang, Lingpu Zhang, Yan Liu, Linlin Tang, Juan He, Xiaqing Sun, Muhsin H. Younis, Daxiang Cui, Haihua Xiao, Dong Gao, Xiangyang Kong, Weibo Cai, Jie Song. Engineering CpG-ASO-Pt-loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy. Adv Healthc Mater. 2022 Jun 6.
  2. Wenwen Wang, Tinggan Yuan, Lili Ma, Yanjing Zhu, Jinxia Bao, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Shuai Yang, Xinyao Qiu, Siyun Shen, Rui Wu,Tong Wu, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen. Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors. Adv Sci. 2022 Jun 5.
  3. Li Yang, Jeremy E Wilusz, Lingling Chen. Biogenesis and Regulatory Roles of Circular RNAs. ANNU REV CELL DEV BI. 2022 May 24.
  4. Bin Chen, Yarui Du, Hong Zhu, Meiling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhimei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guoliang Xu, Hefeng Huang. Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. Nature. 2022 May 18.
  5. Chuxiao Liu, Lingling Chen. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022 May 17.
  6. Fei Wang, Mengmeng Zhao, Boran Chang, Yilong Zhou, Xiangyang Wu, Mingtong Ma, Siyu Liu, Yajuan Cao, Mengge Zheng, Yifang Dang, Junfang Xu, Li Chen, Tianhao Liu, Fen Tang, Yefei Ren, Zhu Xu, Zhiyong Mao, Kai Huang, Minhua Luo, Jingsong Li, Haipeng Liu, Baoxue Ge. Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Mol Cell. 2022 Apr 22.
  7. Xiaohan Shi, Yunguang Li, Qiuyue Yuan, Shijie Tang, Shiwei Guo, Yehan Zhang, Juan He, Xiaoyu Zhang, Ming Han, Zhuang Liu, Yiqin Zhu, Suizhi Gao, Huan Wang, Xiongfei Xu, Kailian Zheng, Wei Jing, Luonan Chen, Yong Wang, Gang Jin, Dong Gao. Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity. Nat Commun. 2022 Apr 21.
  8. Maozhou Zhao, Dihang Lin, Heng Zuo, Huan Wei, Xin Wang, Lantao Gou, Mofang Liu. piRNA 3' uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells. Cell Res. 2022 Apr 15.
  9. Xin Wang, Lantao Gou, Mofang Liu. Noncanonical Functions of PIWIL1/piRNAs in animal male germ cells and human diseases. Biol Reprod. 2022 Apr 9.
  10. Yajuan Zhang, Ming Zhao, Hong Gao, Guanzhen Yu, Yun Zhao, Feng Yao, Weiwei Yang. MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. Nat Metab. 2022 Mar 21.
  11. Jiangshan Cong, Yihong Yang, Xin Wang, Ying Shen, Huitao Qi, Chunyu Liu, Shuyan Tang, Sixian Wu, Shixiong Tian, Yiling Zhou, Xiaojin He, Lingbo Wang, Mofang Liu, Feng Zhang. Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis. Cell Discov. 2022 Mar 8.
  12. Siyang Wu,Ruixiu Cao,Bangbao Tao,Ping Wu,Chao Peng,Hong Gao,Ji Liang,Weiwei Yang. Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma. Adv Sci. 2022 Jan 20.
  13. Xiang Gao,Xukai Ma,Xiang Li,Guowei Li,Chuxiao Liu,Jun Zhang,Ying Wang,Jia Wei,Jia Chen,Lingling Chen,Li Yang. Knockout of circRNAs by base editing back-splice sites of circularized exons. Genome Biol. 2022 Jan 10.
  14. Haohao Zhang,Yiming Hu,Dandan Liu,Zhi Liu,Ningxia Xie,Sanhong Liu,Jie Zhang,Yuhang Jiang,Cuifeng Li,Qi Wang,Xi Chen,Deji Ye,Donglin Sun,Yujia Zhai,Xinhui Yan,Yongzhong Liu,Charlie Degui Chen,Xingxu Huang,Y. Eugene Chin,Yufang Shi,Baojin Wu,Xiaoren Zhang. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death Differ. 2022 Jan 9.

2021

  1. Chuxiao Liu,Sikun Guo,Fang Nan,Yifeng Xu,Li Yang,Lingling Chen. RNA circles with minimized immunogenicity as potent PKR inhibitors. Mol Cell. 2021 Dec 23.
  2. Qifan Zhu,Jane Allyn Kirby,Chen Chu,Lantao Gou. Small Noncoding RNAs in Reproduction and Infertility. Biomedicines. 2021 Dec 12.
  3. Hongling Zhang,Yuanyuan Li,Yongjian Ma,Chongping Lai,Qian Yu,Guangyong Shi,Jinsong Li. Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells. Protein Cell. 2021 Dec 5.
  4. Yunqing Gu,Jun Cao,Xinyu Zhang,Hai Gao,Yuyan Wang,Jia Wang,Juan He,Xiaoyi Jiang,Jinlan Zhang,Guanghui Shen,Jie Yang,Xichen Zheng,Gaowei Hu,Yuanfei Zhu,Shujuan Du,Yunkai Zhu,Rong Zhang,Jianqing Xu,Fei Lan,Di Qu,Guoliang Xu,Yun Zhao,Dong Gao,Youhua Xie,Min Luo,Zhigang Lu. Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res. 2021 Nov 26.
  5. Yajuan Zhang,Hua Yu,Jie Zhang,Hong Gao,Siyao Wang,Shuxian Li,Ping Wei,Ji Liang,Guanzhen Yu,Xiongjun Wang,Xinxiang Li,Dawei Li,Weiwei Yang. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest. 2021 Nov 1.
  6. Minghan Tong. Meiosis: no end in sight. Asian J Androl. 2021 Oct 22.
  7. Chuxiao Liu,Lingling Chen. Expanded regulation of circular RNA translation. Mol Cell. 2021 Oct 21.
  8. Junhao Fu,Qing Li,Xiaoyu Liu,Tianxiang Tu,Xiujuan Lv,Xidi Yin,Jineng Lv,Zongming Song,Jia Qu,Jinwei Zhang,Jinsong Li,Feng Gu. Human cell based directed evolution of adenine base editors with improved efficiency. Nat Commun. 2021 Oct 8.
  9. Yimin Wang,Jing Fan,Jianshu Wang,Yi Zhu,Lin Xu,Deng Tong,Hong Cheng. ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation. Nucleic Acids Res. 2021 Sep 16.
  10. Hongdao Zhang,Fengjuan Zhang,Qinghua Chen,Mingzhe Li,Xiaolong Lv,Yali Xiao,Zhaozhen Zhang,Li Hou,Yana Lai,Ying Zhang,Aihua Zhang,Shiqi Gao,Heling Fu,Wen Xiao,Jianli Zhou,Feiyang Diao,Aimin Shi,Youqiang Su,Wentao Zeng,Ligang Wu,Jianmin Li. The piRNA pathway is essential for generating functional oocytes in golden hamsters. Nat Cell Biol. 2021 Sep 6.
  11. Xiang Li,Jialin Zhang,Yunni Lei,Xiaoqi Liu,Wei Xue,Yang Zhang,Fan Nan,Xiang Gao,Jun Zhang,Jia Wei,Li Yang,Lingling Chen. Linking circular intronic RNA degradation and function in transcription by RNase H1. Sci China Life Sci. 2021 Aug 25.
  12. Yang Zhang,Li Yang,Lingling Chen. Characterization of Circular RNAs. Methods Mol Biol. 2021 Aug 21.
  13. Tianyuan Zhao,Qing Li,Chenchen Zhou,Xiujuan Lv,Hongyan Liu,Tianxiang Tu,Na Tang,Yanbo Cheng,Xiaoyu Liu,Changbao Liu,Junzhao Zhao,Zongming Song,Haoyi Wang,Jinsong Li,Feng Gu. Small-molecule compounds boost genome-editing efficiency of cytosine base editor. Nucleic Acids Res. 2021 Jul 30.
  14. Man Wu,Guang Xu,Chong Han,Pengfei Luan,Yuhang Xing,Fang Nan,Liangzhong Yang,Youkui Huang,Zhenghu Yang,Lin Shan,Li Yang,Jiaquan Liu,Lingling Chen. lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription. Science. 2021 Jul 30.
  15. Larry C Cheng,Dinghai Zheng,Qiang Zhang,Aysegul Guvenek, Hong Cheng,Bin Tian. Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum. Cell Rep. 2021 Jul 20.
  16. Xiwen Wang, Chuxiao Liu, Lingling Chen, Qiangfeng Cliff Zhang. RNA structure probing uncovers RNA structure-dependent biological functions. Nat Chem Boil. 2021 Jun 25.
  17. Shiraz Ahmed,Jiang Tao,Miaochen Wang,Yue Zhai,Wenhai Liu,Muthukumaran Jayachandran,Chen Chu,Shen Qu,Jin Zhang,Yonglian Zhang,Zhaoliang Fei. An improved lentiviral system for efficient expression and purification of β-defensins in mammalian cells. Biotechnol J. 2021 May 30.
  18. Guang Xu, Man Wu,Lingling Chen. LETN and NPM1 tango in human nucleoli. Cell Res. 2021 May 12.
  19. Shanhe Li,Ze Wen,Behafarid Ghalandari,Tianhao Zhou,Antony R. Warden,Ting Zhang,Peng Dai,Youyi Yu,Wenke Guo,Mofang Liu,Haiyang Xie,Xianting Ding. Single‐Cell Immunoblotting based on a Photoclick Hydrogel Enables High‐Throughput Screening and Accurate Profiling of Exogenous Gene Expression. Adv Mater. 2021 Apr 25.
  20. Yan Zhao,Zhixuan Li,Yanjing Zhu,Jing Fu,Xiaofang Zhao,Yani Zhang,Shan Wang,Jianmin Wu,Kaiting Wang,Rui Wu,Chengjun Sui,Siyun Shen,Xuan Wu,Hongyang Wang,Dong Gao,Lei Chen. Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids. Adv Sci. 2021 Mar 23.
  21. Fei Li,Ming Han,Pengfei Dai,Wei Xu,Juan He,Xiaoting Tao,Yang Wu,Xinyuan Tong,Xinyi Xia,Wangxin Guo,Yunjiao Zhou,Yunguang Li,Yiqin Zhu,Xiaoyu Zhang, Zhuang Liu,Rebiguli Aji,Xia Cai,Yutang Li,Di Qu,Yu Chen,Shibo Jiang,Qiao Wang,Hongbin Ji,Youhua Xie,Yihua Sun,Lu Lu,Dong Gao. Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nat Commun. 2021 Feb 8.
  22. Sikun Guo,Fang Nan,Chuxiao Liu,Li Yang,Lingling Chen. Mapping circular RNA structures in living cells by SHAPE-MaP. Methods. 2021 Feb 8.
  23. Yinghua Wang,Meng Yan,Xi Zhang,Xinyu Liu,Yifu Ding,Chongping Lai,Minghan Tong,Jinsong Li. Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells. Asian J Androl. 2021 Feb 2.
  24. Xiaoyuan Zhang,Yiping Li,Yunbin Zhang,Shifeng Li. Characterization of small RNAs in early zebrafish PGCs. Acta Biochim Biophys Sin. 2021 Jan 2.

2020

  1. Luisa Statello,Chunjie Guo,Lingling Chen,Maite Huarte. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2020 Dec 22.
  2. Siqi Li,Xiang Li,Wei Xue,Lin Zhang,Shi-Meng Cao,Yunni Lei,LiangZhong Yang,Sikun Guo,Jialin Zhang,Xiang Gao,Jia Wei,Jinsong Li,Li Yang,Lingling Chen. Screening for functional circular RNAs using the CRISPR-Cas13 system. Nat Methods. 2020 Dec 7.
  3. Leixin Wei,Peng Cao,Chen Xu,Huajian Zhong,Xiukun Wang,Meizhu Bai,Bo Hu,Ruizhe Wang,Ning Liu,Ye Tian,Huajiang Chen,Jinsong Li,Wen Yuan. Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling. FASEB J. 2020 Oct 22.
  4. Yao Zhang,Yilan Teng,Wangwen Xiao,Beiying Xu,Ya Zhao,Weihua Li,Ligang Wu. Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP. MOL THER-NUCL ACIDS. 2020 Oct 14.
  5. Meng Yan,Jinsong Li. Combined application of CRISPR-Cas and stem cells for clinical and basic research. Cell Regen. 2020 Oct 9.
  6. Jianshu Wang,Hong Cheng. Out or decay: fate determination of nuclear RNAs. Essays Biochem.  2020 Sep 4.
  7. Yang Wang,Lingling Chen. Organization and function of paraspeckles. Essays Biochem. 2020 Aug 24.
  8. Wangxin Guo,Lin Li,Juan He,Zhuang Liu,Ming Han,Fei Li,Xinyi Xia,Xiaoyu Zhang,Yao Zhu,Yu Wei,Yunguang Li,Rebiguli Aji,Hao Dai,Hui Wei,Chunfeng Li,Yu Chen,Luonan Chen,Dong Gao. Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips. Nat Genet. 2020 Aug 17.
  9. Chunjie Guo,Guang Xu,Lingling Chen. Mechanisms of Long Noncoding RNA Nuclear Retention. Trends Biochem Sci. 2020 Aug 13.
  10. Fei Li,Qiuyue Yuan,Wei Di,Xinyi Xia,Zhuang Liu,Ninghui Mao,Lin Li,Chunfeng Li,Juan He,Yunguang Li,Wangxin Guo,Xiaoyu Zhang,Yiqin Zhu,Rebiguli Aji,Shangqian Wang,Xinyuan Tong,Hongbin Ji,Ping Chi,Brett Carver,Yong Wang,Yu Chen,Dong Gao. ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. J Clin Invest. 2020 Jul 23.
  11. Yang Wang,Liangzhong Yang,Lingling Chen. Protocol for Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 System. STAR Protoc. 2020 Jun 3.
  12. Lantian Wang,Jing Fan,Lili Han,Haonan Qi,Yimin Wang,Hongye Wang,Suli Chen,Lei Du, Sheng Li,Yunbin Zhang,Wei Tang,Gaoxiang Ge,Weijun Pan,Ping Hu,Hong Cheng. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis. 2020 May 11.
  13. Lingling Chen. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 2020 May 4.
  14. Chen Chu,Lu Yu,Joelle Henry Berger,Yanfei Ru,Ayhan Kocer,Alexandre Champroux,Zhitong Li,Miao He,Shengsong Xie,Wubin Ma,Minjie Ni,Zimei Ni,Yunli Guo,Zhaoliang Fei,Lantao Gou,Qiang Liu,Samanta Sharma,Yu Zhou,Mofang Liu,Charlie Degui Chen,Andrew L Eamens,Brett Nixon,Yuchuan Zhou,Jo?l R Drevet,Yonglian Zhang. Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice. Asian J Androl. 2020 Apr 7.
  15. Chunjie Guo,Xukai Ma,Yuhang Xing,Chuanchuan Zheng,Yifeng Xu,Lin Shan,Jun Zhang,Shaohua Wang,Yangming Wang,Gordon G.Carmichael,Li Yang,Lingling Chen. Distinct processing of lncRNAs contributes to non-conserved functions in stem cells. Cell. 2020 Apr 6.
  16. Xiongwen Cao,Yanran Chen,Bin Wu,Xiaoyun Wang,Hongjuan Xue,Lu Yu,Jie Li,Yiqin Wang,Wei Wang,Qing Xu,Hailei Mao,Chao Peng,Gang Han,Charlie DeguiChen. Histone H4K20 Demethylation by Two hHR23 Proteins. Cell Rep. 2020 Mar 24.
  17. Feng Li,Peng Yuan,Ming Rao,Chunhui Jin,Wei Tang,Yefei Rong, Yunping Hu,Fengjuan Zhang,Tao Wei,Qi Yin,Tingbo Liang,Ligang Wu,Jinsong Li,Dangsheng Li,Yingbin Liu,Wenhui Lou,Shuang Zhao,Mofang Liu. piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis. Nat Cell Biol. 2020 Mar 16.
  18. Yu Jiang,Huiying Zhang,Zhen Lin,Yezhang Zhu,Chao Yu,Qianqian Sha,Minghan Tong,Li Shen,Hengyu Fan. CxxC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice. Development. 2020 Feb 24.
  19. Yao Chen,Ruitu Lyu,Bowen Rong,Yuxuan Zheng,Zhen Lin,Ruofei Dai,Xi Zhang,Nannan Xie,Siqing Wang,Fuchou Tang,Fei Lan,Minghan Tong. Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks. Cell Res. 2020 Feb 11.
  20. Runwen Yao,Chuxiao Liu, Lingling Chen. Linking RNA Processing and Function. Cold Spring Harb Symp Quant Biol. 2020 Feb 4.
  21. Peng Dai,Xin Wang,Mofang Liu. A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis. Sci China Life Sci. 2020 Jan 21.
  22. Xin Wang,Zhitong Li,Yue Yan,Penghui Lin,Wei Tang,Daniele Hasler,Rajyalakshmi Meduri,Ye Li,Minmin Hua,Huitao Qi,Dihang Lin,Huijuan Shi,Jingyi Hui,Jinsong Li,Dangsheng Li,Jianhua Yang,Jinzhong Lin,Gunter Meister,Utz Fischer,Mofang Liu. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity andSpermatogenesis in Mice. Mol Cell. 2020 Jan 20.

五、开放课题指南

1.上海市分子男科学重点实验室开放课题指南

2.上海市分子男科学重点实验室开放课题申请书

六、实验室联系人

电话:0086-21-54920084

传真:0086-21-54921016

联系人:王华青

电子信箱:wanghuaqing@sibcb.ac.cn